- About The Company
Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Currently, they have exclusive partnerships with mul...
Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Currently, they have exclusive partnerships with multiple, state-of-the-art and GMP-compliant manufacturers in China and abroad to service our esteemed partners for competitive, long-term & stable supplies. The main products are APIs and intermediates of antiviral drug substances and anti-inflammatory, analgesic, and non-steroidal pharmaceuticals.
Looking for 1661854-97-2 / CLN-081 API manufacturers, exporters & distributors?
CLN-081 manufacturers, exporters & distributors
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PharmaCompass offers a list of CLN-081 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CLN-081 manufacturer or CLN-081 supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CLN-081 manufacturer or CLN-081 supplier.
PharmaCompass also assists you with knowing the CLN-081 API Price utilized in the formulation of products. CLN-081 API Price is not always fixed or binding as the CLN-081 Price is obtained through a variety of data sources. The CLN-081 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
API | Excipient name
CLN-081
Synonyms
Tas6417, 1661854-97-2, Zipalertinib, Tas-6417, Zipalertinib [inn], T4ymu8tw9h
Unique Ingredient Identifier (UNII)
T4YMU8TW9H
About CLN-081
Zipalertinib is an orally available selective inhibitor of a broad spectrum of epidermal growth factor receptor (EGFR) mutations, including EGFR exon 20 insertion mutations (EGFR Ex20ins; Ex20ins mutations), with potential antineoplastic activity. CLN-081 is also active against other EGFR mutations including exon 19 deletions (exon19del), L858R, and T790M, as well as the less common G719X, L861Q and S768I mutations. Upon administration, zipalertinib specifically and covalently binds to and inhibits a variety of EGFR mutations, with particularly high selectivity against EGFR Ex20ins, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CLN-081 may have therapeutic benefits in tumors with EGFR Ex20ins, as most EGFR mutant-selective inhibitors are not active against EGFR Ex20ins. This agent shows minimal activity against wild-type EGFR (wt EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit wt EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
CLN-081 Manufacturers
A CLN-081 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CLN-081, including repackagers and relabelers. The FDA regulates CLN-081 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CLN-081 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of CLN-081 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
CLN-081 Suppliers
A CLN-081 supplier is an individual or a company that provides CLN-081 active pharmaceutical ingredient (API) or CLN-081 finished formulations upon request. The CLN-081 suppliers may include CLN-081 API manufacturers, exporters, distributors and traders.
click here to find a list of CLN-081 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
CLN-081 Manufacturers | Traders | Suppliers
CLN-081 Manufacturers, Traders, Suppliers
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We have 1 companies offering CLN-081
Get in contact with the supplier of your choice:
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Shanghai Hope Chem
Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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