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Chemistry

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Also known as: 53885-35-1, Ticlopidine hcl, Ticlid, Ticlodix, Ticlodone, Panaldine
Molecular Formula
C14H15Cl2NS
Molecular Weight
300.2  g/mol
InChI Key
MTKNGOHFNXIVOS-UHFFFAOYSA-N
FDA UNII
A1L4914FMF

Ticlopidine
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
1 2D Structure

Ticlopidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine;hydrochloride
2.1.2 InChI
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H
2.1.3 InChI Key
MTKNGOHFNXIVOS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
A1L4914FMF
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 53 32c

2. 53-32c

3. 5332c

4. Hydrochloride, Ticlopidine

5. Ticlid

6. Ticlodix

7. Ticlodone

8. Ticlopidine

2.3.2 Depositor-Supplied Synonyms

1. 53885-35-1

2. Ticlopidine Hcl

3. Ticlid

4. Ticlodix

5. Ticlodone

6. Panaldine

7. Tiklid

8. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

9. Ipaton

10. Ticlopidine (hydrochloride)

11. 53-32c

12. 4-c-32

13. Nsc-759165

14. Mls000083578

15. A1l4914fmf

16. Tiklyd

17. Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride

18. Smr000048468

19. 5-[(2-chlorophenyl)methyl]-4h,5h,6h,7h-thieno[3,2-c]pyridine Hydrochloride

20. Chebi:9589

21. 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4h-thieno[3,2-c]pyridine;hydrochloride

22. Ticlopidinehydrochloride

23. Einecs 258-837-4

24. Unii-a1l4914fmf

25. Aplaket

26. Sr-01000003130

27. Ticlopidine, Hcl

28. Prestwick_502

29. Mfcd00079606

30. Ticlid (tn)

31. 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

32. Ticlopidine Hydrochloride [usan:usp:jan]

33. Opera_id_1799

34. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno-(3,2-c)pyridine Hydrochloride

35. Chembl1717

36. Schembl33596

37. Mls000028579

38. Mls001401394

39. Ticlopidine Hydrochloride,(s)

40. Hy-b0153a

41. Dtxsid80202141

42. Hms1568i15

43. Pharmakon1600-01505677

44. Bcp23429

45. Nsc759165

46. S1984

47. Ticlopidine Hydrochloride [mi]

48. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride

49. Akos015905580

50. Ticlopidine Hydrochloride (jp17/usp)

51. Ac-8973

52. Ccg-101023

53. Cs-1985

54. Nc00273

55. Nsc 759165

56. Ticlopidine Hydrochloride [jan]

57. Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-, Hydrochloride

58. Ticlopidine Hydrochloride [usan]

59. Ticlopidine Hydrochloride [mart.]

60. Ticlopidine Hydrochloride [vandf]

61. As-10890

62. Bt164472

63. Ticlopidine Hydrochloride [usp-rs]

64. Ticlopidine Hydrochloride [who-dd]

65. Bcp0726000288

66. Ft-0630664

67. T3110

68. D01028

69. I11518

70. Ticlopidine Hydrochloride [ep Impurity]

71. Ticlopidine Hydrochloride [ep Monograph]

72. Ticlopidine Hydrochloride [orange Book]

73. Ticlopidine Hydrochloride [usp Monograph]

74. 885t351

75. Sr-01000003130-6

76. W-105699

77. Q27108439

78. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hcl

79. Ticlopidine Hydrochloride, Analytical Standard, For Drug Analysis

80. 5-(2-chloro-benzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Hydrochloride

81. 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinehydrochloride

82. Ticlopidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

83. 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine Hydrochloride

84. 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine Hydrochloride

85. Ticlopidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 300.2 g/mol
Molecular Formula C14H15Cl2NS
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass299.0302260 g/mol
Monoisotopic Mass299.0302260 g/mol
Topological Polar Surface Area31.5 Ų
Heavy Atom Count18
Formal Charge0
Complexity261
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTiclopidine hydrochloride
Drug LabelTiclopidine hydrochloride is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is:C14H14ClNS HCl M.W. 300.25Ticlopidine hydrochloride is a...
Active IngredientTiclopidine hydrochloride
Dosage FormTablet
RouteOral
Strength250mg
Market StatusPrescription
CompanyTeva; Apotex; Sun Pharm Inds

2 of 2  
Drug NameTiclopidine hydrochloride
Drug LabelTiclopidine hydrochloride is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is:C14H14ClNS HCl M.W. 300.25Ticlopidine hydrochloride is a...
Active IngredientTiclopidine hydrochloride
Dosage FormTablet
RouteOral
Strength250mg
Market StatusPrescription
CompanyTeva; Apotex; Sun Pharm Inds

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)


Fibrinolytic Agents

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)


Cytochrome P-450 CYP2C19 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19. (See all compounds classified as Cytochrome P-450 CYP2C19 Inhibitors.)


Purinergic P2Y Receptor Antagonists

Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes. (See all compounds classified as Purinergic P2Y Receptor Antagonists.)


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Aarti Drugs Ltd

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DMF Number : 22355

Submission : 2008-12-30

Status : Inactive

Type : II

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Curia Italy Srl

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Erregierre Spa

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Roche Palo Alto Llc

Switzerland

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Roche Palo Alto Llc

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DMF Number : 8092

Submission : 1989-06-01

Status : Inactive

Type : II

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Orgamol Sa

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Orgamol Sa

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DMF Number : 3599

Submission : 1979-08-22

Status : Inactive

Type : II

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Submission : 1993-09-15

Status : Active

Type : II

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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CEP 2000-052 - Rev 03
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2024-02-07
1050
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Certificate Number : CEP 2000-052 - Rev 03

Status : Valid

Issue Date : 2024-02-07

Type : Chemical

Substance Number : 1050

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Certificate Number : CEP 2002-116 - Rev 03

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Certificate Number : R1-CEP 2003-066 - Rev 01

Status : Withdrawn by Holder

Issue Date : 2013-07-04

Type : Chemical

Substance Number : 1050

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Certificate Number : R1-CEP 2002-106 - Rev 02

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Type : Chemical

Substance Number : 1050

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Certificate Number : R1-CEP 2001-379 - Rev 05

Status : Valid

Issue Date : 2022-01-04

Type : Chemical

Substance Number : 1050

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Certificate Number : R1-CEP 2001-414 - Rev 02

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Issue Date : 2011-03-03

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Substance Number : 1050

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USV Limited Mumbai IN

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USV Limited Mumbai IN

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Certificate Number : R1-CEP 2002-039 - Rev 00

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Issue Date : 2008-05-19

Type : Chemical

Substance Number : 1050

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Certificate Number : R1-CEP 2004-109 - Rev 03

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Substance Number : 1050

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API Reference Price

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29-Jan-2021
30-Aug-2024
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