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1 | Egl nine homolog 3","graph1":"Undisclosed","graph2":"Phase I","graph3":"Akebia Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Akebia Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Akebia Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Akebia Therapeutics","sponsor":"Hermann-Texas Medical Center","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Vadadustat","moa":"Egl nine homolog 1 | Hypoxia-inducible factor prolyl hydroxylase 1 | Egl nine homolog 3","graph1":"Infections and Infectious Diseases","graph2":"IND Enabling","graph3":"Akebia Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Akebia Therapeutics \/ Hermann-Texas Medical Center","highestDevelopmentStatusID":"5","companyTruncated":"Akebia Therapeutics \/ Hermann-Texas Medical Center"},{"orgOrder":0,"company":"Akebia Therapeutics","sponsor":"US Renal Care","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Agreement","leadProduct":"Vadadustat","moa":"Egl nine homolog 1 | Hypoxia-inducible factor prolyl hydroxylase 1 | Egl nine homolog 3","graph1":"Nephrology","graph2":"Approved FDF","graph3":"Akebia Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Akebia Therapeutics \/ US Renal Care","highestDevelopmentStatusID":"15","companyTruncated":"Akebia Therapeutics \/ US Renal Care"},{"orgOrder":0,"company":"University of Texas Health Science Center at Houston","sponsor":"Akebia Therapeutics | US Department of Defense","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Vadadustat","moa":"Egl nine homolog 1 | Hypoxia-inducible factor prolyl hydroxylase 1 | Egl nine homolog 3","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"University of Texas Health Science Center at Houston","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University of Texas Health Science Center at Houston \/ Akebia Therapeutics | US Department of Defense","highestDevelopmentStatusID":"8","companyTruncated":"University of Texas Health Science Center at Houston \/ Akebia Therapeutics | US Department of Defense"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 30, 2025

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The proceeds from the offering will be used for R&D and commercialization of Vafseo (vadadustat) which is approved for the treatment of anemia due to chronic kidney disease in adults.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 19, 2025

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : Leerink Partners

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The proceeds from the offering will be used for R&D and commercialization of Vafseo (vadadustat) which is approved for the treatment of anemia due to chronic kidney disease in adults.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 19, 2025

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : Leerink Partners

                          Deal Size : $50.0 million

                          Deal Type : Public Offering

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the agreement, Er-Kim partner with the MEDICE to commercialize the Vafseo (vadadustat). It is being indicated for the treatment of of symptomatic anaemia associated with CKD in adults.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 14, 2025

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : MEDICE Health Family

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Vafseo (vadadustat) is a once-daily oral hypoxia-inducible factor prolyl hydroxylase inhibitor. It is approved for the treatment of anemia due to chronic kidney disease in adult patients on dialysis.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 03, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Vafseo (vadadustat) is a once-daily oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. It is approved for anemia due to chronic kidney disease in adult patients on dialysis.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 07, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          USRC Kidney Research

                          Country arrow
                          ChemOutsourcing
                          Not Confirmed

                          USRC Kidney Research

                          Country arrow
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 25, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase III

                          Sponsor : Akebia Therapeutics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The agreement aims to enable access to Vafseo (vadadustat), a once-daily oral hypoxia-inducible factor prolyl hydroxylase inhibitor, for patients on dialysis.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 10, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : US Renal Care

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Vafseo (vadadustat) is a once-daily oral hypoxia-inducible factor prolyl hydroxylase inhibitor. It is approved for the treatment of anemia due to chronic kidney disease in adult patients on dialysis.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 09, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : US Renal Care

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Vafseo (vadadustat) is a once-daily oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. It is approved for anemia due to chronic kidney disease in adult patients on dialysis.

                          Product Name : Vafseo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 27, 2024

                          Lead Product(s) : Vadadustat

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : CSL Vifor

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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