Global sales information and US Prescriptions data of Dorzolamide Hydrochloride obtained from Centers for Medicare & Medicaid Services Website

Dorzolamide Hydrochloride

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ACTIVE PHARMA INGREDIENTS

36 API Suppliers, 14 USDMF, 13 CEP/COS, 4 JDMF, 8 EU WC, 12 KDMF, 14 NDC API, 26 Listed Suppliers, $ API Reference Price

36 API Suppliers
14 USDMF
13 CEP/COS
4 JDMF
8 EU WC
12 KDMF
14 NDC API
26 Listed Suppliers
$ API Reference Price

INTERMEDIATES

9 Intermediates Suppliers

9 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

173 FDF Dossiers, 35 FDA Orange Book, 96 Europe, 17 Canada, 4 Australia, 7 South Africa, 14 Listed Dossiers

173 FDF Dossiers
35 FDA Orange Book
96 Europe
17 Canada
4 Australia
7 South Africa
14 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE;EQ 0.5% BASE

drugProductComposition
SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE;EQ 0.5% BASE

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 3 DKSH, 1 Pfanstiehl, 4 Actylis, 1 BASF, 1 Finar, 2 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
12 SPI Pharma
3 DKSH
1 Pfanstiehl
4 Actylis
1 BASF
1 Finar
2 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Pluviaendo
3 Roquette
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 9 Direct Compression, 5 Parenteral, 4 Thickeners and Stabilizers, 3 Granulation, 3 Topical, 3 Rheology Modifiers, 3 Co-Processed Excipients, 3 Disintegrants & Superdisintegrants, 2 Solubilizers, 2 Controlled & Modified Release, 1 API Stability Enhancers

excipientsByApplications
17 Fillers, Diluents & Binders
10 Chewable & Orodispersible Aids
9 Taste Masking
9 Direct Compression
5 Parenteral
4 Thickeners and Stabilizers
3 Granulation
3 Topical
3 Rheology Modifiers
3 Co-Processed Excipients
3 Disintegrants & Superdisintegrants
2 Solubilizers
2 Controlled & Modified Release
1 API Stability Enhancers

DIGITAL CONTENT

16 NEWS #PharmaBuzz

media
16 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 US Medicaid Prescriptions, 76 Finished Drug Prices

globalSalesInformation
4 US Medicaid Prescriptions
76 Finished Drug Prices

MARKET PLACE

14 APIs, 1 FDF Dossiers

marketPlace
14 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 4 USP , 4 JP , 6 Others

otherSolutions
3 EDQM
4 USP
4 JP
6 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 3,161

MARKET PLACE

API

FDF

9INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

173

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

37,828,352

Annual Reports (USD Million)

Finished Drug Prices

37 RELATED EXCIPIENT COMPANIES

74EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 130693-82-2, Dorzolamide hcl, Trusopt, Dorzolomide hydrochloride, Cosopt, Dorzolamide (hydrochloride)

Molecular Formula

C₁₀H₁₇ClN₂O₄S₃

Molecular Weight

360.9 g/mol

InChI Key

OSRUSFPMRGDLAG-QMGYSKNISA-N

FDA UNII

QZO5366EW7

Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)

1 2D Structure

Dorzolamide Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride

2.1.2 InChI

InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

2.1.3 InChI Key

OSRUSFPMRGDLAG-QMGYSKNISA-N

2.1.4 Canonical SMILES

CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl

2.1.5 Isomeric SMILES

CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl

2.2 Other Identifiers

2.2.1 UNII

QZO5366EW7

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-ethylamino-5,6-dihydro-6-methyl-7,7-dioxide-4h-thieno(2,3-b)thiopyran-2-sulfonamide

2. 5,6-dihydro-4-ethylamino-6-methyl-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide

3. Dorzolamide

4. Dorzolamide Chibret

5. Dorzolamide, (trans)-isomer

6. L 671152

7. L-671,152

8. Mk 507

9. Mk-507

10. Trusopt

2.3.2 Depositor-Supplied Synonyms

1. 130693-82-2

2. Dorzolamide Hcl

3. Trusopt

4. Dorzolomide Hydrochloride

5. Cosopt

6. Dorzolamide (hydrochloride)

7. Mk-507

8. Dorzolomide Hcl

9. (4s,6s)-4-(ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide Hydrochloride

