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                          01

                          IFT FIRST
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                          IFT FIRST
                          Not Confirmed

                          Details : The multi-year collaboration aims to harness Tempus’ AI-powered data analytics platform, Lens for rapid discovery and innovation in Alzheimer's disease research.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 12, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Northwestern University

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The agreement grants Lilly a worldwide exclusive license to utilize the STAC-BBB capsid for one initial target, to advance potential treatments for neurological diseases.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $18.0 million

                          April 03, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Eli Lilly

                          Deal Size : $1,418.0 million

                          Deal Type : Licensing Agreement

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                          03

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Through the collaboration, Sanofi will leverage their neuroscience expertise and collaborate with Alloy to use the AntiClastic Antisense platform for delivery for treating CNS disease.

                          Product Name : Undisclosed

                          Product Type : Oligonucleotide

                          Upfront Cash : $27.5 million

                          January 07, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Sanofi

                          Deal Size : $427.5 million

                          Deal Type : Collaboration

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                          04

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Under the license agreement, Astellas will leverage Sangamo's novel proprietary neurotropic adeno-associated virus (AAV) capsid, STAC-BBB for the treatment of neurological diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $20.0 million

                          December 19, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Astellas Pharma

                          Deal Size : $1,320.0 million

                          Deal Type : Licensing Agreement

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                          05

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Under the terms of agreement, Vesalius will leverage its platform to identify novel intervention in Parkinson's disease and GSK have the option to advance programs against those intervention points.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $80.0 million

                          December 11, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : GSK

                          Deal Size : $650.0 million

                          Deal Type : Agreement

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                          06

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The collaboration aims to leverage Neomorph's proprietary molecular glue discovery platform to expedite the identification and validation of new small-molecule therapeutics for Alzheimer’s disease.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Biogen

                          Deal Size : $1,450.0 million

                          Deal Type : Collaboration

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                          07

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The collaboartion aims to develop next-generation adeno-associated virus (AAV) vectors for gene therapies targeting neurological diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $50.0 million

                          October 24, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : $1,050.0 million

                          Deal Type : Collaboration

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                          08

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The collaboration of Polku Therapeutics with Expert Systems to focus on the early-stage drug discovery for the treatment of neurodegenerative disorders.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 18, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Polku Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Through the collaboration, Neurocrine has selected a lead development candidate in the GBA1 gene therapy program for the potential treatment of Parkinson’s disease and other GBA1-mediated diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $175.0 million

                          September 16, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Neurocrine Biosciences

                          Deal Size : $1,675.0 million

                          Deal Type : Collaboration

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                          10

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The collaboration aims to develop novel protein degraders to deliver groundbreaking therapeutic candidates for particularly in oncology and central nervous system (CNS) diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          July 10, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : University of Oxford

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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