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    [{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"IRELAND","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Pegloticase","moa":"Uric acid oxidative enzyme","graph1":"Rheumatology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Amgen Inc \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Amgen Inc \/ Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"IRELAND","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Pegloticase","moa":"Uric acid oxidative enzyme","graph1":"Rheumatology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved 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Michigan","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"IRELAND","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Pegloticase","moa":"||Uric acid oxidative enzyme","graph1":"Rheumatology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Amgen Inc \/ University of Michigan","highestDevelopmentStatusID":"15","companyTruncated":"Amgen Inc \/ University of Michigan"},{"orgOrder":0,"company":"ProtoKinetix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Pegloticase","moa":"Uric acid oxidative enzyme","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"ProtoKinetix","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ProtoKinetix \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"ProtoKinetix \/ Inapplicable"}]

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                            01

                            Amgen Inc

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            DEALS_DEV arrow-down

                            Horizon Therapeutics plc Submits Supplemental Biologics License for the Concomitant Use of KRYSTEXXA® (peglot...

                            Details : sBLA Submission based on recent results from the MIRROR randomized clinical trial, which showed a 71% response rate for patients randomized to receive KRYSTEXXA (Pegloticase) PEGylated uric acid specific enzyme, plus methotrexate for people living with u...

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 01, 2022

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Sustained Patient Response to KRYSTEXXA® (pegloticase) Injection with Methotrexate Compared to KRYSTEXXA Alon...

                            Details : The co-administration of KRYSTEXXA (pegloticase) with an immunomodulator like methotrexate has increasingly been employed in patients with uncontrolled gout to help reduce the development of antidrug antibodies, which can affect treatment efficacy with b...

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            August 11, 2022

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Horizon Therapeutics plc Announces FDA Has Granted Priority Review of the Supplemental Biologics License Appli...

                            Details : Application based on recent MIRROR randomized controlled trial results, which showed 71% of patients randomized to receive KRYSTEXXA (pegloticase), a PEGylated uric acid specific enzyme plus methotrexate achieved a complete response.

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            July 03, 2022

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Horizon Therapeutics plc to Present MIRROR Randomized Controlled Trial Primary Endpoint Data at The EULAR 2022...

                            Details : KRYSTEXXA® (pegloticase injection) is a PEGylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy.

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 24, 2022

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

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                            05

                            Amgen Inc

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Data Presented from the MIRROR Randomized Controlled Trial Demonstrate KRYSTEXXA® (pegloticase injection) Plu...

                            Details : The MIRROR randomized controlled trial outcomes provided a clear view of improvements in patient response and reductions in infusion reactions for KRYSTEXXA plus low-dose (15 mg/week) methotrexate compared to KRYSTEXXA plus placebo.

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            January 06, 2022

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            Amgen Inc

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Horizon Therapeutics Provides Update on TEPEZZA® (teprotumumab-trbw) Supply and New KRYSTEXXA® (pegloticase ...

                            Details : The Company announced two new KRYSTEXXA development programs: KRYSTEXXA, with methotrexate monthly dosing trial and a KRYSTEXXA retreatment trial evaluating KRYSTEXXA, with methotrexate, in patients who have previously failed KRYSTEXXA.

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 01, 2021

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            07

                            Amgen Inc

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                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            MIRROR Randomized Controlled Trial Meets Primary Endpoint and Shows 71% of Patients Achieved a Complete Respon...

                            Details : Results show that 71% (71 of 100) of patients who were randomized to receive KRYSTEXXA with methotrexate compared to 40% (21 of 52) of patients who were randomized to receive KRYSTEXXA with placebo achieved the primary endpoint (p<0.001).

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 25, 2021

                            Lead Product(s) : Pegloticase,Methotrexate

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            08

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                            Lead Product(s) : Pegloticase,Mycophenolate Mofetil

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase IV

                            Sponsor : University of Michigan

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Data Published in Arthritis & Rheumatology Show Higher Response Rates of Horizon's KRYSTEXXA with the Immunomo...

                            Details : The Reducing Immunogenicity of Pegloticase trial showed that 86% of patients receiving co-therapy of KRYSTEXXA with the immunomodulator mycophenolate mofetil achieved serum uric acid (sUA) ≤ 6 mg/dL at 12 weeks vs 40% of patients (4 of 10) receiving KR...

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            July 04, 2021

                            Lead Product(s) : Pegloticase,Mycophenolate Mofetil

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase IV

                            Sponsor : University of Michigan

                            Deal Size : Inapplicable

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                            09

                            ProtoKinetix

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                            Lead Product(s) : Pegloticase

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Peer Reviewed Research Paper Reports that ProtoKinetix's AAGP® Enhanced Stem Cell Vision Restoration

                            Details : PKTX-001 has shown to significantly improve cell survival and integration into host tissue and will be a valuable asset in the field of regenerative medicine in the future.

                            Product Name : PKTX-001

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            July 04, 2021

                            Lead Product(s) : Pegloticase

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

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                            Lead Product(s) : Pegloticase

                            Therapeutic Area : Rheumatology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Horizon Therapeutics plc Highlights Expanding R&D Efforts with Data Presentations at the EULAR European Congre...

                            Details : PROTECT trial evaluating the use of KRYSTEXXA (pegloticase injection) in people with chronic gout refractory to conventional therapies who have received a kidney transplant, as well as pharmacokinetic data regarding the concomitant use of KRYSTEXXA and m...

                            Product Name : Krystexxa

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 21, 2021

                            Lead Product(s) : Pegloticase

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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