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Find Clinical Drug Pipeline Developments & Deals by Turning Point Therapeutics
Details :
TPX-0005 (repotrectinib) is an oral ROS1/TKI inhibitor in phase 1/2 development for locally advanced or metastatic ROS1-positive non-small cell lung cancer and NTRK-positive tumors.
Details :
TPX-0005 (repotrectinib), is a next-generation kinase inhibitor targeting the ROS1 and TRK oncogenic drivers of non-small cell lung cancer and advanced solid tumors.
Details :
Bristol Myers Squibb gains a pipeline of investigational medicines designed to target the most common mutations associated with oncogenesis, including TPX-0005 (repotrectinib).
Details :
TPX-0005 (repotrectinib) is small macrocyclic tyrosine kinase inhibitor of ROS1, TRK and ALK. Repotrectinib was designed to efficiently bind with the active kinase conformation and avoid steric interference from a variety of clinically resistant mutation...
Details :
TPX-4589 (LM-302) is a potentially first-in-class anti-Claudin18.2 ADC discovered by LaNova that suppresses cell proliferation of gastric and pancreatic cell lines with nanomolar potency in preclinical models. It also has demonstrated efficacy in gastric...
Details :
In TKI-naive patients for repotrectinib, in 71 total patients, there was a cORR of 79% across global trial. Ten of 11 patients responded within China for a cORR of 91% and DOR ranged from 3.6+ to 7.5+ months with a median duration of follow-up of 3.7 mon...
Details :
Enrollment target of 40 patients achieved for expansion cohort 6 (EXP-6) for TPX-0005 (repotrectinib), a next-generation kinase inhibitor targeting the ROS1 and TRK in NTRK-positive TKI-pretreated advanced solid tumors.
Details :
TPX-0131 has been shown preclinically to penetrate the central nervous system, which is important in the treatment of patients with ALK-positive non-small cell lung cancer as the disease often progresses in the brain.
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