CSBio CSBio

X
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            SAR443579, the first NKp46/CD16-based NK cell engager, is being developed for patients with relapsed or refractory acute myeloid leukemia (R/R AML), B-cell acute lymphoblastic leukemia (B-ALL) or high risk-myelodysplastic syndrome (HR-MDS).

            Lead Product(s): SAR443579

            Therapeutic Area: Oncology Product Name: SAR443579

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 02, 2022

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            ODM-208 is an oral, non-steroidal inhibitor of CYP11A1 currently being evaluated in a Phase 2 clinical trial for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC).

            Lead Product(s): ODM-208,Glucocorticoid,Fludrocortisone Acetate

            Therapeutic Area: Oncology Product Name: ODM-208

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: MSD Pharmaceuticals

            Deal Size: Undisclosed Upfront Cash: $290.0 million

            Deal Type: Collaboration July 13, 2022

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            ODM-208 is a novel, oral, non-steroidal and selective inhibitor of CYP11A1 enzyme developed by Orion for the treatment of prostate cancer. ODM-208 suppresses the production of all steroid hormones and their precursors that may activate AR signalling pathway.

            Lead Product(s): ODM-208,Glucocorticoid,Fludrocortisone Acetate

            Therapeutic Area: Oncology Product Name: ODM-208

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 18, 2022

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            Phase 1/2 first-in-human (FIH) dose escalation and cohort expansion trial evaluating safety and preliminary efficacy of epcoritamab in patients with relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL) published in The Lancet.

            Lead Product(s): Epcoritamab

            Therapeutic Area: Oncology Product Name: GEN3013

            Highest Development Status: Phase I/ Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Genmab

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 09, 2021

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            This next-generation adenine nucleotide translocase (ANT) inhibitor, PENAO, was shown to be safe and well-tolerated in a phase I clinical trial conducted in Australia where encouraging efficacy data was observed.

            Lead Product(s): PENAO,Sirolimus

            Therapeutic Area: Oncology Product Name: PENAO

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: PENAO Pty Ltd

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement August 18, 2021

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            Under the terms of the agreement, AbbVie will be granted an exclusive license to the SHP2 portfolio. Jacobio will continue to conduct early global clinical trials of JAB-3068 and JAB-3312 with AbbVie covering R&D expenses.

            Lead Product(s): JAB-3068

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Jacobio

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration June 01, 2020

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            Company going to present clinical data on its oncology portfolio including data on its Phase 1/2 study of SAR439859, an oral selective estrogen receptor degrader (SERD), in estrogen receptor-positive (ER+)/HER2- metastatic breast cancer.

            Lead Product(s): Amcenestrant,Palbociclib

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 13, 2020

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            The financing proceeds will support the advancement of multiple wholly-owned pipeline programs into clinical studies, including FMC-376 for the treatment of advanced solid tumors with KRAS G12C Mutations.

            Lead Product(s): FMC-376

            Therapeutic Area: Oncology Product Name: FMC-376

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Deerfield Management Company

            Deal Size: $80.0 million Upfront Cash: Undisclosed

            Deal Type: Financing February 22, 2024

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            Through the acquisition, AstraZeneca will focus on the GC012F, clinical-stage FasTCAR-enabled BCMA, and CD19 dual-targeting autologous chimeric antigen receptor T-cell therapy, a potential new treatment for relapsed or refractory multiple myeloma.

            Lead Product(s): GC012F

            Therapeutic Area: Oncology Product Name: GC012F

            Highest Development Status: Phase I/ Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: AstraZeneca

            Deal Size: $1,200.0 million Upfront Cash: $1,000.0 million

            Deal Type: Acquisition February 22, 2024

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            PKI-587 (gedatolisib) is an investigational, intravenously administered pan-class I isoform PI3K and mTOR inhibitor. It is being evaluated in combination with Nubeqa (darolutamide) for the treatment of metastatic castration resistant prostate cancer.

            Lead Product(s): Gedatolisib,Darolutamide

            Therapeutic Area: Oncology Product Name: PKI-587

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2024

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