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                          01

                          ChemOutsourcing
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                          ChemOutsourcing
                          Not Confirmed

                          Details : HQP1351 (olverembatinib) is a 3rd-gen BCR-ABL inhibitor, being developed for newly-diagnosed patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          MD Anderson Cancer Center

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                          ChemOutsourcing
                          Not Confirmed

                          MD Anderson Cancer Center

                          Country arrow
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 10, 2025

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Ascentage Pharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : HQP1351 (olverembatinib) is a novel, potent, & orally administered third-generation tyrosine kinase inhibitor. It is being evaluated for the treatment of SDH-deficient gastrointestinal stromal tumor.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 06, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 15, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : HealthQuest Pharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : HQP1351 (olverembatinib), novel, orally administered 3G BCR-ABL1 inhibitor got CDE approval for its pivotal registrational Phase III study evaluating its efficacy in patients with SDH-deficient GIST.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 06, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : This agreement would allow Takeda to license exclusive global rights to develop and commercialize olverembatinib (BCR-ABL tyrosine kinase inhibitor) in all territories outside of China.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 14, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Takeda Pharmaceutical

                          Deal Size : $1,300.0 million

                          Deal Type : Licensing Agreement

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 21, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Ascentage and Takeda entered into an agreement that granted Takeda an exclusive option to enter into an exclusive license agreement for (HQP1351) olverembatinib for Chronic Myeloid Leukemia.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 07, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Takeda Pharmaceutical

                          Deal Size : $1,300.0 million

                          Deal Type : Agreement

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Ascentage and Takeda entered into an agreement that granted Takeda an exclusive option to enter into an exclusive license agreement for HQP1351 (olverembatinib) for Chronic Myeloid Leukemia.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 07, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Takeda Pharmaceutical

                          Deal Size : $1,300.0 million

                          Deal Type : Agreement

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : HQP1351 (olverembatinib) is a third-generation BCR-ABL inhibitor. It is being developed for the treatment of previously treated adult patients with chronic-phase chronic myeloid leukemia (CML-CP).

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 13, 2024

                          Lead Product(s) : Olverembatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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