10. Dorzolamide (as Hydrochloride)

11. Qzo5366ew7

12. Trusopt (tn)

13. Dsstox_cid_25530

14. Dsstox_rid_80933

15. Dsstox_gsid_45530

16. (4s,6s)-4-(ethylamino)-5,6-dihydro-6-methyl-4h-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide, Monohydrochloride

17. Chebi:4703

18. (4s,6s)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride

19. 4h-thieno(2,3-b)thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, Monohydrochloride, (4s-trans)-

20. Unii-qzo5366ew7

21. Sr-05000001449

22. Dorzolamide Hydrochloride [usan]

23. L 671152

24. L-671,152

25. Dorzolamide Hcl Salt

26. Dorzolamide Hydrochloride [usan:usp]

27. Mk507 Hydrochloride

28. Mk 0507

29. Mk-0507

30. L671152 Hydrochloride

31. Ncgc00016977-01

32. Cas-130693-82-2

33. Schembl41152

34. Mls002154162

35. Chembl1201162

36. Dtxsid1045530

37. Dorzolamide Hydrochloride- Bio-x

38. Hy-b0109a

39. Hms1571o14

40. Ex-a3987

41. Tox21_110720

42. Mfcd00884659

43. S1375

44. Dorzolamide Hydrochloride [mi]

45. Akos005146235

46. Akos015895951

47. Dorzolamide Hydrochloride (jp17/usp)

48. Tox21_110720_1

49. Ac-5244

50. Ccg-221116

51. Cs-1858

52. Dorzolamide Hydrochloride [jan]

53. Ks-1348

54. Dorzolamide Hydrochloride [mart.]

55. Dorzolamide Hydrochloride [vandf]

56. Ncgc00179244-03

57. Bd164381

58. Dorzolamide Hydrochloride [usp-rs]

59. Dorzolamide Hydrochloride [who-dd]

60. Smr001233461

61. Mk-507 (l-671152) Hcl

62. D4189

63. Dorzolamide Hydrochloride, Trans-(-)-

64. C72221

65. D00653

66. Dorzolamide Hydrochloride [orange Book]

67. Dorzolamide Hydrochloride [usp Impurity]

68. Cosopt Component Dorzolamide Hydrochloride

69. Dorzolamide Hydrochloride [usp Monograph]

70. 279d961

71. Dorzolamide Hydrochloride Component Of Cosopt

72. L-671152

73. Sr-05000001449-3

74. Q27106441

75. Dorzolamide Hydrochloride, European Pharmacopoeia (ep) Reference Standard

76. Dorzolamide For System Suitability, European Pharmacopoeia (ep) Reference Standard

77. Dorzolamide Hydrochloride, United States Pharmacopeia (usp) Reference Standard

78. (4s,6s)-4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide 4h-thieno[2,3-b]thiopyran-2-sulfonamide Hydrochloride

79. 122028-16-4

80. 4h-thieno(2,3-b)thiopyran-2-sulfonamide, 5,6-dihydro-4-(ethylamino)-6-methyl-, 7,7-dioxide, Monohydrochloride, (4s,6s)-

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₇ClN₂O₄S₃
Molecular Weight	360.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	360.0038982 g/mol
Monoisotopic Mass	360.0038982 g/mol
Topological Polar Surface Area	151 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	534
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Cosopt
PubMed Health	Dorzolamide/Timolol (Into the eye)
Drug Classes	Antiglaucoma, Beta-Adrenergic Blocker/Carbonic Anhydrase Inhibitor Combination
Active Ingredient	Dorzolamide hydrochloride; timolol maleate
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base; eq 2% base
Market Status	Prescription
Company	Oak Pharms Akorn

2 of 4
Drug Name	Dorzolamide hydrochloride
Drug Label	Dorzolamide Hydrochloride Ophthalmic Solution USP, 2% is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.Dorzolamide hydrochloride, USP is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]th...
Active Ingredient	Dorzolamide hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 2% base
Market Status	Prescription
Company	Watson Labs; Zach Systems; Teva Pharms; Hi Tech Pharma; Bausch And Lomb; Alcon Pharms; Luitpold; Sandoz

