Seqens Seqens

X

Find Phosphoric Acid manufacturers, exporters & distributors on PharmaCompass

PharmaCompass
API SUPPLIERS
API Suppliers

API Suppliers

US DMFs Filed

US DMFs Filed

CEP/COS Certifications

CEP/COS Certifications

JDMFs Filed

JDMFs Filed

0

Other Certificates

Other Certificates

0

Other Suppliers

Other Suppliers

API REF. PRICE (USD / KG)
9
INTERMEDIATES

0

DOSSIERS // FDF
USA (Orange Book)

USA (Orange Book)

Europe

Europe

Canada

Canada

Australia

Australia

0

South Africa

South Africa

Uploaded Dossiers

Uploaded Dossiers

0

GLOBAL SALES (USD Million)

U.S. Medicaid

0

Annual Reports

0

EXCIPIENTS
PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

0

USFDA Exclusivities

0

DIGITAL CONTENT

Blog #PharmaFlow

0

News

0

REF STANDARD

EDQM

0

USP

JP

0

Other Listed Suppliers

SERVICES

0

04107_RIEDEL
Also known as: 7664-38-2, Orthophosphoric acid, O-phosphoric acid, Wc-reiniger, Acidum phosphoricum, Sonac
Molecular Formula
H3O4P
Molecular Weight
97.995  g/mol
InChI Key
NBIIXXVUZAFLBC-UHFFFAOYSA-N
FDA UNII
E4GA8884NN

Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++. Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed. In addition, phosphoric acid is a constituent in bone and teeth, and plays a role in many metabolic processes.
1 2D Structure

04107_RIEDEL

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
phosphoric acid
2.1.2 InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
2.1.3 InChI Key
NBIIXXVUZAFLBC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
E4GA8884NN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Concise Etchant

