
													
															
															Year
															DEALS // DEV.
															Country
															
															Therapeutic Area
															Study Phase
															Deal Type
															Product Type
															Dosage Form
															Lead Product
															Target

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Scribe Therapeutics
Deal Size : $1575.0 million
Deal Type : Collaboration
Scribe Hits Milestone with Prevail, Will Present AAV Tech at ASGCT
Details : Scribe and Prevail’s collaboration will advance in vivo therapeutics for neurological and neuromuscular diseases using Scribe’s CRISPR technology.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $75.0 million
April 28, 2025
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Scribe Therapeutics
Deal Size : $1575.0 million
Deal Type : Collaboration

A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
Details : LY3962681 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Parkinson Disease.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
August 21, 2024

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Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Recipient : Precision BioSciences
Deal Size : $555.0 million
Deal Type : Termination
Precision BioSciences Announces Return of Programs and End of Collaboration with Prevail
Details : Precision exercised its option to regain rights for the programs, including its novel proprietary ARCUS® platform to develop in vivo gene editing therapies for sophisticated gene edits.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $100.0 million
April 16, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Recipient : Precision BioSciences
Deal Size : $555.0 million
Deal Type : Termination

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Sangamo Therapeutics
Deal Size : $1,190.0 million
Deal Type : Agreement
Details : Under the agreement, Prevail has been granted rights to evaluate certain proprietary adeno-associated virus (AAV) capsids developed by Sangamo and may exercise certain options to license these capsids for multiple undisclosed neurological targets.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
July 17, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Sangamo Therapeutics
Deal Size : $1,190.0 million
Deal Type : Agreement

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Scribe Therapeutics
Deal Size : $1,575.0 million
Deal Type : Collaboration
Details : Under the collaboration, Prevail gets exclusive rights to Scribe’s CRISPR X-Editing (XE) technologies for the development of in vivo therapies directed to specified genetic targets known to cause serious neurological and neuromuscular diseases.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $75.0 million
May 16, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Scribe Therapeutics
Deal Size : $1,575.0 million
Deal Type : Collaboration

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Capsida
Deal Size : $740.0 million
Deal Type : Collaboration
Details : Delivering AAV gene therapy systemically to target the CNS, while limiting exposure to non-target organs (such as the liver), has been a significant challenge in the gene therapy field.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $55.0 million
January 04, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Capsida
Deal Size : $740.0 million
Deal Type : Collaboration

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Discovery
Recipient : Lacerta Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The collaboration will focus on the discovery and development of novel AAV capsids for CNS diseases. As a part of the collaboration, Prevail will receive rights to utilize one of Lacerta’s novel AAV capsids for select undisclosed CNS targets.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
August 23, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Discovery
Recipient : Lacerta Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : LY3884961
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : LY3884961 is a drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Gaucher Disease.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
August 04, 2022
Lead Product(s) : LY3884961
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PR001,Methylprednisolone,Sirolimus
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : $1,040.0 million
Deal Type : Acquisition
Lilly Completes Acquisition of Prevail Therapeutics
Details : Acquisition will set up a gene therapy program at Lilly, based on Prevail's portfolio of neuroscience assets, including the lead candidate, PR001, and will broaden Lilly's commitment to use novel modalities to address fatal genetic forms of neurodegenera...
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
January 22, 2021
Lead Product(s) : PR001,Methylprednisolone,Sirolimus
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : $1,040.0 million
Deal Type : Acquisition

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Lead Product(s) : PR001,Methylprednisolone,Sirolimus
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : $1,040.0 million
Deal Type : Acquisition
Lilly Announces Agreement to Acquire Prevail Therapeutics
Details : Acquisition will establish a gene therapy program at Lilly, anchored by Prevail's portfolio of neuroscience assets, and will broaden Lilly's commitment to use novel modalities to attempt to address otherwise fatal genetic forms of neurodegenerative disea...
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
December 15, 2020
Lead Product(s) : PR001,Methylprednisolone,Sirolimus
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Eli Lilly
Deal Size : $1,040.0 million
Deal Type : Acquisition
