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03C8I9296V

03C8I9296V

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Also known as: 88069-49-2, Pilsicainide hcl, N-(2,6-dimethylphenyl)-2-(hexahydro-1h-pyrrolizin-7a-yl)acetamide hydrochloride, Sunrythm, Pilsicainide (hydrochloride), Sun 1165

Molecular Formula

C₁₇H₂₅ClN₂O

Molecular Weight

308.8 g/mol

InChI Key

NZOSVDHCTCLGEB-UHFFFAOYSA-N

FDA UNII

03C8I9296V

1 2D Structure

03C8I9296V

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide;hydrochloride

2.1.2 InChI

InChI=1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H

2.1.3 InChI Key

NZOSVDHCTCLGEB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(=CC=C1)C)NC(=O)CC23CCCN2CCC3.Cl

2.2 Other Identifiers

2.2.1 UNII

03C8I9296V

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1h-pyrrolizine-7a(5h)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-, Hydrochloride (1:1)

2. 1h-pyrrolizine-7a(5h)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-, Hydrochloride Hemihydrate

3. N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide Hydrochloride

4. Pilsicainide

5. Pilsicainide Hydrochloride Hemihydrate

6. Pilsicainide Hydrochloride Hydrate

7. Sun 1165

8. Sun-1165

9. Tetrahydro-1h-pyrrolizine-7a(5h)-aceto-2',6'-xylidide

2.3.2 Depositor-Supplied Synonyms

1. 88069-49-2

2. Pilsicainide Hcl

3. N-(2,6-dimethylphenyl)-2-(hexahydro-1h-pyrrolizin-7a-yl)acetamide Hydrochloride

4. Sunrythm

5. Pilsicainide (hydrochloride)

6. Sun 1165

7. Pilsicainide Hydrochoride

8. Sun 1165; Sunrythm

9. 88069-49-2 (hcl)

10. 03c8i9296v

11. Sun-1165

12. N-(2,6-dimethylphenyl)-2-(tetrahydro-1h-pyrrolizin-7a(5h)-yl)acetamide Hydrochloride

13. N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide;hydrochloride

14. Unii-03c8i9296v

15. Pilsicainide Hydrochloride [jan]

16. N-(2,6-dimethylphenyl)-1h-pyrrolizine-8-acetamide Hydrochloride

17. N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide Monohydrochloride

18. 1h-pyrrolizine-8-acetamide, Hexahydro-n-(2,6-dimethylphenyl)-, Hydrochloride

19. N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide Hydrochloride

20. Schembl483632

21. Chembl4303511

22. Dtxsid7057860

23. Amy8863

24. Bcp09636

25. Mfcd00903769

26. Akos025287418

27. Ds-9555

28. Du-6552

29. 1h-pyrrolizine-7a(5h)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-, Monohydrochloride

30. Pilsicainide Hydrochloride [who-dd]

31. Hy-101245

32. Pilsicainide Hydrochloride, >=98% (hplc)

33. Cs-0021031

34. Ft-0630955

35. P2634

36. 69p492

37. A16362

38. C76901

39. A842458

40. Q27247552

41. 1h-pyrrolizine-7a(5h)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-, Hydrochloride (1:1)

42. N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide,hydrochloride

43. N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)ethanamide Hydrochloride

44. N-(2,6-dimethylphenyl)-2-(hexahydro-1h-pyrrolizin-7a-yl)acetamide Hcl

45. N-(2,6-dimethylphenyl)-2-(hexahydro-1h-pyrrolizin-7a-yl)acetamidehydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₅ClN₂O
Molecular Weight	308.8 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	308.1655411 g/mol
Monoisotopic Mass	308.1655411 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	348
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Sodium Channel Blockers

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. (See all compounds classified as Sodium Channel Blockers.)