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    [{"orgOrder":0,"company":"Sirona Biochem Corp","sponsor":"International Centre for Genetic Engineering and Biotechnology","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Other Small Molecule","year":"2022","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Sirona Biochem Corp","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Buccal","sponsorNew":"Sirona Biochem Corp \/ International Centre for Genetic Engineering and Biotechnology","highestDevelopmentStatusID":"4","companyTruncated":"Sirona Biochem Corp \/ International Centre for Genetic Engineering and Biotechnology"},{"orgOrder":0,"company":"Sirona Biochem Corp","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious 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Inapplicable"},{"orgOrder":0,"company":"Sirona Biochem Corp","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"CANADA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"TFC-1326","moa":"Undisclosed","graph1":"Dermatology","graph2":"Phase I","graph3":"Sirona Biochem Corp","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Cream","sponsorNew":"Sirona Biochem Corp \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Sirona Biochem Corp \/ Inapplicable"},{"orgOrder":0,"company":"Sirona Biochem Corp","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"CANADA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"TFC-1326","moa":"Undisclosed","graph1":"Dermatology","graph2":"Phase I","graph3":"Sirona Biochem 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GmbH","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"CANADA","productType":"Other Small Molecule","year":"2025","type":"Private Placement","leadProduct":"Difluorocyclohexyloxyphenol","moa":"Human tyrosinase","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Sirona Biochem Corp","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Cream","sponsorNew":"Sirona Biochem Corp \/ Promura GmbH","highestDevelopmentStatusID":"1","companyTruncated":"Sirona Biochem Corp \/ Promura GmbH"}]

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                            01

                            Sirona Biochem Corp

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                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Study Phase : Undisclosed

                            Sponsor : Promura GmbH

                            Deal Size : $2.1 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Sirona Inks Strategic Investment And JV Deal with Promura GmbH

                            Details : The proceeds will be used to advance the ongoing research and development of TFC-1067 for the treatment of dyschromia.

                            Product Name : TFC-1067

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            April 22, 2025

                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Highest Development Status : Undisclosed

                            Sponsor : Promura GmbH

                            Deal Size : $2.1 million

                            Deal Type : Private Placement

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                            02

                            Sirona Biochem Corp

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                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sirona Biochem Initiates GlycoProteMim Trademark for Anti-Aging Molecule TFC-1326

                            Details : GlycoProteMim (TFC-1326) is Sirona’s lead anti-aging compound, a topical cream small molecule drug candidate, with potential to reverse the effects of aging on facial skin, restoring lost volume and reducing fine wrinkles.

                            Product Name : TFC-1326

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 12, 2023

                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Sirona Biochem Corp

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                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sirona Biochem Announces Exceptional Clinical Trial Results for Anti-Aging Compound TFC-1326

                            Details : TFC-1326 is Sirona’s lead anti-aging compound, will soon enter a clinical trial designed to assess its potential to reverse the effects of aging on facial skin, restoring lost volume and reducing fine wrinkles.

                            Product Name : TFC-1326

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 25, 2023

                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Sirona Biochem Corp

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sirona Biochem Receives Antiviral Testing Results

                            Details : The ICGEB has successfully screened a library of 20 compounds produced at Sirona’s subsidiary TFChem as potential inhibitors of SARS-CoV-2 using specialized assays developed at the centre.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 27, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Sirona Biochem Corp

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                            Lead Product(s) : TFC-039

                            Therapeutic Area : Endocrinology

                            Study Phase : Preclinical

                            Sponsor : Wanbang Biopharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Sirona Biochem Signs International Partnership Agreement with Wanbang Biopharmaceuticals

                            Details : Under the agreement, Wanbang obtained the rights to develop the SGLT2 inhibitor, TFC-039 as a diabetes treatment in China and Sirona retained the global rights. SGLT2 inhibitors provide an opportunity to treat inflicted animals with an oral medication.

                            Product Name : TFC-039

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            November 23, 2022

                            Lead Product(s) : TFC-039

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Preclinical

                            Sponsor : Wanbang Biopharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            06

                            Sirona Biochem Corp

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                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sirona Biochem Reports Positive Results in Safety Study for Anti-Aging Compound TFC-1326

                            Details : TFC-1326 1% in formulation is a non-irritant and non-sensitizer, a claim recognized in the industry based on these results and accepted by global regulatory bodies.

                            Product Name : TFC-1326

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 16, 2022

                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Sirona Biochem Corp

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Discovery

                            Sponsor : International Centre for Genetic Engineering and Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Sirona Biochem Signs Research Collaboration Agreement with International Centre for Genetic Engineering and Bi...

                            Details : Scientists at ICGEB will test the potential antivirals against SARS-CoV-2 (COVID-19) using specialized assays developed at the centre.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            October 11, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Discovery

                            Sponsor : International Centre for Genetic Engineering and Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            08

                            Sirona Biochem Corp

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                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sirona Biochem Announces Start of Clinical Trial for Anti-Aging Compound TFC-1326

                            Details : The formulation is a cream base with TFC-1326 at a concentration of 1% and no other active ingredients. The trial is designed to assess the compound’s efficacy in reversing aging facial skin, including restoring lost volume (plumping) and reducing fine...

                            Product Name : TFC-1326

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 12, 2022

                            Lead Product(s) : TFC-1326

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Sirona Biochem Corp

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                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Study Phase : Undisclosed

                            Sponsor : Allergan Aesthetics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Sirona Biochem Announces Exclusive Global Licensing Agreement with Allergan Aesthetics

                            Details : Under Licensing agreement with Sirona, pursuant to which Allergan Aesthetics will develop and commercialize topical skin care treatments based on active ingredients derived from certain of Sirona’s patents for TFC-1067 (Difluorocyclohexyloxyphenol) and...

                            Product Name : TFC-1067

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 13, 2022

                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Highest Development Status : Undisclosed

                            Sponsor : Allergan Aesthetics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            10

                            Sirona Biochem Corp

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                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Study Phase : Undisclosed

                            Sponsor : RODAN & FIELDS LLC

                            Deal Size : Undisclosed

                            Deal Type : Termination

                            DEALS_DEV arrow-down

                            Sirona Biochem Announces the Termination of Supply Agreement with Rodan + Fields

                            Details : Under the terms of the agreement, Sirona will manufacture and supply TFC-1067 (difluorocyclohexyloxyphenol), a novel, new skin brightening ingredient, for use by Rodan + Fields on a non-exclusive basis and Rodan + Fields will launch a new product incorpo...

                            Product Name : TFC-1067

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 16, 2022

                            Lead Product(s) : Difluorocyclohexyloxyphenol

                            Therapeutic Area : Dermatology

                            Highest Development Status : Undisclosed

                            Sponsor : RODAN & FIELDS LLC

                            Deal Size : Undisclosed

                            Deal Type : Termination

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