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    [{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Cryostem","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"FRANCE","productType":"Miscellaneous","year":"2021","type":"Collaboration","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Rheos Medicines","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Rheos Medicines"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"RHX-317","moa":"MALT1","graph1":"Immunology","graph2":"IND Enabling","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Rheos Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rheos Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rheos Medicines","sponsor":"Medivir","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWEDEN","productType":"Undisclosed","year":"2021","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Rheos Medicines","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rheos Medicines \/ Rheos Medicines","highestDevelopmentStatusID":"4","companyTruncated":"Rheos Medicines \/ Rheos Medicines"}]

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                            01

                            Rheos Medicines

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rheos Medicines Receives FDA “Study May Proceed” Letter to Initiate Phase 1 Clinical Study Under its Inves...

                            Details : A MALT1 inhibitor, RHX-317 is designed to inhibit the activity of multiple immune cell types, attenuating the inflammatory response in the activated immune system, for the treatment of autoimmune and inflammatory diseases.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 20, 2022

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rheos Medicines Announces Publication of New Data to Support Targeting MALT1 to Treat Autoimmune and Inflammat...

                            Details : RHX-317 targets MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), a protein expressed exclusively in cells of immune system, designed to inhibit activity of multiple immune cell types, attenuating the inflammatory response in ac...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 09, 2022

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Rheos Medicines

                            U.S.A arrow
                            AIChE Annual Meeting
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                            AIChE Annual Meeting
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rheos Medicines Presents New Data Supporting MALT1 Inhibition as Novel Strategy for Precision Medicine-Based A...

                            Details : RHX-317, is a novel, small molecule MALT1 inhibitor initially in development for the treatment of chronic GVHD. Preclinical data demonstrate MALT1 inhibition targets pathogenic activity of the activated immune system, showing efficacy in a model of cGVHD...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 13, 2021

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rheos Medicines to Present Data at ASH 2021 for MALT1 Inhibition for Treatment of Graft-Versus-Host Disease

                            Details : Rheos Medicines will present preclinical data showing the potential of RHX-317, a MALT1 inhibitors for the treatment of chronic Graft-Versus-Host Disease (GVHD) at the 63rd Annual Meeting of the American Society of Hematology.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 04, 2021

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Rheos Medicines

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rheos Medicines Presents Data Demonstrating Potential of MALT1 Inhibition as Novel Approach for the Treatment ...

                            Details : The results demonstrating MALT1 inhibition support Rheos’s lead product candidate, RHX-317, a novel, small molecule MALT1 inhibitor, that the company is initially developing for the treatment of chronic graft versus host disease (GVHD).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 01, 2021

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Study Phase : IND Enabling

                            Recipient : Cryostem

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Rheos Medicines Forms Research Collaboration With CRYOSTEM to Evaluate MALT1‑Targeted Therapeutics for Graft...

                            Details : The goal of the collaboration is to provide biological resources from HSC patients in order to evaluate MALT1-targeted therapeutics, including Rheos’s lead product candidate, RHX-317, for Graft-versus-Host Disease, based on functional immunologic profi...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 27, 2021

                            Lead Product(s) : RHX-317

                            Therapeutic Area : Immunology

                            Highest Development Status : IND Enabling

                            Recipient : Cryostem

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Rheos Medicines

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Rheos Medicines

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                            AIChE Annual Meeting
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Recipient : Medivir

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Joint Patent Application For MALT1 Inhibitors Published

                            Details : The patent application is an outcome of the option agreement that was previously entered into between the two companies regarding Medivir’s preclinical MALT1 project.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            October 15, 2021

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Recipient : Medivir

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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