

Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass.
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Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Rege Nephro
Deal Size : Undisclosed
Deal Type : Acquisition
Rege Nephro Acquires Tamibarotene Assets for U.S. Trials
Details : Through the acquisition, Rege Nephro will leverage RN-014 (tamibarotene) related clinical and non-clinical assets from Syros. It is being evaluated for autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Undisclosed
April 15, 2025
Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Rege Nephro
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Syros Announces Topline Data from Tamibarotene Phase 3 Trial
Details : SY-1425 (tamibarotene) is a first-in-class selective RARα agonist, being evaluated in combination with azacitidine for higher-risk myelodysplastic syndrome with RARA gene overexpression.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
November 12, 2024
Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : DCI Partners
Deal Size : $16.7 million
Deal Type : Series B Financing
Rege Nephro Completes Series B Funding For Kidney Disease Therapy Trials
Details : The funds will be used to advance the clinical trials of RN-014 (tamibarotene), company's retinoic acid receptor (RAR) agonist treatment, in Phase 2 for Autosomal Dominant Polycystic Kidney Disease.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Undisclosed
October 07, 2024
Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : DCI Partners
Deal Size : $16.7 million
Deal Type : Series B Financing

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Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Syros Provides Update on SELECT-AML-1 Phase 2 Clinical Trial
Details : Company will discontinue enrollment in clinical trial evaluating SY-1425 (tamibarotene) in combination with venetoclax and azacitidine in patients with AML and RARA gene overexpression.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
August 12, 2024
Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Rege Nephro Enrolls Patients For Phase II Tamibarotene ADPKD Trial
Details : RN-014 (tamibarotene), under development for ADPKD, is a retinoic acid receptor (RAR) agonist expected to potently inhibit cyst formation and improve renal function.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
May 28, 2024
Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Syros Completes Enrollment Of 190 Patients for SELECT-MDS-1 Phase 3 Trial
Details : SY-1425 (tamibarotene) is a selective RARα agonist being evaluated with azacitidine for newly diagnosed HR-MDS patients with RARA gene overexpression.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
March 25, 2024
Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Study of Tamibarotene in Patients With ADPKD
Details : Tamibarotene is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Polycystic Kidney, Autosomal Dominant.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
March 04, 2024
Lead Product(s) : Tamibarotene
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : TD Cowen
Deal Size : $45.0 million
Deal Type : Public Offering
Details : The net proceeds will be used to fund the ongoing clinical development of SY-1425 (tamibarotene), a first-in-class selective retinoic acid receptor alpha (RARα) agonist, being developed for myelodysplastic syndromes.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Undisclosed
December 19, 2023
Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : TD Cowen
Deal Size : $45.0 million
Deal Type : Public Offering

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Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SELECT-AML-1 is evaluating the safety and efficacy of SY-1425 (tamibarotene) in combination with venetoclax and azacitidine compared to venetoclax and azacitidine in patients patients with acute myeloid leukemia and RARA gene overexpression.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
December 06, 2023
Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SY-1425 (tamibarotene), an oral first-inclass selective retinoic acid receptor alpha (RARα) agonist, is currently being evaluated in combination with azacitidine for the treatment of newly diagnosed HR-MDS patients with RARA gene overexpression.
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
January 26, 2023
Lead Product(s) : Tamibarotene,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
