Find PharmaFlow Article for Carvedilol

PharmaCompass

Synopsis

0 DRUGS IN DEVELOPMENT

FDF DossiersDRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

JP

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

DIGITAL CONTENT

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

279 RELATED EXCIPIENT COMPANIES

493EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 72956-09-3, Coreg, Dilatrend, Eucardic, Kredex, Carvedilolum [latin]
Molecular Formula
C24H26N2O4
Molecular Weight
406.5  g/mol
InChI Key
OGHNVEJMJSYVRP-UHFFFAOYSA-N
FDA UNII
0K47UL67F2

Carvedilol
A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
Carvedilol is an alpha-Adrenergic Blocker and beta-Adrenergic Blocker. The mechanism of action of carvedilol is as an Adrenergic alpha-Antagonist and Adrenergic beta1-Antagonist and Adrenergic beta2-Antagonist.
1 2D Structure

Carvedilol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
2.1.2 InChI
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
2.1.3 InChI Key
OGHNVEJMJSYVRP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
2.2 Other Identifiers
2.2.1 UNII
0K47UL67F2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 14c-labeled Carvedilol

2. Bm 14190

3. Bm-14190

4. Bm14190

5. Carvedilol Hydrochloride

6. Carvedilol, (+)

7. Carvedilol, (+)-isomer

8. Carvedilol, (+-)-isomer

9. Carvedilol, (-)

10. Carvedilol, (-)-isomer

11. Carvedilol, (r)-isomer

12. Carvedilol, (s)-isomer

13. Carvedilol, 14c Labeled

14. Carvedilol, 14c-labeled

15. Coreg

16. Coropres

17. Dilatrend

18. Eucardic

19. Kredex

20. Querto

2.3.2 Depositor-Supplied Synonyms

1. 72956-09-3

2. Coreg

3. Dilatrend

4. Eucardic

5. Kredex

6. Carvedilolum [latin]

7. Carvedilolum

8. Querto

9. Bm 14190

10. 1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

11. Bm-14190

12. Dimitone

13. Artist

14. Skf 105517

15. 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

16. 1-((9h-carbazol-4-yl)oxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol

17. Coronis

18. Korvasan

19. Talliton

20. Dq 2466

21. Dq-2466

22. C07ag02

23. (+-)-1-(carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol

24. Chembl723

25. Nsc-758694

26. Sk&f-105517

27. Bm 14.190

28. Bm-14-190

29. Bm-14.190

30. Chebi:3441

31. 0k47ul67f2

32. [3-(9h-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine

33. 1-(9h-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol

34. Skf-105517

35. (r)-bm 14190

36. (s)-bm 14190

37. Coropress

38. Dibloc

39. R-(+)-carvedilol

40. S-(-)-carvedilol

41. 1-(9h-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol

42. Smr000449280

43. Artist (tn)

44. Coreg (tn)

45. Hsdb 7044

46. Sr-01000759289

47. Unii-0k47ul67f2

48. Mfcd00869663

49. 1-(9h-carbazol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol

50. Carvedilol D5

51. Eg-p042

52. Mfcd00864692

53. Carvedilol - Bio-x

54. Bm14190

55. Carvedilol [usan:usp:inn:ban:jan]

56. Spectrum_001665

57. Carvedilol [mi]

58. Carvedilol [inn]

59. Carvedilol [jan]

60. Spectrum2_001673

61. Spectrum3_001182

62. Spectrum4_000636

63. Spectrum5_001436

64. Carvedilol [hsdb]

65. Carvedilol [usan]

66. Carvedilol [vandf]

67. Carvedilol [mart.]

68. Carvedilol [usp-rs]

69. Carvedilol [who-dd]

70. Schembl22293

71. Gtpl551

72. Kbiogr_001252

73. Kbioss_002145

74. Mls000758299

75. Mls000759508

76. Mls001424092

77. Mls006011886

78. Spbio_001885

79. Carvedilol (jp17/usp/inn)

80. Carvedilol [orange Book]

81. Dtxsid8022747

82. Schembl10082334

83. Schembl13287211

84. Bdbm25759

85. Kbio2_002145

86. Kbio2_004713

87. Kbio2_007281

88. Kbio3_002323

89. Carvedilol [ep Monograph]

90. (r)-1-[(4-carbazolyl)oxy]-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

91. Carvedilol [usp Monograph]

92. Hms2051n03

93. Hms2089b09

94. Hms2093e12

95. Hms3261e15

96. Hms3269n11

97. Hms3393n03

98. Hms3413b14

99. Hms3655o14

100. Hms3677b14

101. Hms3715d15

102. Hms3750i15

103. Hms3884e12

104. Pharmakon1600-01504257

105. Carvedilol 1.0 Mg/ml In Methanol

106. ((c)i)-carvedilol-d4(ethyl-d4)

