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    Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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    Axplora- The partner of choice for complex APIs.

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    Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

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    Chemistry

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    Also known as: Pulmicort, Entocort, Rhinocort, 51333-22-3, Preferid, Rhinocort aqua
    Molecular Formula
    C25H34O6
    Molecular Weight
    430.5  g/mol
    InChI Key
    VOVIALXJUBGFJZ-KWVAZRHASA-N
    FDA UNII
    Q3OKS62Q6X
    Budesonide
    A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
    Budesonide is a Corticosteroid. The mechanism of action of budesonide is as a Corticosteroid Hormone Receptor Agonist.
    1 2D Structure

    Budesonide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
    2.1.2 InChI
    InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
    2.1.3 InChI Key
    VOVIALXJUBGFJZ-KWVAZRHASA-N
    2.1.4 Canonical SMILES
    CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
    2.1.5 Isomeric SMILES
    CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C
    2.2 Other Identifiers
    2.2.1 UNII
    Q3OKS62Q6X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Budesonide, (r)-isomer

    2. Budesonide, (s)-isomer

    3. Horacort

    4. Pulmicort

    5. Rhinocort

    6. Tarpeyo

    2.3.2 Depositor-Supplied Synonyms

    1. Pulmicort

    2. Entocort

    3. Rhinocort

    4. 51333-22-3

    5. Preferid

    6. Rhinocort Aqua

    7. Entocort Ec

    8. Uceris

    9. Pulmicort Respules

    10. Respules

    11. Budeson

    12. Pulmicort Flexhaler

    13. Cortivent

    14. Micronyl

    15. Spirocort

    16. Bidien

    17. S-1320

    18. Map-0010

    19. Chebi:3207

    20. Q3oks62q6x

    21. 51372-29-3

    22. Mls000028507

    23. Budesonide Mmx

    24. Budesonidum

    25. Rhinocort Alpha

    26. Map0010

    27. R01ad05

    28. (11beta,16alpha)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

    29. 16a(r),17-(butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione

    30. Nsc-757788

    31. Budenofalk

    32. Budesonido

    33. Smr000058337

    34. Budecort Inhaler

    35. Budesonidum [inn-latin]

    36. Budesonido [inn-spanish]

    37. (r)-budesonide

    38. Inflammide

    39. Budiair

    40. Miflonide

    41. Pulmaxan

    42. Fvolir

    43. 16,17-butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

    44. Budesonide [usan:inn:ban:jan]

    45. Rhinocort Allergy

    46. Pulmaxan Turbohaler

    47. Pulmicort (tn)

    48. Pulmicort Topinasal

    49. Rhinocort (tn)

    50. Pulmicort Turbuhaler

    51. Budesonide Easyhaler

    52. S 1320

    53. Ccris 5230

    54. Entocort Ec (tn)

    55. Sr-01000000101

    56. Einecs 257-139-7

    57. Mfcd00083259

    58. Unii-q3oks62q6x

    59. Jorveza

    60. Eltair

    61. Ultesa

    62. Noex

    63. Giona Easyhaler

    64. 16?,17-[(1rs)-butylidenebis(oxy)]-11?,21-dihydroxypregna-1,4-diene-3,20-dione

    65. Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11.beta.,16.alpha.)-

    66. Prestwick_840

    67. Uceris (tn)

    68. Ortikos

    69. (11-beta,16-alpha)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

    70. 16-alpha,17-alpha-butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

    71. (rs)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Butyraldehyde

    72. Budesonide, >=99%

    73. Budesonide [mi]

    74. Budesonide [inn]

    75. Budesonide [jan]

    76. Opera_id_1696

    77. Prestwick0_000518

    78. Prestwick1_000518

    79. Prestwick2_000518

    80. Prestwick3_000518

    81. Budesonide [usan]

    82. Budesonide [vandf]

    83. Epitope Id:161750

    84. B 7777

    85. Schembl4096

    86. (+)-16alpha,17alpha-butylidenedioxy-11beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