2. Condact

3. K-etchant

4. Orthophosphoric Acid

5. Uni-etch

2.3.2 Depositor-Supplied Synonyms

1. 7664-38-2

2. Orthophosphoric Acid

3. O-phosphoric Acid

4. Wc-reiniger

5. Acidum Phosphoricum

6. Sonac

7. Phosphorsaeure

8. Evits

9. Acide Phosphorique

10. Phosphoricum Acidum

11. Polyphosphoric Acid

12. Acido Fosforico

13. Phosphorsaeureloesungen

14. Fema No. 2900

15. Oleth-4 Phosphate

16. Superphosphoric Acid

17. Fosforzuuroplossingen

18. Ortho-phosphoric Acid

19. Vococid

20. Amberphos 54

21. Polyphosphoric Acids

22. Phosphate, Dihydrogen

23. Poly(phosphoric Acid)

24. Phosphoric Acid [nf]

25. Trihydroxidooxidophosphorus

26. Nsc-80804

27. H3po4

28. E4ga8884nn

29. Ins No.338

30. Chebi:26078

31. Ins-338

32. Mfcd00011340

33. 62046-92-8

34. Y-11a06

35. Phosphoric Acid (nf)

36. Ncgc00091005-01

37. E 338

38. E-338

39. Dsstox_cid_4263

40. Dsstox_rid_77346

41. Dsstox_gsid_24263

42. 9044-08-0

43. White Phosphoric Acid

44. Caswell No. 662

45. Phosphoric Acid 75%

46. Phosphoric Acid, Ortho-

47. Acido Fosforico [italian]

48. Acide Phosphorique [french]

49. Fosforzuuroplossingen [dutch]

50. Cas-7664-38-2

51. Ccris 2949

52. Phosphorsaeureloesungen [german]

53. Phosphoric Acid 85%

54. Hsdb 1187

55. Phosphoric Acid Solution

56. Phosphoric Acid, Acs Reagent, >=85 Wt. % In H2o

57. Einecs 231-633-2

58. Nsc 80804

59. Un1805

60. Epa Pesticide Chemical Code 076001

61. Unii-e4ga8884nn

62. Phospholeum

63. Phosphoric Cid

64. Ortho-phosphate

65. Phosphor-ic Acid

66. Polyphosphorc Acds

67. Nfb Orthophosphate

68. 2hp

69. Orthophosphate(3-)

70. Ortho Phosphoric Acid

71. Phosphate Ion(3-)

72. Tetraoxophosphoric Acid

73. Phosphate Anion(3-)

74. Phosphate (po43-)

75. Phosphoric Acid, 75%

76. Phosphoric Acid, 85%

77. Condensed Phosphoric Acid

78. Orthophosphate (po43-)

79. Phosphoric Acid Ion(3-)

80. Phosphate Ion (po43-)

81. Ec 231-633-2

82. Chembl1187

83. Phosphoric Acid, 10% V/v

84. Phosphoric Acid [ii]

85. Phosphoric Acid [mi]

86. Phosphoric Acid [fcc]

87. D-mannan, Dihydrogen Phosphate

88. Phosphoric Acid [fhfi]

89. Phosphoric Acid [hsdb]

90. Phosphoric Acid [inci]

91. Phosphoric Acid [vandf]

92. Dtxsid5024263

93. Phosphoric Acid [mart.]

94. Phosphoric Acid, Ar, >=88%

95. Phosphoric Acid, Technical Grade

96. [po(oh)3]

97. Bdbm14671

98. Chebi:52641

99. H3 P O4

100. Phosphoric Acid [usp-rs]

101. Phosphoric Acid [who-dd]

102. Trihydrogen Tetraoxophosphate(3-)

103. Phosphoric Acid Solution, 1.0 M

104. Phosphoric Acid, Ar, 88-93%

105. Phosphoric Acid, Lr, 88-93%

106. Phosphoric Acid (fragrance Grade)

107. Phosphoric Acid 85% Reagent Acs

108. Phosphoricum Acidum [hpus]

109. Nsc80804

110. Phosphoric Acid, 85%, Acs Grade

111. Phosphoric Acid, Puriss., >=99%

112. Phosphoric Acid, 85%, Hplc Grade

113. Tox21_111053

114. Tox21_202285

115. Tox21_303246

116. Phosphoric Acid, Acs Reagent, 85%

117. Phosphoric Acid [orange Book]

118. Phosphoric Acid, For Hplc, >=85%

119. Akos028109726

120. Db09394

121. Ncgc00091005-02

122. Ncgc00257071-01

123. Ncgc00259834-01

124. 68891-72-5

125. E338

126. Isooctanol, Reaction Products With Phosphorus Oxide (p2o5) And Polyethylene Glycol Monotridecyl Ether

127. Phosphoric Acid [un1805] [corrosive]

128. Phosphoric Acid, Bioultra, >=85% (t)

129. P1745

130. Phosphoric Acid, Saj First Grade, >=85.0%

131. C00009

132. D05467

133. Orthophosphoric Acid, 85% W/w Aqueous Solution

134. Phosphoric Acid, Jis Special Grade, >=85.0%

135. Q184782

136. Etidronate Disodium Impurity A [ep Impurity]

137. J-523994

138. Q27110336

139. Phosphoric Acid Solution, 85 Wt. % In H2o, Fcc, Fg

140. Phosphoric Acid, P.a., Acs Reagent, Reag. Iso, 85%

141. Phosphoric Acid, 85% In H2o, 99.99% Trace Metal Basis

142. Zoledronic Acid Monohydrate Impurity F [ep Impurity]

143. 730a9101-d5de-4668-97ca-7b6178b84417

144. Phosphoric Acid, Crystalline, >=99.999% Trace Metals Basis

145. Phosphoric Acid, Puriss. P.a., Crystallized, >=99.0% (t)

146. Pamidronate Disodium Pentahydrate Impurity B [ep Impurity]

147. Phosphoric Acid, 85 Wt. % In H2o, 99.99% Trace Metals Basis

148. Phosphoric Acid, Bioreagent, Suitable For Insect Cell Culture, 85%

149. Phosphoric Acid, United States Pharmacopeia (usp) Reference Standard

150. Phosphoric Acid, >=85 Wt. % In H2o, >=99.999% Trace Metals Basis

151. Phosphoric Acid, Semiconductor Grade Vlsi Puranal(tm) (honeywell 17644)

152. Phosphoric Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=85%

153. Phosphoric Acid, Semiconductor Grade Mos Puranal(tm) (honeywell 17938), >=85%

154. Phosphoric Acid, Semiconductor Grade Puranal(tm) (honeywell 17861), >=85%

155. Phosphate Atomic Spectroscopy Standard Concentrate 1.00 G Po43-, 1.00 G/l, For 1l Standard Solution, Analytical Standard

156. Phosphate Atomic Spectroscopy Standard Concentrate 10.00 G Po43-, 10.00 G/l, For 1 L Standard Solution, Analytical Standard

157. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

158. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 4.2 Mm X 8 In. , Wgs-5bl Coaxial Nmr Tube

159. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

160. Phosphoric Acid, Puriss. P.a., Acs Reagent, Packed In Coated, Shock- And Leak-protected Glass Bottle, >=85% (t)

161. Phosphoric Acid, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Nf, Fcc, 85.0-88.0%

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 97.995 g/mol
Molecular Formula H3O4P
XLogP3-2.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass97.97689557 g/mol
Monoisotopic Mass97.97689557 g/mol
Topological Polar Surface Area77.8 Ų
Heavy Atom Count5
Formal Charge0
Complexity49.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Diluted phosphoric acid national formulary: it has ... been employed in lead poisoning and in other conditions in which it is desired to administer large amount of phosphate and at /the/ same time produce mild acidosis. It has been given in dose of 60 mL daily (5 mL/hr) under carefully controlled conditions.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1263


Phosphoric acid is used ... to control the pH of the urinary tract in many animals, particularly in mink and cats, to prevent stone formation.

Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 17:108


Medication (Vet): Has been used to treat lead poisoning.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1266


4.2 Drug Warning

Acid cleaning: acids such as sulfuric ... phosphoric, sometimes with chromic or hydrofluoric, are used in water solutions and their splash hazard and corrosive action on skin, clothing, and machinery are well recognized. Bubbles of hydrogen rising from bath carry invisible acid mist. ...

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 2280


Splash contact of concentrated strong acids, such as ... phosphoric/acid/, ... can prove as, severely and devastatingly injurious to the eye as splashes of strong alkalies.

Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 46


4.3 Drug Indication

Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport.


5.2 MeSH Pharmacological Classification

Dental Materials

Materials used in the production of dental bases, restorations, impressions, prostheses, etc. (See all compounds classified as Dental Materials.)


5.3 Absorption, Distribution and Excretion

Absorption

Ortho phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract.


Route of Elimination

In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine.


Volume of Distribution

Absorbed phosphoric acid is distributed widely in the body as phosphate. Increased serum phosphate concentrations have been reported rarely after phosphoric acid ingestion


Clearance

Absorbed phosphate is filtered at the glomerulus and partially reabsorbed, with phosphate clearance 80 per cent of creatinine clearance.


The hygroscopic growth of phosphoric acid aerosol (diameter change > 0.5 micrometers) within the human tracheobronchial tree is modeled to investigate changes in deposition characteristics when compared to nonhygroscopic aerosols of identical preinspired size. Phosphoric acid particles are assumed to grow in a stepwise fashion to 99% relative humidity within conducting airways of the lung, having initially reached equilibrium at 90% relative humidity (T= 37 degrees) in the trachea. Deposition efficiencies for growth and no growth are calculated from theoretical equations for inertial impaction, sedimentation, and diffusion. The results show that neglecting the growth of an inhaled phosphoric acid aerosol may result in underestimation of the total deliverable dose by a factor of as much as 600-700%. Significant differences in regional deposition sites for hygroscopic or nonhygroscopic aerosols are predicted. Increased deposition efficiencies imply that measured physical properties (respirable fraction, aerodynamic diameter) of aerosols alone are not sufficient to assess deposition characteristics within the lung; hygroscopic growth must also be considered.

PMID:6884619 Martonen TB, Clark ML; Fundam Appl Toxicol 3 (1): 10-5 (1983)


/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1524


The level of inorganic phosphate in the blood is stabilized by exchange with the mineral deposit in the skeleton through the action of parathyroid hormone. This hormone inhibits tubular reabsorption of phosphates by the kidney and brings about demineralization of bone tissue through the action of osteoclasts. The amount of parathyroid hormone that enters the circulation is probably regulated by the calcium level of the blood.

WHO/FAO; Joint Expert Committee on Food Additives (JECFA): Phosphoric acid and phosphate salts (WHO Food Additives Series 17). Available from, as of July 28, 2011: https://www.inchem.org/pages/jecfa.html


5.4 Biological Half-Life

In infants with normal renal function the serum half-life of phosphate following single oral or rectal overdose is 5-11 hours


5.5 Mechanism of Action

Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.


Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.

WHO/FAO; Joint Expert Committee on Food Additives (JECFA): Phosphoric acid and phosphate salts (WHO Food Additives Series 17). Available from, as of July 28, 2011: https://www.inchem.org/pages/jecfa.html


Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty
Post Enquiry
POST ENQUIRY