107. Amy40801

108. Bcp23386

109. Ex-a5746

110. Hy-b0006

111. Tox21_500347

112. Bbl029064

113. Mfcd00869664

114. Nsc758694

115. S1831

116. Stk621453

117. Akos005554967

118. Carvedilol, >=98% (hplc), Solid

119. Ac-1641

120. Bcp9000493

121. Ccg-100917

122. Ccg-207952

123. Cs-1194

124. Db01136

125. Ks-1037

126. Lp00347

127. Nc00167

128. Nsc 758694

129. Sb17441

130. Sdccgsbi-0206771.p002

131. 2-propanol, 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-

132. Ncgc00167832-01

133. Ncgc00167832-02

134. Ncgc00167832-03

135. Ncgc00167832-04

136. Ncgc00167832-19

137. Ncgc00261032-01

138. Bc164291

139. Sy129821

140. Sy283162

141. Bcp0726000253

142. Sbi-0206771.p001

143. Db-055704

144. Db-057556

145. Db-057557

146. Ft-0603055

147. Ft-0603057

148. Ft-0652640

149. Ft-0664397

150. Sw197547-3

151. C06875

152. D00255

153. F19969

154. Ab00639903-07

155. Ab00639903-09

156. Ab00639903_10

157. Ab00639903_11

158. Ab00639903_12

159. 956c093

160. L001243

161. Q412534

162. Q-200801

163. Sr-01000759289-5

164. Sr-01000759289-6

165. Sr-01000759289-9

166. Brd-a10977446-001-04-8

167. Brd-a10977446-001-05-5

168. Brd-a10977446-045-01-1

169. Z2786051695

170. Carvedilol, European Pharmacopoeia (ep) Reference Standard

171. Ethyl 2-(9-(pyridin-4-ylmethyl)-9h-fluoren-9-yl)acetate

172. Carvedilol, United States Pharmacopeia (usp) Reference Standard

173. 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol

174. Carvedilol, Pharmaceutical Secondary Standard; Certified Reference Material

175. (+/-)-1-carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol

176. 1-(carbazol-4-yloxy)-3-((2-(o-methoxy-phenoxy)ethyl)amino)-2-propanol

177. Carvedilol For System Suitability, European Pharmacopoeia (ep) Reference Standard

178. 107741-96-8

179. 2-propanol, 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+/-)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 406.5 g/mol
Molecular Formula C24H26N2O4
XLogP34.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass406.18925731 g/mol
Monoisotopic Mass406.18925731 g/mol
Topological Polar Surface Area75.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameCarvedilol
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelCarvedilol is a nonselective -adrenergic blocking agent with 1-blocking activity. It is ()-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol. Carvedilol is a racemic mixture with the following structure:Carvedilol tablets, US...
Active IngredientCarvedilol
Dosage FormTablet
RouteOral
Strength6.25mg; 25mg; 3.125mg; 12.5mg
Market StatusPrescription
CompanyRanbaxy; Glenmark Generics; Teva; Apotex; Aurobindo Pharma; Sun Pharm Inds; Beximco Usa; Pliva Hrvatska Doo; Taro; Lupin; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Cipla; Mylan; Hikma

2 of 6  
Drug NameCoreg
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelCarvedilol is a nonselective -adrenergic blocking agent with 1-blocking activity. It is ()-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol. Carvedilol is a racemic mixture with the following structure:COREG is a white, oval...
Active IngredientCarvedilol
Dosage FormTablet
RouteOral
Strength6.25mg; 25mg; 3.125mg; 12.5mg
Market StatusPrescription
CompanySmithkline Beecham

3 of 6  
Drug NameCoreg cr
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Active IngredientCarvedilol phosphate
Dosage FormCapsule, extended release
RouteOral
Strength10mg; 80mg; 40mg; 20mg
Market StatusPrescription
CompanySb Pharmco

4 of 6  
Drug NameCarvedilol
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelCarvedilol is a nonselective -adrenergic blocking agent with 1-blocking activity. It is ()-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol. Carvedilol is a racemic mixture with the following structure:Carvedilol tablets, US...
Active IngredientCarvedilol
Dosage FormTablet
RouteOral
Strength6.25mg; 25mg; 3.125mg; 12.5mg
Market StatusPrescription
CompanyRanbaxy; Glenmark Generics; Teva; Apotex; Aurobindo Pharma; Sun Pharm Inds; Beximco Usa; Pliva Hrvatska Doo; Taro; Lupin; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Cipla; Mylan; Hikma

5 of 6  
Drug NameCoreg
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelCarvedilol is a nonselective -adrenergic blocking agent with 1-blocking activity. It is ()-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol. Carvedilol is a racemic mixture with the following structure:COREG is a white, oval...
Active IngredientCarvedilol
Dosage FormTablet
RouteOral
Strength6.25mg; 25mg; 3.125mg; 12.5mg
Market StatusPrescription
CompanySmithkline Beecham

6 of 6  
Drug NameCoreg cr
PubMed HealthCarvedilol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Active IngredientCarvedilol phosphate
Dosage FormCapsule, extended release
RouteOral
Strength10mg; 80mg; 40mg; 20mg
Market StatusPrescription
CompanySb Pharmco

4.2 Therapeutic Uses

Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Vasodilator Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)


Carvedilol is indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization. /Included in US product label/

US Natl Inst Health; DailyMed. Current Medication Information for CARVEDILOL (carvedilol) tablet (May 2011). Available from, as of September 19, 2011: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0b802a9c-332f-4ea8-bb34-75c677264654


Carvedilol is indicated to reduce cardiovasc