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Medicine","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Undisclosed","year":"2020","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Discovery","graph3":"Astellas Pharma","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Astellas Pharma \/ Astellas Pharma","highestDevelopmentStatusID":"2","companyTruncated":"Astellas Pharma \/ Astellas Pharma"}]

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                          01

                          Global ChemShow
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                          Global ChemShow
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                          Details : Avacincaptad Pegol is a Oligonucleotide drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Geographic Atrophy.

                          Product Name : Undisclosed

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 14, 2025

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Global ChemShow
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                          Global ChemShow
                          Not Confirmed

                          Details : Izervay (avacincaptad pegol intravitreal solution), a complement C5 inhibitor is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : Izervay (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 05, 2025

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : Izervay (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          January 08, 2025

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : IZERVAY (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          November 19, 2024

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : IZERVAY™ (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Zimura

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          September 18, 2023

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Recipient : IVERIC bio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : Izervay (avacincaptad pegol intravitreal solution) act as completent C5 inhibitor that is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          August 18, 2023

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Recipient : Astellas Pharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : IZERVAY (avacincaptad pegol intravitreal solution) act as completent C5 inhibitor that is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                          Product Name : Izervay

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          August 04, 2023

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : Through the acquisition, Astellas expands its ophthalmology pipeline through Iveric Bio's promising programs, including Zimura (avacincaptad pegol), an important program for Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).

                          Product Name : Zimura

                          Product Type : Oligonucleotide

                          Upfront Cash : $5,900.0 million

                          July 11, 2023

                          Lead Product(s) : Avacincaptad Pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Recipient : IVERIC bio

                          Deal Size : $5,900.0 million

                          Deal Type : Acquisition

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                          10

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : Astellas gains rights to utilize the intravitreal retinotropic R100 adeno-associated virus vector invented by 4DMT for one genetic target implicated in rare monogenic ophthalmic diseases, with options to add up to two additional targets implicated for th...

                          Product Name : Undisclosed

                          Product Type : Microorganism

                          Upfront Cash : $20.0 million

                          July 10, 2023

                          Lead Product(s) : Adeno-associated Virus Vector

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Undisclosed

                          Recipient : 4D Molecular Therapeutics

                          Deal Size : $962.5 million

                          Deal Type : Licensing Agreement

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