[{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Rivipansel","moa":"P-selectin","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Rivipansel","moa":"P-selectin","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Rivipansel","moa":"P-selectin","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Rivipansel","moa":"P-selectin","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Uproleselan","moa":"E-selectin","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"GMI-1359","moa":"E-selectin","graph1":"Oncology","graph2":"Phase I","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"GMI-1359","moa":"E-selectin","graph1":"Oncology","graph2":"Phase I","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"GMI-1359","moa":"E-selectin","graph1":"Oncology","graph2":"Phase I","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"The University of Texas MD Anderson Cancer Center","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ The University of Texas MD Anderson Cancer Center","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ The University of Texas MD Anderson Cancer Center"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"National Cancer Institute","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent 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Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph 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Diagnosis","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Crescent Biopharma \/ The Division of Cancer Treatment and Diagnosis","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ The Division of Cancer Treatment and Diagnosis"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Crescent Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Merger","leadProduct":"CR-001","moa":"PD-1\/VEGF","graph1":"Oncology","graph2":"Preclinical","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Crescent Biopharma \/ Crescent Biopharma","highestDevelopmentStatusID":"4","companyTruncated":"Crescent Biopharma \/ Crescent Biopharma"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"GMI-1757","moa":"E-selectin","graph1":"Oncology","graph2":"Preclinical","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Uproleselan","moa":"||E-selectin","graph1":"Oncology","graph2":"Phase III","graph3":"Crescent Biopharma","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Crescent Biopharma \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Crescent Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Crescent Biopharma","sponsor":"Crescent Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Merger","leadProduct":"CR-001","moa":"PD-1\/VEGF","graph1":"Oncology","graph2":"Preclinical","graph3":"Crescent 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                          Top Deals by Deal Size (USD bn)

                          01

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : Through the merger, the combined company will operate under the name Crescent Biopharma and will advance its pipeline activities, including CR-001, which is being evaluated for the treatment of NSCLC.

                          Product Name : CR-001

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 16, 2025

                          Lead Product(s) : CR-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Crescent Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : The proceeds from the placement will used to advance the clinical development of CR-001, which is being evaluated for the treatment of Non-Small Cell Lung Cancer.

                          Product Name : CR-001

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 16, 2025

                          Lead Product(s) : CR-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Fairmount

                          Deal Size : $200.0 million

                          Deal Type : Private Placement

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                          03

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : GMI-1271 (uproleselan) is a E-selectin inhibitor, which is being evaluated to treat adults with newly diagnosed acute myeloid leukemia (AML) who are 60 years or older.

                          Product Name : GMI-1271

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 29, 2024

                          Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : The Division of Cancer Treatment and Diagnosis

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : The combined company will advance Crescent’s portfolio of precision-engineered biologics including its lead program CR-001, a tetravalent PD-1 x VEGF bispecific antibody.

                          Product Name : CR-001

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : CR-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Crescent Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          05

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : GMI-1271 (uproleselan) is an investigational, first-in-class E-selectin antagonist, which is under phase 3 clinical development for adults with relapsed or refractory acute myeloid leukemia.

                          Product Name : GMI-1271

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 05, 2024

                          Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : GMI-1271 (uproleselan) is a first-in-class E-selectin antagonist, which is under phase 3 development for the treatment of of adults with relapsed or refractory acute myeloid leukemia.

                          Product Name : GMI-1271

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 06, 2024

                          Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : GMI-1687 is a highly potent E-selectin antagonist that is bioavailable after subcutaneous administration. It is under phase 1 clinical development for the treatment of sickle cell disease.

                          Product Name : GMI-1687

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 01, 2024

                          Lead Product(s) : Uproleselan

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : GMI-1271 (uproleselan) is designed to bind to E-selection and block the normal processes controlled by E-selectin. E-selectin is expressed on the surface of blood vessels, and its binding to myeloid cells confers a pro-survival effect via NF-kB signaling...

                          Product Name : GMI-1271

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 15, 2023

                          Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance within the bone marrow microe...

                          Product Name : GMI-1271

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 15, 2021

                          Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Specialty & Agro Chemical
                          Not Confirmed
                          Specialty & Agro Chemical
                          Not Confirmed

                          Details : The study demonstrates that GMI-1757 significantly improved anti-PD-L1 therapeutic activity in a pancreatic adenocarcinoma model.

                          Product Name : GMI-1757

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 04, 2021

                          Lead Product(s) : GMI-1757

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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