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I","graph3":"SpringWorks Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"SpringWorks Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"SpringWorks Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"SpringWorks Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Nirogacestat Hydrobromide","moa":"Gamma-secretase","graph1":"Oncology","graph2":"Approved FDF","graph3":"SpringWorks Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"SpringWorks Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"SpringWorks Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"SpringWorks Therapeutics","sponsor":"Nam Bui","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Nirogacestat Hydrobromide","moa":"Gamma-secretase","graph1":"Oncology","graph2":"Phase III","graph3":"SpringWorks Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"SpringWorks Therapeutics \/ Nam Bui","highestDevelopmentStatusID":"10","companyTruncated":"SpringWorks Therapeutics \/ Nam Bui"}]

Find Clinical Drug Pipeline Developments & Deals for Nirogacestat

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                          Top Deals by Deal Size (USD bn)

                          01

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Nirogacestat HBr is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Desmoid Tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 16, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Nirogacestat is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Desmoid Tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 12, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Nirogacestat HBr is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of undefined medical condition.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 12, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : $3,900.0 million

                          July 01, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Merck Group

                          Deal Size : $3,900.0 million

                          Deal Type : Acquisition

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                          05

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : $3900 million

                          April 28, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Merck Group

                          Deal Size : $3,900.0 million

                          Deal Type : Acquisition

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                          06

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Ogsiveo (nirogacestat) is a USFDA approved oral, selective, small molecule gamma secretase inhibitor. It is being evaluated for the treatment of adults with desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 29, 2024

                          Lead Product(s) : Nirogacestat Hydrobromide,Nirogacestat HBr

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : The net proceeds will be used to support commercialization of Ogsiveo (nirogacestat), approved in the United States for the treatment of adult patients with progressing desmoid tumors who require systemic treatment and continued research and development ...

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          December 08, 2023

                          Lead Product(s) : Nirogacestat Hydrobromide,Nirogacestat HBr

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $316.2 million

                          Deal Type : Public Offering

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                          08

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : The net proceeds will be used to support commercialization of Ogsiveo (nirogacestat), approved in the United States for the treatment of adult patients with progressing desmoid tumors who require systemic treatment and continued research and development ...

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          December 05, 2023

                          Lead Product(s) : Nirogacestat Hydrobromide,Nirogacestat HBr

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $275.0 million

                          Deal Type : Public Offering

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                          09

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : The net proceeds will be used to support commercialization of Ogsiveo (nirogacestat), approved in the United States for the treatment of adult patients with progressing desmoid tumors who require systemic treatment and continued research and development ...

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          December 04, 2023

                          Lead Product(s) : Nirogacestat Hydrobromide,Nirogacestat HBr

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $287.5 million

                          Deal Type : Public Offering

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                          10

                          AllPack Indonesia
                          Not Confirmed
                          AllPack Indonesia
                          Not Confirmed

                          Details : Ogsiveo (nirogacestat) is an investigational gamma secretase inhibitor which is approved by USFDA as the first and only treatment for adults with desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 27, 2023

                          Lead Product(s) : Nirogacestat Hydrobromide,Nirogacestat HBr

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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