    87. Budesonide [usp-rs]

    88. Budesonide [who-dd]

    89. Chembl1370

    90. Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-

    91. Lopac0_000174

    92. Bspbio_000475

    93. Budesonide (jan/usp/inn)

    94. Mls001077323

    95. Mls002207112

    96. Spbio_002396

    97. Bpbio1_000523

    98. Gtpl7434

    99. Budesonide [orange Book]

    100. Dtxsid8020202

    101. Hsdb 8279

    102. Budesonide [ep Monograph]

    103. Uceris Component Budesonide

    104. Budesonide [usp Monograph]

    105. Hms1569h17

    106. Hms2096h17

    107. Hms2232d17

    108. Hms3259h07

    109. Hms3260d09

    110. Hms3413b08

    111. Hms3413p17

    112. Hms3677b08

    113. Hms3677p17

    114. Hms3713h17

    115. Breztri Component Budesonide

    116. (rs)-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Butyraldehyde

    117. 5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2h-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

    118. Act03247

    119. Bcp05589

    120. Eohilia (budesonide Oral Suspension)

    121. Tox21_500174

    122. Bdbm50354850

    123. Symbicort Component Budesonide

    124. Budesonide Component Of Uceris

    125. Akos015969655

    126. Budesonide Component Of Breztri

    127. Ac-4697

    128. Ccg-204269

    129. Cs-2063

    130. Db01222

    131. Ks-1162

    132. Lp00174

    133. Nc00626

    134. Nsc 757788

    135. Sdccgsbi-0050162.p002

    136. 11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

    137. Budesonide Component Of Symbicort

    138. Ncgc00021318-05

    139. Ncgc00021318-06

    140. Ncgc00021318-08

    141. Ncgc00021318-18

    142. Ncgc00089747-04

    143. Ncgc00260859-01

    144. Bb164267

    145. Budesonide 100 Microg/ml In Acetonitrile

    146. Cpd000058337

    147. Hy-13580

    148. Pregna-1,4-diene-3,20-dione, 16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11-beta,16-alpha)-

    149. Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(r))-, And 16alpha,17-((s)-butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

    150. B3909

    151. Budesonide 100 Microg/ml In Methanol/water

    152. Eu-0100174

    153. D00246

    154. T70986

    155. 333b223

    156. Q422212

    157. J-504150

    158. Q-101375

    159. Sr-01000000101-2

    160. Sr-01000000101-6

    161. Brd-a34299591-001-03-4

    162. Budesonide, European Pharmacopoeia (ep) Reference Standard

    163. Budesonide, United States Pharmacopeia (usp) Reference Standard

    164. Budesonide, Pharmaceutical Secondary Standard; Certified Reference Material

    165. (11?,16?)-16,17-[butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

    166. (1s,2s,4r,8s,9s,11s,12s,13r)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

    167. (4ar,4bs,5s,6as,6bs,9ar,10as,10bs)-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2h-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

    168. (6ar,6bs,7s,8as,8bs,11ar,12as,12bs)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4h-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 430.5 g/mol
    Molecular Formula C25H34O6
    XLogP32.5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass430.23553880 g/mol
    Monoisotopic Mass430.23553880 g/mol
    Topological Polar Surface Area93.1 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity862
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 14  
    Drug NameBudesonide
    Drug LabelBudesonide, the active ingredient of ENTOCORT EC capsules, is a synthetic corticosteroid. It is designated chemically as (RS)-11, 16, 17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde. Budesonide is provided a...
    Active IngredientBudesonide
    Dosage FormSpray, metered; Capsule; Solution; Suspension
    RouteNasal; Inhalation; Topical foam; Oral
    Strength0.032mg/inh; 1mg/2ml; 0.5mg/2ml; 2mg; 3mg; 0.25mg/2ml
    Market StatusTentative Approval; Prescription
    CompanyWatson Labs; Barr Labs Div Teva; Teva Pharms; Apotex; Salix Pharms; Sandoz; Mylan

    2 of 14  
    Drug NameEntocort ec
    PubMed HealthBudesonide
    Drug ClassesAnti-Inflammatory, Endocrine-Metabolic Agent, Gastrointestinal Agent
    Drug LabelBudesonide, the active ingredient of ENTOCORT EC capsules, is a synthetic corticosteroid. It is designated chemically as (RS)-11, 16, 17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde. Budesonide is provided a...
    Active IngredientBudesonide
    Dosage FormCapsule
    RouteOral
    Strength3mg
    Market StatusPrescription
    CompanyAstrazeneca