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Biotech","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Oncolytics Biotech \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Oncolytics Biotech \/ Inapplicable"},{"orgOrder":0,"company":"Oncolytics Biotech","sponsor":"Adlai Nortye","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"Avelumab","moa":"||CD8 T-cell","graph1":"Oncology","graph2":"Phase II","graph3":"Oncolytics Biotech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Oncolytics Biotech \/ Adlai Nortye","highestDevelopmentStatusID":"8","companyTruncated":"Oncolytics Biotech \/ Adlai Nortye"},{"orgOrder":0,"company":"Oncolytics Biotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2020","type":"Inapplicable","leadProduct":"Atezolizumab","moa":"||CD8 T-cell","graph1":"Oncology","graph2":"Phase II","graph3":"Oncolytics Biotech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Oncolytics Biotech \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Oncolytics Biotech \/ Inapplicable"},{"orgOrder":0,"company":"Oncolytics Biotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2020","type":"Inapplicable","leadProduct":"Atezolizumab","moa":"||CD8 T-cell","graph1":"Oncology","graph2":"Phase II","graph3":"Oncolytics Biotech","amount2":0,"highestDevelopmentShortName":"Ph 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                          01

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Reolysin (pelareorep) is an oncolytic reovirus inducing a T cell-inflamed phenotype in PDAC, evaluated with atezolizumab for unresectable squamous cell carcinoma of the anal canal.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          February 14, 2024

                          Lead Product(s) : Pelareorep,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Reolysin (pelareorep), an intravenously delivered immunotherapeutic agent, which is investigated in combination with atezolizumab in second-line patients with unresectable squamous cell carcinoma of the anal canal.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          September 11, 2023

                          Lead Product(s) : Pelareorep,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : The Company intends to use the net proceeds to continue its Reolysin (pelareorep), an intravenously delivered immunotherapeutic agent, clinical programs in metastatic breast cancer and pancreatic cancer.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Undisclosed

                          July 31, 2023

                          Lead Product(s) : Pelareorep,Retifanlimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Leede Jones Gable

                          Deal Size : $15.0 million

                          Deal Type : Public Offering

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                          04

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Results from the trial showed that the combination of Reolysin, Pelareorep-Proteasome Inhibitor was well-tolerated and led to prolonged progression-free survival (PFS) of over three years in a subset of patients.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          October 03, 2022

                          Lead Product(s) : Pelareorep,Dexamethasone,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Reolysin (pelareorep) treatment resulted in a favorable Risk of Recurrence Score (ROR-S) in 100% of evaluable patients compared to 55% at baseline in a window-of-opportunity study.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          April 05, 2022

                          Lead Product(s) : Pelareorep,Atezolizumab,Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : SOLTI-Innovative Cancer Research

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : In IND-213, HR+/HER2- breast cancer patients treated with Reolysin (pelareorep) and paclitaxel showed a statistically significant, near doubling of overall survival compared to those treated with paclitaxel alone.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          March 24, 2022

                          Lead Product(s) : Pelareorep,Avelumab,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Adlai Nortye

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Results showed Reolysin (pelareorep) treatment led to the activation of NK cells, in patient samples and in vitro, which are known to directly kill cancer cells while stimulating adaptive anti-tumor immunity.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          March 17, 2022

                          Lead Product(s) : Pelareorep,Fluorouracil,Calcium Folinate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          08

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : These data highlight the potential of pelareorep to benefit patients with pancreatic and other gastrointestinal cancers by reversing immunosuppressive tumor microenvironments that limit the effectiveness of checkpoint inhibitors.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          February 02, 2022

                          Lead Product(s) : Pelareorep,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Enrollment update provided for GOBLET study for Reolysin (pelareorep) an intravenously delivered immunotherapeutic agent in combination with atezolizumab in patients with metastatic pancreatic, metastatic colorectal, and advanced anal cancers.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          January 20, 2022

                          Lead Product(s) : Pelareorep,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : New clinical data from the AWARE-1 window-of-opportunity breast cancer study showing patients receiving pelareorep plus checkpoint blockade therapy met the trial's primary endpoint.

                          Product Name : Reolysin

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          December 04, 2021

                          Lead Product(s) : Pelareorep,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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