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                          Top Deals by Deal Size (USD bn)

                          01

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : The net proceeds will support the development of the Cartesian pipeline through the Phase 3 study of lead product candidate, Descartes-08, a potential first-in-class RNA-engineered chimeric antigen receptor T-cell therapy (rCAR-T) for the treatment of my...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          November 13, 2023

                          Lead Product(s) : Descartes-08

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Cartesian Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : The combined company will focus on the development of the Cartesian pipeline through the Phase 3 study of lead product candidate, Descartes-08, a potential first-in-class RNA-engineered chimeric antigen receptor T-cell therapy (rCAR-T) for the treatment ...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          November 13, 2023

                          Lead Product(s) : Descartes-08

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Leerink Partners

                          Deal Size : $60.2 million

                          Deal Type : Private Placement

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                          03

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Sobi will transition the manufacturing and development rights of ImmTOR for SEL-212 to Sobi. SEL-212, a combination of Selecta’s ImmTOR immune tolerance platform and a therapeutic uricase enzyme (pegadricase), is in development for chronic refractory g...

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : $75.0 million

                          October 31, 2023

                          Lead Product(s) : Pegadricase,ImmTOR

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase III

                          Sponsor : Swedish Orphan Biovitrum AB

                          Deal Size : $705.0 million

                          Deal Type : Licensing Agreement

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                          04

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : SEL-018 (xork) is being studied as a potential next generation immunoglobulin G (IgG) protease that will be developed by Astellas for use with AT845, an investigational, adeno-associated virus (AAV)-based treatment for Late-Onset Pompe disease (LOPD) in ...

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : $10.0 million

                          September 01, 2023

                          Lead Product(s) : Xork,AT845

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Astellas Pharma

                          Deal Size : $350.0 million

                          Deal Type : Licensing Agreement

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                          05

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : SEL-212 (combination of ImmTOR immune tolerance platform and pegadricase) is designed to reduce serum urate levels in people with chronic refractory gout, potentially reducing harmful tissue urate deposits which causes debilitating gout flares and joint ...

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          March 21, 2023

                          Lead Product(s) : Pegadricase,SEL-110

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 21, 2023

                          Lead Product(s) : SEL-302

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : National Human Genome Research Institute

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : The selection of a next generation Immunoglobulin A (IgA) protease from IGAN Biosciences for its IgA nephropathy (IgAN) program, will lead Selecta Biosciences to pay IGAN Biosciences.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          December 14, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Nephrology

                          Highest Development Status : Preclinical

                          Recipient : IGAN Biosciences

                          Deal Size : $1.6 million

                          Deal Type : Licensing Agreement

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                          08

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : SEL-302 is Adeno-Associated Virus (AAV) sterotype which consists of MMA-101 plus ImmTOR for the treatment of patients with methylmalonic acidemia (MMA).

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          November 10, 2022

                          Lead Product(s) : SEL-302

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : SEL-302 comprises ImmTOR in combination with MMA-101, and has the potential to mitigate unwanted immunogenicity to treat individuals with methylmalonic acidemia.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 05, 2022

                          Lead Product(s) : SEL-302

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : The partnership leverages Genovis’ proprietary immunoglobulin G protease, IdeXork, and Selecta’s ImmTOR platform to enable the dosing of transformative gene therapies in patients with pre-existing adeno-associated virus immunity and treat IgG-mediate...

                          Product Name : IdeXork

                          Product Type : Enzyme

                          Upfront Cash : Undisclosed

                          October 21, 2021

                          Lead Product(s) : Immunoglobulin G Protease

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Genovis

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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