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1. Iodine 127
2. Iodine-127
1. 7553-56-2
2. I
3. Molecular Iodine
4. Diiodine
5. Iodine Crystals
6. Iodine Solution
7. Iodine Sublimed
8. Tincture Iodine
9. Vistarin
10. Eranol
11. Iodio
12. Iode
13. Iosan Superdip
14. Jood
15. Iodine-127
16. Iodine Tincture
17. Iodine Colloidal
18. Iodine Tincture Usp
19. Ethanolic Solution Of Iodine
20. Iodine ((127)i2)
21. Jodosan
22. Tegodyne
23. Jod [german, Polish]
24. Iodum
25. I2
26. Iodine Strong
27. 12190-71-5
28. Mfcd00011355
29. Nsc-42355
30. Jod
31. Chebi:17606
32. Iodine, Crystalline
33. 9679tc07x4
34. Iodine Solution, Wijs
35. Actomar
36. Iodio [italian]
37. Jod (german, Polish)
38. Jood [dutch]
39. Iode [french]
40. Iodine [jan]
41. Caswell No. 501
42. Diiodane
43. Hsdb 34
44. Iodine (resublimed)
45. Ccris 9223
46. Iodine [usp:jan]
47. Einecs 231-442-4
48. Nsc 42355
49. Epa Pesticide Chemical Code 046905
50. Iodine-iodide
51. Iodonium Iodide
52. Diatomic Iodine
53. Iodine Mild
54. Ai3-08544
55. Iodine,
56. Unii-9679tc07x4
57. Iodine, Elemental
58. I2i
59. Cadex (tn)
60. Iodine, Acs Reagent
61. Iodine Solution, 1n
62. Iodine-molecule
63. Iodine Lump, Ultra Dry
64. Iodine Solution, 5 Mm
65. Iodine [vandf]
66. Iodine [hsdb]
67. Iodium [hpus]
68. Iodine (jp17/usp)
69. Iodine [who-dd]
70. Iodine [who-ip]
71. Iodine [ii]
72. Iodine [mi]
73. Iodine [mart.]
74. Iodine Solution, 0.5 M
75. Ec 231-442-4
76. Iodine, Resublimed Crystals
77. Dsstox_cid_14672
78. Dsstox_rid_79188
79. Iodine Mild [vandf]
80. Iodine Solution, 0.05 M
81. Dsstox_gsid_34672
82. Iodine [ep Impurity]
83. Iodine Solution, 5%, Lugol
84. Iodine [ep Monograph]
85. Iodine Strong [vandf]
86. Iodum [who-ip Latin]
87. Iodine [usp Monograph]
88. Iodine 0.1n Standard Solution
89. Chembl1201225
90. Dtxsid7034672
91. Iodine, 99.99% Metals Basis
92. Iodine, Ar, >=99.8%
93. Iodine, Lr, >=99.5%
94. Iodine , Lugol's Solution 5%
95. Amy39508
96. Bcp31677
97. Nsc42355
98. Iodine, 1.0n Standardized Solution
99. Tox21_301294
100. Mfcd00164163
101. Iodine Solution, 0.02n (n/50)
102. Iodine, 0.01n Standardized Solution
103. Akos015902439
104. Iodine Spheres, Ultra Dry, -10 Mesh
105. Db05382
106. Iodine, 99.999% Trace Metals Basis
107. Iodine, Saj First Grade, >=99.0%
108. Iodine, >=99.99% Trace Metals Basis
109. Iodine, Usp, 99.8-100.5%
110. Iodine, Jis Special Grade, >=99.8%
111. Iodine, Vetec(tm) Reagent Grade, 99%
112. Ncgc00257544-01
113. Bp-21210
114. Iodine, Acs Reagent, >=99.8%, Solid
115. Iodine, Reagentplus(r), >=99%, Chips
116. Cas-7553-56-2
117. Iodine, Purum P.a., >=99.5% (rt)
118. Diiodine;iodum; Jood; Iode; Jod; Lugol
119. Iodine, Resublimed Crystals, Puratronic(r)
120. Ft-0627248
121. Ft-0696506
122. I0604
123. C01382
124. D00108
125. Iodine, 1.0n Standardized Solution In Ethanol
126. Iodine, Reagentplus(r), >=99.8% (titration)
127. Q2064483
128. Iodine, Puriss., >=99.5% (rt), Particles (round)
129. Iodine Spheres, Ultra Dry, -10 Mesh, 99.998% Metals Basis
130. Iodine, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis
131. Iodine, Reagentplus(r), 99.7% Trace Metals Basis, Beads, 1-3 Mm
132. Iodide, Ion Chromatography Standard Solution, Specpure, I- 1000g/ml
133. Iodine, 0.1n Standardized Solution In Water, Contain 1-2% Potassium Iodide
134. Iodine Solution (0.02m In Thf/pyridine/h2o 70:20:10), For Dna Synthesis
135. Iodine Solution (0.05m In Thf/h2o/pyridine 70:20:10), For Dna Synthesis
136. Iodine, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.8-100.5%
| Molecular Weight | 253.8089 g/mol |
|---|---|
| Molecular Formula | I2 |
| XLogP3 | 1.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 253.80895 g/mol |
| Monoisotopic Mass | 253.80895 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 2 |
| Formal Charge | 0 |
| Complexity | 0 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Anti-Infective Agents, Local
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
In treatment of dendritic keratitis ... the corneas of patients have been ... exposed to air practically saturated with iodine vapor ... staining of corneal epithelium and ... loss of this layer, but complete recovery in two or three days. Tincture of iodine, swabbed on cornea, has been employed ... with same results.
Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 519
Chief use of solution of elemental iodine is in the disinfection of the skin. ... May also be employed in the treatment of wounds and abrasions. Applied to abraded tissue, aqueous solution are less irritating than the tincture. ... In treatment of cutaneous infections due to bacteria and fungi, usp tincture or solution ... may be employed.
Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 965
To treat thyrotoxic crisis or neonatal thyrotoxicosis.
American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 805
For more Therapeutic Uses (Complete) data for IODINE, ELEMENTAL (8 total), please visit the HSDB record page.
In rare instances, individual may exhibit hypersensitivity to iodine and react markedly to moderate amount of the element applied to the skin. ... Iodine has a relatively low toxicity when therapeutic preparations are ingested. Few patients succumb to the effects of the drug.
Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 965
POTENTIAL ADVERSE EFFECTS ON FETUS: Goiters, fetal encephalopathy. POTENTIAL SIDE EFFECTS ON BREAST-FED INFANT: May cause skin rash and thyroid suppression in infant. FDA Category:D (D = There is no evidence of human fetal risk but the potential benefits from use in pregnant women may be acceptable despite the potential risks (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective.) /Iodides/ /from table II/
Stockton, D.L. and A.S. Paller. J Am Acad Dermatol 23 (1):87-103 (1990)
Doses of 2-3 g have been fatal.
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1926
Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic).
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
Trace Elements
A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)
D - Dermatologicals
D08 - Antiseptics and disinfectants
D08A - Antiseptics and disinfectants
D08AG - Iodine products
D08AG03 - Iodine
Little information is available on the gastrointestinal absorption of forms of iodine other than iodide. Iodine compounds, such as I2 and iodates (e.g., NaIO3), may undergo reduction to iodide before being absorbed in the small intestine, and absorption may not be complete.
DHHS/ATSDR; Toxicological Profile for Iodine p. 132 (2004)
Orally administered iodine is rapidly excreted in the urine and in smaller quantities in saliva, milk, sweat, bile, and other secretions. The storage of iodine in the thyroid depends upon the functional state of the gland.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2974
Iodine is absorbed from the lung, converted to iodide in the body, and then excreted, mainly in urine.
International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1154
Iodine is removed from the blood & incorporated into the organic form in the thyroid gland. Free iodine is negligible in the body.
Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 802
For more Absorption, Distribution and Excretion (Complete) data for IODINE, ELEMENTAL (8 total), please visit the HSDB record page.
Food present in the digestive tract rapidly inactivates iodine by converting it to comparatively harmless iodide.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-213
Inhaled methyl iodide and molecular iodine (I2) are rapidly converted to iodide. /Methyl iodide and iodine/
DHHS/ATSDR; Toxicological Profile for Iodine p. 141 (2004)
Ingested molecular iodine (I2) is converted to iodide.
DHHS/ATSDR; Toxicological Profile for Iodine p. 132 (2004)
Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-nitrosourea-induced mammary carcinogenesis, to regress 7,12-dimethylbenz(a)anthracene-induced breast tumors in rats.It has also been shown to have beneficial effects in fibrocystic human breast disease.
An acute iodide excess (above the preexisting dietary intake) transiently decreases the production of thyroid hormones in the thyroid gland; this is referred to as the acute Wolff-Chaikoff effect. In normal people, this is followed by a return to normal levels of hormone synthesis, referred to as escape from the acute Wolff-Chaikoff effect, without a significant change in circulating hormone levels. Escape is thought to be the result of down regulation of the sodium-iodide symport (NIS), the iodide transporter in the thyroid gland, resulting in a decrease in the intrathyroidal iodine and the resumption of normal hormone synthesis. An acute or chronic excess of iodide can also decrease circulating T4 and T3 levels and induce a hypothyroid state in some people who have underlying thyroid disorders. These effects are the result of a failure to escape from the acute Wolff-Chaikoff effect. Most people who experience iodine-induced hypothyroidism recover when the excess iodine intake is discontinued.
DHHS/ATSDR; Toxicological Profile for Iodine p. 51 (2004)
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