Finished Dosage Form (FDF) import of Vildagliptin obtained from Indian Custom Trade Statistics

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ACTIVE PHARMA INGREDIENTS

103 API Suppliers, 19 USDMF, 10 JDMF, 31 EU WC, 22 KDMF, 5 NDC API, 75 Listed Suppliers, $ API Reference Price

103 API Suppliers
19 USDMF
10 JDMF
31 EU WC
22 KDMF
5 NDC API
75 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

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8 Drugs in Development

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46 Intermediates Suppliers

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FINISHED DOSAGE FORMULATIONS

113 FDF Dossiers, 67 Europe, 2 Australia, 13 South Africa, 31 Listed Dossiers

113 FDF Dossiers
67 Europe
2 Australia
13 South Africa
31 Listed Dossiers

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56 Finished Drug Prices, 2 Annual Reports

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56 Finished Drug Prices
2 Annual Reports

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35 APIs, 8 FDF Dossiers

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8 FDF Dossiers

REF. STANDARDS & IMPURITIES

11 Others

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ANALYTICAL

1 BioAnalytical Methods

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1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

103

API Suppliers

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CEP/COS

JDMF

EU WC

KDMF

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API REF. PRICE (USD/KG)

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FDF

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113

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FDA Orange Book

Europe

Canada

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South Africa

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Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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GLOBAL SALES INFORMATION

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Annual Reports (USD Million)

902

Finished Drug Prices

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Chemistry

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Also known as: Vildagliptin, 274901-16-5, (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile, Vildagliptin (2r)-isomer, Schembl671629, Dtxsid301119534

Molecular Formula

C₁₇H₂₅N₃O₂

Molecular Weight

303.4 g/mol

InChI Key

SYOKIDBDQMKNDQ-JULPFRMLSA-N

A pyrrolidine-carbonitrile derivative and potent inhibitor of DIPEPTIDYL PEPTIDASE 4 that is used in the treatment of TYPE 2 DIABETES MELLITUS.

1 2D Structure

Vildagliptin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

2.1.2 InChI

InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m1/s1

2.1.3 InChI Key

SYOKIDBDQMKNDQ-JULPFRMLSA-N

2.1.4 Canonical SMILES

C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N

2.1.5 Isomeric SMILES

C1C[C@@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. (2s)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

2. Galvus

3. Nvp Laf237

4. Nvp-laf237

5. Vildagliptin

2.2.2 Depositor-Supplied Synonyms

1. Vildagliptin

2. 274901-16-5

3. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

4. Vildagliptin (2r)-isomer

5. Schembl671629

6. Dtxsid301119534

7. Akos015969326

8. F78360

9. A819091

10. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]-1-oxoethyl]-2-pyrrolidinecarbonitrile

11. (2r)-1-[2-[(3-oxidanyl-1-adamantyl)amino]ethanoyl]pyrrolidine-2-carbonitrile

12. (2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine Carbonitrile; (r)-1-(2-(((1r,3s,5r,7s)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

13. Rel-(2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile

2.2.3 Other Synonyms

1. Jalra

2. Equa

2.3 Create Date

2008-07-11

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₅N₃O₂
Molecular Weight	303.4 g/mol
XLogP3	0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	303.19467705 g/mol
Monoisotopic Mass	303.19467705 g/mol
Topological Polar Surface Area	76.4 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	523
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance. in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control

Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

- as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

- in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control (see sections 4. 4, 4. 5 and 5. 1 for available data on different combinations).

Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

- as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

Treatment of type II diabetes mellitus

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dipeptidyl-Peptidase IV Inhibitors

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)

Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

5.2 ATC Code

A10BH02

A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10B - Blood glucose lowering drugs, excl. insulins

A10BH - Dipeptidyl peptidase 4 (dpp-4) inhibitors

A10BH02 - Vildagliptin

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API Reference Price

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