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    [{"orgOrder":0,"company":"XyloCor Therapeutics","sponsor":"Fountain Healthcare Partners","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Series A Financing","leadProduct":"Encoberminogene Rezmadenovec","moa":"VEGF gene producer","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I\/ Phase II","graph3":"XyloCor Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intramyocardial Injection","sponsorNew":"XyloCor Therapeutics \/ Fountain Healthcare Partners","highestDevelopmentStatusID":"7","companyTruncated":"XyloCor Therapeutics \/ Fountain Healthcare Partners"},{"orgOrder":0,"company":"XyloCor Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene 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Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Collaboration","leadProduct":"Encoberminogene Rezmadenovec","moa":"||GRP78 upregulation pathway","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Merck & Co","highestDevelopmentStatusID":"9","companyTruncated":"Exelixis \/ Merck & Co"},{"orgOrder":0,"company":"XyloCor Therapeutics","sponsor":"Jeito Capital","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Series B Financing","leadProduct":"Encoberminogene Rezmadenovec","moa":"GRP78 upregulation pathway","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I\/ Phase II","graph3":"XyloCor Therapeutics","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0.070000000000000007,"dosageForm":"Undisclosed","sponsorNew":"XyloCor Therapeutics \/ Jeito Capital","highestDevelopmentStatusID":"7","companyTruncated":"XyloCor Therapeutics \/ Jeito Capital"}]

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    Encoberminogene Rezmadenovec

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                            01

                            XyloCor Therapeutics

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                            XyloCor Therapeutics

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                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Jeito Capital

                            Deal Size : $67.5 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            XyloCor Secures $67.5M Series B for Cardiovascular Gene Therapy

                            Details : The financing will support the company in advancing the clinical development of XC001 (encoberminogene rezmadenovec) for the treating Refractory Angina.

                            Product Name : XC001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            January 07, 2025

                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Jeito Capital

                            Deal Size : $67.5 million

                            Deal Type : Series B Financing

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                            02

                            Exelixis

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Exelixis & Merck Collaborate on Zanzalintinib + KEYTRUDA® for Head/Neck Cancer & RCC

                            Details : The collaboration aims to evaluate Exelixis’ TKI XL092 (zanzalintinib) with Merck’s Keytruda (pembrolizumab) for HNSCC, and with Welireg (belzutifan), an oral HIF-2 alpha inhibitor, for RCC.

                            Product Name : XL092

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 14, 2024

                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

                            Arcus Biosciences

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                            Arcus Biosciences

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                            Lead Product(s) : Casdatifan,Encoberminogene Rezmadenovec

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Arcus Biosciences Secures Up to $250 Million Term Loan Facility from Hercules Capital

                            Details : The proceeds will be used to rapidly advance AB521 (casdatifan), its potential best-in-class HIF-2a inhibitor, for the treatment of renal cell cancer.

                            Product Name : AB521

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            August 27, 2024

                            Lead Product(s) : Casdatifan,Encoberminogene Rezmadenovec

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            04

                            XyloCor Therapeutics

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                            XyloCor Therapeutics

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                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XyloCor Therapeutics Reports Sustained Results in 12-Month Extension of Phase 2 EXACT Clinical Trial of XC001 ...

                            Details : XC001 (encoberminogene rezmadenovec) is designed to promote new blood vessels in the heart that will bypass diseased blood vessels and improve blood flow in patients with refractory angina.

                            Product Name : XC001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 18, 2023

                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Exelixis

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                            Exelixis

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Casdatifan

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Arcus Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Exelixis and Arcus Biosciences Announce Clinical Trial Collaboration to Evaluate Zanzalintinib in Combination ...

                            Details : The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.

                            Product Name : XL092

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 12, 2023

                            Lead Product(s) : Encoberminogene Rezmadenovec,Casdatifan

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Arcus Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            06

                            Exelixis

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Exelixis Announces Initiation of the STELLAR-305 Phase 2/3 Pivotal Trial Evaluating Zanzalintinib in Combinati...

                            Details : XL092 (Zanzalintinib) is a Vegf/metaxl/mer Inhibitor small molecule drug candidate, which is currently being evaluated in combination with "Pembrolizumab" for the treatment of PD-L1-positive recurrent or metastatic squamous cell carcinoma of the head and...

                            Product Name : XL092

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 12, 2023

                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            XyloCor Therapeutics

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                            XyloCor Therapeutics

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                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XyloCor Therapeutics Reports Positive Topline Safety and Efficacy Results from Phase 2 EXACT Clinical Trial of...

                            Details : XC001 is designed to promote new blood vessels in the heart that will bypass diseased blood vessels and improve blood flow. By restoring blood flow, it may decrease chest pain associated with refractory angina.

                            Product Name : XC001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 26, 2023

                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Exelixis

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Exelixis Announces Initiation of the STELLAR-304 Phase 3 Pivotal Trial Evaluating Zanzalintinib in Patients wi...

                            Details : Zanzalintinib, which was adopted as the generic name for XL092, is a next-generation tyrosine kinase inhibitor (TKI) in development for multiple advanced tumor types. Zanzalintinib is currently being developed for the treatment of advanced solid tumors.

                            Product Name : XL092

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 22, 2022

                            Lead Product(s) : Encoberminogene Rezmadenovec,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Exelixis

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Exelixis Announces Dose-Escalation Results from the Phase 1 STELLAR-001 Trial Evaluating XL092 Alone and in Co...

                            Details : XL092 demonstrated preliminary clinical activity similar to that observed with cabozantinib in phase 1 across a range of solid tumors and dose levels, with a manageable safety profile.

                            Product Name : XL092

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 09, 2022

                            Lead Product(s) : Encoberminogene Rezmadenovec,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            XyloCor Therapeutics

                            U.S.A arrow
                            STLE Annual Meeting
                            Not Confirmed

                            XyloCor Therapeutics

                            U.S.A arrow
                            STLE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            XyloCor Therapeutics Achieves Target Enrollment in Phase 2 EXACT Study of XC001 Novel Gene Therapy for Ischemi...

                            Details : XC001 (encoberminogene rezmadenovec) is a locally administered, single-dose gene therapy currently in development as a novel approach to treating patients with refractory angina who have no other medical and surgical options.

                            Product Name : XC001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 28, 2022

                            Lead Product(s) : Encoberminogene Rezmadenovec

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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