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2 Chronic Hepatitis Delta SOLSTICE Trial Ahead of Schedule","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Vir Biotechnology","sponsor":"GSK","pharmaFlowCategory":"D","amount":"$345.0 million","upfrontCash":"$225.0 million","newsHeadline":"GSK, Vir End Flu Drug Alliance, Removing Key Piece of $345M Pact","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II"}]
Find Clinical Drug Pipeline Developments & Deals by Vir Biotechnology
VIR-3434 (tobevibart) is an investigational subcutaneously administered antibody designed to block entry of hepatitis B and hepatitis delta viruses into hepatocytes. It is being evaluated in combination with elebsiran for the treatment of chronic hepatitis D.
Under the termination, partners have ended their collaboration on anti-influenza antibodies, including VIR-2482, an investigational hemagglutinin targeting, intramuscularly administered influenza A-neutralizing monoclonal antibody.
The funding will be used to advance the development of novel monoclonal antibody (mAb) candidates, including VIR-7229, and delivery solutions to widen the applicability of mAbs in COVID-19 and in pandemic preparedness and response.
VIR-1388 is an investigational subcutaneously administered HIV T cell vaccine based on HCMV that has been designed to elicit abundant T cells that recognize HIV proteins in a way that differs from prior investigational HIV vaccines.
VIR-2482 is an investigational hemagglutinin targeting, intramuscularly administered influenza A-neutralizing monoclonal antibody. In vitro, it has been shown to cover all major strains of influenza A that have arisen since the 1918 flu pandemic.
Combinations of VIR-3434, VIR-2218, pegylated interferon alpha (PEG-IFNα) and a nucleoside reverse transcriptase inhibitor (NRTI) are being investigated in hepatitis B virus (HBV) immune-active, treatment-naïve adults.
The new grant will support its novel T cell vaccine platform phase 1 clinical development of VIR-1388, an investigational novel T cell vaccine for the prevention of human immunodeficiency virus (HIV). VIR-1388 is based on the human cytomegalovirus (HCMV) vector platform.
Xevudy (sotrovimab) is a mAb that treats mild-to-moderate COVID-19 by binding to and neutralizing the spike protein of SARS-CoV-2. It is also been designed to achieve high concentration in lungs to ensure optimal penetration into airway tissues affected by virus.
Vir retains the sole rights for advancing next-generation solutions for COVID-19 and other coronavirus outbreaks. The Companies will continue to collaborate on Xevudy (sotrovimab) and VIR-7832 and to develop new therapies for influenza and other respiratory diseases.
VIR-2482 is an investigational intramuscularly administered influenza A-neutralizing monoclonal antibody. In vitro, it has been shown to cover all major strains of influenza A that have arisen since the 1918 Spanish flu pandemic.
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