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Find Clinical Drug Pipeline Developments & Deals by Peptilogics
PLG0206 is an investigational broad-spectrum, anti-bacterial and anti-biofilm peptide therapeutic currently in clinical development for the treatment of Periprosthetic Joint Infection.
PLG0206 is an investigational, broad-spectrum, anti-biofilm, anti-infective peptide, best-in-class, rapid bactericidal therapeutic currently in clinical development for the treatment of periprosthetic joint infection (PJI).
Results demonstrate that PLG0206 was active against all tested isolates and retained activity against multi-drug resistant (MDR) strains, suggesting that the unique mechanism of action of PLG0206 can overcome the drug-resistance mechanisms found in these MDR strains.
PLG0206 is an investigational, broad-spectrum, non-traditional antibiotic peptide therapeutic for the treatment of PJI. PLG0206 has the potential to rapidly target bacteria and persistent pathogens that produce biofilm and evade conventional antibiotics.
PLG0206 was designed with a unique mechanism of action that allows it to directly address persistent bacterial pathogens within the biofilm that evade standard-of-care antibiotics by targeting and disrupting bacterial membranes to trigger bacterial cell death.
Peptilogics’ Nautilus™ platform enables in silico predictive peptide design across diverse targets to efficiently access new functional chemical space and custom design therapeutics.
Poster and oral presentation of PLG0206 showcase broad-spectrum activity against drug-resistant bacteria and its ability to prevent spontaneous mutant growth with a variety of pathogens that cause periprosthetic joint infections (PJI).
PLG0206, is a novel peptide therapy granted orphan drug designation, initially targeted for prosthetic joint infections, an orthopedics indication is best-in-class, broad-spectrum potency targets multi-drug-resistant bacteria with improved resistance profiles.
The award provided by the Cystic Fibrosis Foundation will generate both in vitro and in vivo data about PLG0301 and PLG0206, which may potentially support an Investigational New Drug (IND) application with the FDA for its continued development.
The proceeds of the financing will be used to expand Peptilogics’ computational platform and invest in technologies to improve its drug design engine, as well as accelerate development of a pipeline of peptide therapeutics including the Company’s lead clinical asset, PLG0206.
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