3 of 4
Drug Name	Cosopt
PubMed Health	Dorzolamide/Timolol (Into the eye)
Drug Classes	Antiglaucoma, Beta-Adrenergic Blocker/Carbonic Anhydrase Inhibitor Combination
Active Ingredient	Dorzolamide hydrochloride; timolol maleate
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base; eq 2% base
Market Status	Prescription
Company	Oak Pharms Akorn

4 of 4
Drug Name	Dorzolamide hydrochloride
Drug Label	Dorzolamide Hydrochloride Ophthalmic Solution USP, 2% is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.Dorzolamide hydrochloride, USP is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]th...
Active Ingredient	Dorzolamide hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 2% base
Market Status	Prescription
Company	Watson Labs; Zach Systems; Teva Pharms; Hi Tech Pharma; Bausch And Lomb; Alcon Pharms; Luitpold; Sandoz

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Carbonic Anhydrase Inhibitors

A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (See all compounds classified as Carbonic Anhydrase Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Carbonic Anhydrase Inhibitors [MoA]; Carbonic Anhydrase Inhibitor [EPC]

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API Reference Price

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OFFICE: NO. 16\/2,","city":"BANGALORE, KARNATAKA","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"SOMERSET THERAPEUTICS LIMITED","customerCountry":"INDIA","quantity":"45.55","actualQuantity":"45.545","unit":"KGS","unitRateFc":"3150","totalValueFC":"147800.5","currency":"USD","unitRateINR":"269486.2","date":"02-Aug-2024","totalValueINR":"12273750.83","totalValueInUsd":"147800.5","indian_port":"Bangalore Air","hs_no":"29359090","bill_no":"4839390","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PARQUE TECNOLOGICO DE BOECILLO PARCELA 105 47151 BOECILLO VALLADOLIDSPAIN Madrid, , Spain Spain","customerAddress":"REGD. OFFICE: NO. 16\/2,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

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Europe

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BA...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20408

DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BA...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE;EQ 0.5% BASE

USFDA APPLICATION NUMBER - 20869

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Fillers, Diluents & Binders

Chewable & Orodispersible Aids

Taste Masking

Direct Compression

Parenteral

Thickeners and Stabilizers

Granulation

Topical

Rheology Modifiers

Co-Processed Excipients

Disintegrants & Superdisintegrants

Solubilizers

Controlled & Modified Release

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NEWS #PharmaBuzz

Global Sales Information

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US Medicaid Prescriptions

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Finished Drug Prices

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EDQM

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Global sales information and US Prescriptions data of Dorzolamide Hydrochloride obtained from Centers for Medicare & Medicaid Services Website

Dorzolamide Hydrochloride

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

36 API Suppliers

14 USDMF

13 CEP/COS

4 JDMF

8 EU WC

12 KDMF

14 NDC API

26 Listed Suppliers

$ API Reference Price

INTERMEDIATES

9 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

173 FDF Dossiers

35 FDA Orange Book

96 Europe

17 Canada

4 Australia

7 South Africa

14 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE;EQ 0.5% BASE

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

12 SPI Pharma

3 DKSH

1 Pfanstiehl

4 Actylis

1 BASF

1 Finar

2 Gangwal Chemicals

1 Ingredion Pharma Solutions

2 Kerry

2 Microlex e.U

1 Pluviaendo

3 Roquette

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders

10 Chewable & Orodispersible Aids

9 Taste Masking

9 Direct Compression

5 Parenteral

4 Thickeners and Stabilizers

3 Granulation

3 Topical

3 Rheology Modifiers

3 Co-Processed Excipients

3 Disintegrants & Superdisintegrants

2 Solubilizers

2 Controlled & Modified Release

1 API Stability Enhancers

DIGITAL CONTENT

16 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 US Medicaid Prescriptions

76 Finished Drug Prices

MARKET PLACE

14 APIs

1 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM

4 USP

4 JP

6 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 3,161

MARKET PLACE

SOLUTION/DROPS;OPHTHALMIC - EQ 2% BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons