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Oncology","highestDevelopmentStatusID":"7","companyTruncated":"Massachusetts General Hospital \/ Taiho Oncology"},{"orgOrder":0,"company":"Taiho Oncology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2014","type":"Inapplicable","leadProduct":"Trifluridine","moa":"DNA","graph1":"Oncology","graph2":"Phase I","graph3":"Taiho Oncology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Taiho Oncology \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Taiho Oncology \/ Undisclosed"},{"orgOrder":0,"company":"Taiho Oncology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2014","type":"Inapplicable","leadProduct":"Trifluridine","moa":"DNA","graph1":"Oncology","graph2":"Phase I","graph3":"Taiho Oncology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Taiho Oncology \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Taiho Oncology \/ Undisclosed"},{"orgOrder":0,"company":"Taiho Oncology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2014","type":"Inapplicable","leadProduct":"Trifluridine","moa":"DNA","graph1":"Oncology","graph2":"Approved FDF","graph3":"Taiho Oncology","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Taiho Oncology \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"Taiho Oncology \/ Undisclosed"},{"orgOrder":0,"company":"Rahul Parikh","sponsor":"Taiho Oncology","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cytotoxic Drug","year":"2018","type":"Inapplicable","leadProduct":"Trifluridine","moa":"DNA","graph1":"Oncology","graph2":"Phase II","graph3":"Rahul Parikh","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rahul Parikh \/ Taiho Oncology","highestDevelopmentStatusID":"8","companyTruncated":"Rahul Parikh \/ Taiho Oncology"},{"orgOrder":0,"company":"Patrick Joseph Loehrer Sr.","sponsor":"Indiana University | Taiho Oncology","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cytotoxic Drug","year":"2019","type":"Inapplicable","leadProduct":"Trifluridine","moa":"DNA","graph1":"Oncology","graph2":"Phase I","graph3":"Patrick Joseph Loehrer Sr.","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Patrick Joseph Loehrer Sr. \/ Indiana University | Taiho Oncology","highestDevelopmentStatusID":"6","companyTruncated":"Patrick Joseph Loehrer Sr. \/ Indiana University | Taiho Oncology"},{"orgOrder":0,"company":"Cancer Research","sponsor":"UCB Pharma S.A","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2023","type":"Collaboration","leadProduct":"Tipiracil HCl","moa":"||Gremlin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Cancer Research","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Cancer Research \/ UCB Pharma S.A","highestDevelopmentStatusID":"7","companyTruncated":"Cancer Research \/ UCB Pharma S.A"},{"orgOrder":0,"company":"XBiotech","sponsor":"The French National Cancer Institute","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2022","type":"Funding","leadProduct":"Tipiracil","moa":"||IL1A","graph1":"Oncology","graph2":"Phase III","graph3":"XBiotech","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"XBiotech \/ The French National Cancer Institute","highestDevelopmentStatusID":"10","companyTruncated":"XBiotech \/ The French National Cancer Institute"}]

Find Clinical Drug Pipeline Developments & Deals for Trifluridine

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                          Top Deals by Deal Size (USD bn)

                          01

                          GERCOR

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          GERCOR

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : Trifluridine is a Cytotoxic Drug drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          July 17, 2025

                          Lead Product(s) : Trifluridine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Servier

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Hepzato kit is a drug/device product which administers melphalan directly to the liver through the HDS, being investigated in combination with trifluridine-tipiracil for metastatic colorectal cancer.

                          Product Name : Hepzato

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : Melphalan Hydrochloride,Tipiracil Hydrochloride,Trifluridine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : PRO-140 (leronlimab) a monocloncal antibody works by blocking the activity of CCR5 receptor, being developed in combination with trifluridine plus tipiracil and bevacizumab for CCR5+, MSS mCRC.

                          Product Name : Vyrologix

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          August 12, 2024

                          Lead Product(s) : Leronlimab,Trifluridine,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          UNICANCER

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          UNICANCER

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : Trifluridine is a Cytotoxic Drug drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          February 07, 2024

                          Lead Product(s) : Trifluridine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Servier

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Lonsurf (trifluridine/tipiracil), an oral nucleoside antitumor agent, got approved as a single agent or in combination with bevacizumab for the treatment of adult patients with metastatic colorectal cancer (mCRC).

                          Product Name : Lonsurf

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          August 02, 2023

                          Lead Product(s) : Trifluridine,Bevacizumab,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Lonsurf consists of a thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, it has demonstrated anti-tumor activity against refractory colorectal cancer, in combination with bevacizumab.

                          Product Name : Lonsurf

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          April 18, 2023

                          Lead Product(s) : Trifluridine,Bevacizumab,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The collaboration focuses on the development of two antibody candidates, UCB6114 and UCB4594 by bringing together the oncology-focused translational research and clinical development capabilities of Cancer Research UK, and UCB’s renowned antibody disco...

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          March 09, 2023

                          Lead Product(s) : UCB6114,Trifluridine,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : UCB Pharma S.A

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Lonsurf is an oral nucleoside antitumor agent which consists trifluridine, and tipiracil (TP inhibitor), which increases trifluridine exposure by inhibiting its metabolism by TP. Trifluridine results in DNA dysfunction and inhibition of cell proliferatio...

                          Product Name : Lonsurf

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          January 17, 2023

                          Lead Product(s) : Trifluridine,Bevacizumab,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Taiho Oncology

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Lonsurf (trifluridine) and tipiracil consists of a thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase (TP) inhibitor, tipiracil, which increases trifluridine exposure by inhibiting its metabolism by TP.

                          Product Name : Lonsurf

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 12, 2022

                          Lead Product(s) : Trifluridine,Tipiracil HCl

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Taiho Oncology

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          UNICANCER

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          UNICANCER

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : Trifluridine is a Cytotoxic Drug drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Stomach Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          July 27, 2022

                          Lead Product(s) : Trifluridine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Servier

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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