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    [{"orgOrder":0,"company":"Spark Therapeutics, Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"SPK-8011","moa":"Coagulation factor VIII (F8)","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Spark Therapeutics, Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Spark Therapeutics, Inc \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Spark Therapeutics, Inc \/ Inapplicable"},{"orgOrder":0,"company":"Spark Therapeutics, Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"SPK-8011","moa":"Coagulation factor VIII (F8)","graph1":"Genetic 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(F8)","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Spark Therapeutics, Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Spark Therapeutics, Inc \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Spark Therapeutics, Inc \/ Inapplicable"},{"orgOrder":0,"company":"Spark Therapeutics, Inc","sponsor":"SpliceBio","pharmaFlowCategory":"D","therapeuticArea":"Rare Diseases and Disorders","country":"SPAIN","productType":"Undisclosed","year":"2023","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Rare Diseases and Disorders","graph2":"Discovery","graph3":"Spark Therapeutics, Inc","amount2":0.22,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Rare Diseases","amount2New":0.22,"dosageForm":"Intravitreal Injection","sponsorNew":"Spark Therapeutics, Inc \/ Spark Therapeutics, 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Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spark Therapeutics, Inc \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Spark Therapeutics, Inc \/ Inapplicable"},{"orgOrder":0,"company":"Spark Therapeutics, Inc","sponsor":"CombiGene","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Licensing Agreement","leadProduct":"CG01","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Spark Therapeutics, Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spark Therapeutics, Inc \/ CombiGene","highestDevelopmentStatusID":"4","companyTruncated":"Spark Therapeutics, Inc \/ CombiGene"}]

    Find Clinical Drug Pipeline Developments & Deals by Spark Therapeutics, Inc

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                            01

                            Spark Therapeutics, Inc

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                            Spark Therapeutics, Inc

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                            Lead Product(s) : SPK-10001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 14, 2025

                            Lead Product(s) : SPK-10001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
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                            Spark Therapeutics, Inc

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                            CPHI Shenzhen
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                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of a Gene Therapy Treatment for Hemophilia A

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 07, 2024

                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
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                            Spark Therapeutics, Inc

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                            CPHI Shenzhen
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Discovery

                            Recipient : SpliceBio

                            Deal Size : $216.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SpliceBio Enters Collaboration with Spark Therapeutics to Develop a Gene Therapy Targeting an Inherited Retina...

                            Details : Under the agreement, Spark secures exclusive worldwide rights to SpliceBio's proprietary Protein Splicing platform to develop, manufacture, and commercialize a gene therapy targeting an undisclosed inherited retinal disease.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            October 17, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Discovery

                            Recipient : SpliceBio

                            Deal Size : $216.0 million

                            Deal Type : Licensing Agreement

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                            04

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : Discovery

                            Sponsor : Neurochase

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Spark Therapeutics Enters Into Strategic Collaboration with Neurochase for Use of Proprietary Delivery Technol...

                            Details : Neurochase is developing a proprietary drug delivery system and Spark will develop selected gene therapies for CNS disorders using the Neurochase technology, which aims to improve targeted delivery of AAV gene therapy to neural structures using the metho...

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            January 27, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Discovery

                            Sponsor : Neurochase

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spark Therapeutics Announces Updated Phase 1/2 Study Results Supporting the Durability of Investigational Gene...

                            Details : SPK-8011, a novel bio-engineered adeno-associated viral (AAV) vector utilizing the AAV-LK03 capsid, also referred to as Spark200, contains a codon-optimized human factor VIII gene under the control of a liver-specific promoter.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 12, 2022

                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
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                            Spark Therapeutics, Inc

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                            Lead Product(s) : CG01

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : CombiGene

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Spark Therapeutics and CombiGene Enter into Exclusive, Global Licensing Agreement for Gene Therapy Candidate C...

                            Details : The agreement provides Spark with the exclusive, worldwide license to develop, manufacture and commercialize CG01. CombiGene will continue to execute certain aspects of the preclinical program in collaboration with Spark.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            December 10, 2021

                            Lead Product(s) : CG01

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : CombiGene

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
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                            Spark Therapeutics, Inc

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                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spark Therapeutics Updated SPK-8011 Data from Phase 1/2 Study Shows Multi-Year, Durable Factor VIII (FVIII) Ex...

                            Details : SPK-8011, a novel bio-engineered adeno-associated viral (AAV) vector utilizing the AAV-LK03 capsid, contains a codon-optimized human factor VIII gene under the control of a liver-specific promoter.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 17, 2021

                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
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                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spark Therapeutics’ SPK-8011 Suggests Stable and Durable Factor VIII Expression in Largest Phase 1/2 Gene Th...

                            Details : Investigational SPK-8011, a novel bio-engineered adeno-associated viral (AAV) vector utilizing the AAV-LK03 capsid, also referred to as Spark200, contains a codon-optimized human factor VIII gene under the control of a liver-specific promoter.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 21, 2021

                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Recipient : NeuExcell therapeutics

                            Deal Size : $190.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            NeuExcell Therapeutics and Spark Therapeutics Announce Research Collaboration Agreement to Develop a Novel Gen...

                            Details : Under the terms of the agreement, Spark Therapeutics will receive access to NeuExcell's proprietary neuro-regenerative gene therapy platform and capabilities.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            July 09, 2021

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Recipient : NeuExcell therapeutics

                            Deal Size : $190.0 million

                            Deal Type : Collaboration

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                            10

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed

                            Spark Therapeutics, Inc

                            U.S.A arrow
                            CPHI Shenzhen
                            Not Confirmed
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                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spark Therapeutics Announces Updated Data on SPK-8011 from Phase 1/2 Clinical Trial in Hemophilia A at ISTH 20...

                            Details : All five patients in the 5x1011 vg/kg and 1×1012 vg/kg dose cohorts and seven participants in the 2×1012 vg/kg dose show an acceptable safety profile, stable & durable factor VIII expression and substantial improvement in annualized bleed rate after tr...

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 07, 2020

                            Lead Product(s) : SPK-8011

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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