CSBio CSBio

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Hoffmann-La Roche","pharmaFlowCategory":"D","amount":"$1,338.6 million","upfrontCash":"$125.0 million","newsHeadline":"Repare Therapeutics Announces Achievement of $40 Million Roche Clinical Milestone Payment","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"CANADA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Repare Therapeutics"},{"orgOrder":0,"company":"Theralase Technologies","sponsor":"TSX Venture Exchange","pharmaFlowCategory":"D","amount":"$0.8 million","upfrontCash":"Undisclosed","newsHeadline":"Theralase(R) Closes $CAN 1.2 Million Non-Brokered Private Placement","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"CANADA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Theralase Technologies"},{"orgOrder":0,"company":"Repare Therapeutics","sponsor":"F. Hoffmann-La Roche","pharmaFlowCategory":"D","amount":"$1,325.0 million","upfrontCash":"$125.0 million","newsHeadline":"Repare Therapeutics to Regain Global Rights to Camonsertib","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"CANADA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Repare Therapeutics"}]

Find Oncology Drugs in Phase II Clinical Development in CANADA

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            Details:

            Under the termination, Repare will regain global development and commercialization rights to RP-3500 (camonsertib), a potential best-in-class oral small molecule inhibitor of ATR (Ataxia-Telangiectasia and Rad3-related protein kinase).

            Lead Product(s): Camonsertib

            Therapeutic Area: Oncology Product Name: RP-3500

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: F. Hoffmann-La Roche

            Deal Size: $1,325.0 million Upfront Cash: $125.0 million

            Deal Type: Termination February 12, 2024

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            The net proceeds will be used for the development of Ruvidar (TLD-1433), a novel photosensitizer, currently being evaluated in a phase II clinical trial for treating high-risk non-muscle invasive bladder cancer.

            Lead Product(s): TLD-1433

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: TSX Venture Exchange

            Deal Size: $0.8 million Upfront Cash: Undisclosed

            Deal Type: Private Placement February 05, 2024

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            Roche is responsible for the development and commercialization of RP-3500/RG6526 (camonsertib), a potent and selective oral small molecule inhibitor of ATR for the treatment of tumors with specific synthetic-lethal genomic alterations including those in the ATM gene.

            Lead Product(s): Camonsertib

            Therapeutic Area: Oncology Product Name: RG6526

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: F. Hoffmann-La Roche

            Deal Size: $1,338.6 million Upfront Cash: $125.0 million

            Deal Type: Licensing Agreement January 25, 2024

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            TLD-1433 (ruvidar) is a ruthenium-based photodynamic compound. It is under phase 2 clinical development for the treatment of patients with non-muscle invasive bladder cancer.

            Lead Product(s): TLD-1433

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 15, 2024

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            The Company plans to use the proceeds to further the Phase II Non-Muscle Invasive Bladder Cancer (NMIBC) clinical study evaluating Ruvidar (TLD-1433), a light-activated compound.

            Lead Product(s): TLD-1433,Photodynamic Therapy

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Research Capital Corporation

            Deal Size: $0.8 million Upfront Cash: Undisclosed

            Deal Type: Private Placement November 29, 2023

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            The Company plans to use the proceeds to further the Phase II Non-Muscle Invasive Bladder Cancer (NMIBC) clinical study evaluating Ruvidar (TLD-1433), a light-activated compound.

            Lead Product(s): TLD-1433,Photodynamic Therapy

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Research Capital Corporation

            Deal Size: $1.1 million Upfront Cash: Undisclosed

            Deal Type: Private Placement November 17, 2023

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            The net proceeds will be used to fund the Phase 2 clinical trial in late-stage colon cancer evaluating QBECO, an SSI designed to restore innate immune responses in the gastrointestinal tract and related organs, including the liver.

            Lead Product(s): QBECO

            Therapeutic Area: Oncology Product Name: QBECO

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Accelerating Clinical Trial

            Deal Size: $0.2 million Upfront Cash: Undisclosed

            Deal Type: Funding November 14, 2023

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            Details:

            The Company plans to use the proceeds to further the Phase II Non-Muscle Invasive Bladder Cancer (NMIBC) clinical study evaluating Ruvidar (TLD-1433), a light-activated compound.

            Lead Product(s): TLD-1433

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Research Capital Corporation

            Deal Size: $2.6 million Upfront Cash: Undisclosed

            Deal Type: Financing October 23, 2023

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            TLD-1433 on activation by radiation therapy has been demonstrated to be effective in the destruction of human GBM cancer cells. Currently being investigated for non-muscle invasive bladder cancer.

            Lead Product(s): TLD-1433

            Therapeutic Area: Oncology Product Name: TLD-1433

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 23, 2023

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            Ruvidar (TLD-1433), is an exciting new drug candidate for the treatment for NMIBC and has been proven to be safe and effective in a phase Ib clinical study in the safe and effective treatment of NMIBC.

            Lead Product(s): TLD-1433,Photodynamic Therapy

            Therapeutic Area: Oncology Product Name: Ruvidar

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 16, 2023

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