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    [{"orgOrder":0,"company":"Kronos Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol","moa":"CDK9","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Kronos Bio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Kronos Bio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Kronos Bio \/ Undisclosed"},{"orgOrder":0,"company":"Kronos Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol","moa":"CDK9","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Kronos Bio","amount2":0,"highestDevelopmentShortName":"Ph 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I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Kronos Bio \/ Ignota Labs","highestDevelopmentStatusID":"7","companyTruncated":"Kronos Bio \/ Ignota Labs"}]

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                            01

                            Kronos Bio

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                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Ignota Labs

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Ignota Labs Acquires Kronos’s Clinical Pipeline

                            Details : Under the acquisition of Istisociclib, the deal aims to advance CDK9-targeted therapy for ovarian neoplasms.

                            Product Name : KB-0742

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 06, 2025

                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Ignota Labs

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            02

                            Kronos Bio

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                            Lead Product(s) : KB-7898

                            Therapeutic Area : Immunology

                            Study Phase : Discovery

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Selection of Autoimmune Development Candidate for Sjögren’s Disease

                            Details : KB-7898 is a p300 lysine acetyltransferase (KAT) inhibitor currently in the discovery phase. It has shown strong potential as a treatment for Sjögren’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 07, 2024

                            Lead Product(s) : KB-7898

                            Therapeutic Area : Immunology

                            Highest Development Status : Discovery

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Kronos Bio

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                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces First Patient Dosed with KB-0742 in Ovarian Cancer Expansion Cohort

                            Details : KB-0742, a highly selective, orally bioavailable inhibitor of cyclin-dependent kinase 9, is being developed for the treatment of platinum-resistant high-grade serous ovarian cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 23, 2024

                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Kronos Bio

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                            Lead Product(s) : KB-9558

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Pipeline Update and p300 KAT Inhibitor Development Candidate

                            Details : KB-9558, targets the KAT domain of p300, a critical node of the IRF4 TRN. It is under development for the treatment of patients with multiple myeloma.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 18, 2023

                            Lead Product(s) : KB-9558

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Kronos Bio

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                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Plan to Optimize Resource Allocation, Restructure and Contain Costs Following Positive Pr...

                            Details : KB-0742 is a highly selective, orally bioavailable inhibitor of cyclin dependent kinase 9 (CDK9) in development for the treatment of transcriptionally addicted solid tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 02, 2023

                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Kronos Bio

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Sponsor : Genentech

                            Deal Size : $574.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Discovery Collaboration with Genentech to Advance Novel Therapies Against Transcriptional...

                            Details : Under the collaboration, researchers will use Kronos Bio’s proprietary drug discovery platform, including the small molecule microarray (SMM) for hit finding, to build upon research conducted to date by Genentech.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $20.0 million

                            January 09, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Sponsor : Genentech

                            Deal Size : $574.0 million

                            Deal Type : Collaboration

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                            07

                            Kronos Bio

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                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Selection of Recommended Phase 2 Dose for its Oral CDK9 Inhibitor, KB-0742, After Reachin...

                            Details : The analysis further showed that KB-0742 continues to demonstrate a differentiated pharmacokinetic (PK) profile, with oral bioavailability and dose-proportional exposure across all four dose levels, and low to moderate variability between patients.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 07, 2022

                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Kronos Bio

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                            Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kronos Bio Announces Prioritization of Clinical Portfolio to Focus on Lanraplenib and KB-0742

                            Details : Lanraplenib (Lanra) has demonstrated favorable pharmacokinetic (PK), pharmacodynamic (PD) and safety in more than 250 trial participants, including healthy volunteers and patients with autoimmune diseases.

                            Product Name : Lanra

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 08, 2022

                            Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

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                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Kronos Bio to Present Preclinical Data for KB-0742, an Oral CDK9 Inhibitor Targeting MYC-amplified Cancers, in...

                            Details : KB-0742 is a highly selective, orally bioavailable inhibitor of cyclin dependent kinase 9 (CDK9) and is being developed for the treatment of MYC-amplified and transcriptionally addicted solid tumors and is currently being assessed as part of an ongoing P...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 12, 2022

                            Lead Product(s) : 2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Kronos Bio

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                            AAPS
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                            Kronos Bio

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                            AAPS
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                            Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Kronos Bio Announces First Patient Dosed in Phase 1b/2 Clinical Trial of Lanraplenib in Combination with Gilte...

                            Details : Lanra (lanraplenib) is the company’s next-generation spleen tyrosine kinase (SYK) inhibitor. In addition to lanraplenib, Kronos Bio is also evaluating its lead investigational SYK inhibitor, entospletinib, in the Phase 3 patients with NPM1-mutated AML.

                            Product Name : Lanra

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 22, 2022

                            Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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