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Find Clinical Drug Pipeline Developments & Deals for Encoberminogene Rezmadenovec

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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The financing will support the company in advancing the clinical development of XC001 (encoberminogene rezmadenovec) for the treating Refractory Angina.

                          Product Name : XC001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 07, 2025

                          Lead Product(s) : Encoberminogene Rezmadenovec

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Jeito Capital

                          Deal Size : $67.5 million

                          Deal Type : Series B Financing

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The collaboration aims to evaluate Exelixis’ TKI XL092 (zanzalintinib) with Merck’s Keytruda (pembrolizumab) for HNSCC, and with Welireg (belzutifan), an oral HIF-2 alpha inhibitor, for RCC.

                          Product Name : XL092

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 14, 2024

                          Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Merck & Co

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The proceeds will be used to rapidly advance AB521 (casdatifan), its potential best-in-class HIF-2a inhibitor, for the treatment of renal cell cancer.

                          Product Name : AB521

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 27, 2024

                          Lead Product(s) : Casdatifan,Encoberminogene Rezmadenovec

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Hercules Capital

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XC001 (encoberminogene rezmadenovec) is designed to promote new blood vessels in the heart that will bypass diseased blood vessels and improve blood flow in patients with refractory angina.

                          Product Name : XC001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          July 18, 2023

                          Lead Product(s) : Encoberminogene Rezmadenovec

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.

                          Product Name : XL092

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          April 12, 2023

                          Lead Product(s) : Encoberminogene Rezmadenovec,Casdatifan

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Arcus Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XL092 (Zanzalintinib) is a Vegf/metaxl/mer Inhibitor small molecule drug candidate, which is currently being evaluated in combination with "Pembrolizumab" for the treatment of PD-L1-positive recurrent or metastatic squamous cell carcinoma of the head and...

                          Product Name : XL092

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 12, 2023

                          Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XC001 is designed to promote new blood vessels in the heart that will bypass diseased blood vessels and improve blood flow. By restoring blood flow, it may decrease chest pain associated with refractory angina.

                          Product Name : XC001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          January 26, 2023

                          Lead Product(s) : Encoberminogene Rezmadenovec

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Zanzalintinib, which was adopted as the generic name for XL092, is a next-generation tyrosine kinase inhibitor (TKI) in development for multiple advanced tumor types. Zanzalintinib is currently being developed for the treatment of advanced solid tumors.

                          Product Name : XL092

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 22, 2022

                          Lead Product(s) : Encoberminogene Rezmadenovec,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XL092 demonstrated preliminary clinical activity similar to that observed with cabozantinib in phase 1 across a range of solid tumors and dose levels, with a manageable safety profile.

                          Product Name : XL092

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 09, 2022

                          Lead Product(s) : Encoberminogene Rezmadenovec,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XC001 (encoberminogene rezmadenovec) is a locally administered, single-dose gene therapy currently in development as a novel approach to treating patients with refractory angina who have no other medical and surgical options.

                          Product Name : XC001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 28, 2022

                          Lead Product(s) : Encoberminogene Rezmadenovec

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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