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    [{"orgOrder":0,"company":"AgomAb Therapeutics N.V","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"BELGIUM","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"AGMB-129","moa":"ALK-5 receptor","graph1":"Immunology","graph2":"Phase II","graph3":"AgomAb Therapeutics N.V","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"AgomAb Therapeutics N.V \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"AgomAb Therapeutics N.V \/ Undisclosed"},{"orgOrder":0,"company":"AgomAb Therapeutics N.V","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"BELGIUM","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"AGMB-129","moa":"ALK-5 receptor","graph1":"Undisclosed","graph2":"Phase I","graph3":"AgomAb Therapeutics 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N.V","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"BELGIUM","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"AGMB-129","moa":"ALK-5 receptor","graph1":"Immunology","graph2":"Phase II","graph3":"AgomAb Therapeutics N.V","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"AgomAb Therapeutics N.V \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"AgomAb Therapeutics N.V \/ Undisclosed"},{"orgOrder":0,"company":"Origo Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"SPAIN","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"ORG-129","moa":"TGF-beta","graph1":"Undisclosed","graph2":"Phase I","graph3":"Origo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Origo Biopharma \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Origo Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"Origo Biopharma","sponsor":"AgomAb Therapeutics N.V","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"SPAIN","productType":"Miscellaneous","year":"2021","type":"Acquisition","leadProduct":"ORG-129","moa":"TGF-beta","graph1":"Immunology","graph2":"Phase I","graph3":"Origo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Origo Biopharma \/ AgomAb Therapeutics N.V","highestDevelopmentStatusID":"6","companyTruncated":"Origo Biopharma \/ AgomAb Therapeutics N.V"},{"orgOrder":0,"company":"AgomAb Therapeutics N.V","sponsor":"JPMorgan Chase | Morgan Stanley | Leerink Partners","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"BELGIUM","productType":"Miscellaneous","year":"2026","type":"Public Offering","leadProduct":"Ontunisertib","moa":"ALK5","graph1":"Immunology","graph2":"Phase II","graph3":"AgomAb Therapeutics N.V","amount2":0.10000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0.10000000000000001,"dosageForm":"Capsule","sponsorNew":"AgomAb Therapeutics N.V \/ JPMorgan Chase | Morgan Stanley | Leerink Partners","highestDevelopmentStatusID":"8","companyTruncated":"AgomAb Therapeutics N.V \/ JPMorgan Chase | Morgan Stanley | Leerink Partners"}]

    Find Clinical Drug Pipeline Developments & Deals for Ontunisertib

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                            01

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : JPMorgan Chase | Morgan Stanley | Leerink Partners

                            Deal Size : $100.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Agomab and SpyGlass Plan IPOs in Immunology and Eye Care

                            Details : In a public offering, Ontunisertib, a miscellaneous product targeting ALK5, aims to address Fibrostenotic Crohn's Disease.

                            Product Name : AGMB-129

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            January 19, 2026

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : JPMorgan Chase | Morgan Stanley | Leerink Partners

                            Deal Size : $100.0 million

                            Deal Type : Public Offering

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                            02

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Multiple Ascending Dose Study with AGMB-129 in Healthy Participants

                            Details : AGMB-129 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Crohn Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 12, 2025

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Agomab Reports Positive Phase 2a Results for AGMB-129 in Crohn’s Disease

                            Details : AGMB-129 is an oral gastro-intestinal (GI)-restricted small molecule inhibitor of ALK5 (TGF-β RI or ALK5), being studied for the potential treatment of Fibrostenosing Crohn’s Disease (FSCD).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 10, 2025

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Sanofi

                            Deal Size : $89.0 million

                            Deal Type : Series D Financing

                            DEALS_DEV arrow-down

                            Agomab Announces $89 Million Series D Financing to Support Broad Fibrosis-Focused Pipeline

                            Details : The proceeds from the financing will be used to further advance the ongoing clinical development of Agomab’s lead candidate, AGMB-129 in patients with fibrostenosing Crohn’s disease (FSCD).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 25, 2024

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Sanofi

                            Deal Size : $89.0 million

                            Deal Type : Series D Financing

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                            05

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Relative Bioavailability and Effect of Food Study With AGMB-129 in Healthy Participants

                            Details : AGMB-129 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 03, 2024

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : EQT Life Sciences

                            Deal Size : $100.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Agomab Raises $100 Million Series C to Advance Fibrosis-focused Pipeline

                            Details : Proceeds will support Phase 2 candidate AGMB-129/ORG-129 for Fibrostenosing Crohn’s Disease and development of a highly innovative pipeline of anti-fibrotic and regenerative therapies, including AGMB-447 for idiopathic pulmonary fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 11, 2023

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : EQT Life Sciences

                            Deal Size : $100.0 million

                            Deal Type : Series C Financing

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                            07

                            AgomAb Therapeutics N.V

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                            IPPE
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                            AgomAb Therapeutics N.V

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                            IPPE
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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Agomab Receives FDA Fast Track Designation for AGMB-129 in Fibrostenosing Crohn’s Disease and Starts STENOVA...

                            Details : AGMB-129 (ORG-129) is an oral, small molecule GI-restricted inhibitor of ALK-5 (or TGFbR1) for the treatment of Fibrostenosing Crohn’s Disease. TGFb is a known master regulator of fibrosis and preliminary clinical data supports targeting the pathway in...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 05, 2023

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            AgomAb Therapeutics N.V

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                            IPPE
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                            AgomAb Therapeutics N.V

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                            IPPE
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                            Lead Product(s) : Ontunisertib,Midazolam

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug-Drug Interaction Study With AGMB-129 and Midazolam in Healthy Participants

                            Details : AGMB-129 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 10, 2023

                            Lead Product(s) : Ontunisertib,Midazolam

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            AgomAb Therapeutics N.V

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                            IPPE
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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn...

                            Details : AGMB-129 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Crohn Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 06, 2023

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            AgomAb Therapeutics N.V

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                            AgomAb Therapeutics N.V

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                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Agomab Reports Positive Phase 1 Results with AGMB-129, a GI-restricted ALK5 Inhibitor for Fibrostenosing Crohn...

                            Details : AGMB-129 (ORG-129) is an oral, small molecule GI-restricted inhibitor of ALK-5 (or TGFbR1) for the treatment of Fibrostenosing Crohn’s Disease. TGFb is a known master regulator of fibrosis and preliminary clinical data supports targeting the pathway in...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 02, 2023

                            Lead Product(s) : Ontunisertib

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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