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Preclinical Data on NEO-TRA1 at American Society of Hematology (ASH) Annual Meeting","therapeuticArea":"Immunology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"December 2022","url1":"","url2":"","graph1":"Large molecule","graph2":"Neoleukin Therapeutics"},{"orgOrder":0,"company":"Rallybio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Rallybio Announces Publication of Data Highlighting the Ability of HPA-1a-Specific Antibodies to Prevent Alloimmunization in an Authentic Mouse Model of FNAIT","therapeuticArea":"Immunology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"December 2022","url1":"","url2":"","graph1":"Large molecule","graph2":"Rallybio"},{"orgOrder":0,"company":"Silo Pharma","sponsor":"University of 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Pharma","sponsor":"Sanofi","pharmaFlowCategory":"D","amount":"$1,325.0 million","upfrontCash":"Undisclosed","newsHeadline":"Recludix Pharma Enters into a Strategic Collaboration with Sanofi to Advance Novel Oral STAT6 Inhibitor in Multiple Immunological and Inflammatory Indications","therapeuticArea":"Immunology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"July 2023","url1":"","url2":"","graph1":"Small molecule","graph2":"Recludix Pharma"},{"orgOrder":0,"company":"Forte Biosciences","sponsor":"Alger","pharmaFlowCategory":"D","amount":"$25.0 million","upfrontCash":"Undisclosed","newsHeadline":"Forte Biosciences, Inc. 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            The partnership aims to focus on the development of OSE-230, which is an agonist antibody against ChemR23. It is being evaluated in the preclinical trial studies for the treatment of chronic and severe inflammation.

            Lead Product(s): OSE-230

            Therapeutic Area: Immunology Product Name: OSE-230

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: $713.0 million Upfront Cash: $48.0 million

            Deal Type: Partnership February 28, 2024

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            Under the agreement, TG Therapeutics received exclusive worldwide rights to develop and commercialize Precision’s Azercabtagene Zapreleucel (azer-cel), an allogeneic CD19 CAR T cell therapy program for autoimmune diseases and all other non-oncology indications.

            Lead Product(s): Azercabtagene Zapreleucel

            Therapeutic Area: Immunology Product Name: Azer-cel

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: TG Therapeutics

            Deal Size: $305.5 million Upfront Cash: $17.5 million

            Deal Type: Licensing Agreement February 12, 2024

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            The collaboration aims to support the development of selective IL-10 agonists, which play a key role in immune regulation for the treatment of inflammatory diseases.

            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Sanofi

            Deal Size: Undisclosed Upfront Cash: $40.0 million

            Deal Type: Collaboration January 29, 2024

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            The agreement aims for the development of the first oral formulation of ArsciCor (arsenic troxide) in the field of several targeted autoimmune diseases, including for cGvHD treatment.

            Lead Product(s): Arsenic Trioxide

            Therapeutic Area: Immunology Product Name: ArsciCor

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: BioSenic

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement January 15, 2024

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            Under the agreement, Amgen will develop, manufacture, and commercialize a subcutaneous formulation of Tepezza (teprotumumab) using Xeris’ XeriJect® technology in Thyroid Eye Disease (TED).

            Lead Product(s): Teprotumumab

            Therapeutic Area: Immunology Product Name: Tepezza

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Amgen Inc

            Deal Size: $75.0 million Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement January 10, 2024

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            Under the agreement, TG Therapeutics will receive exclusive worldwide rights to develop and commercialize Precision’s Azercabtagene Zapreleucel (azer-cel), an allogeneic CD19 CAR T cell therapy program for autoimmune diseases and all other non-oncology indications.

            Lead Product(s): Azercabtagene Zapreleucel

            Therapeutic Area: Immunology Product Name: Azer-cel

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: TG Therapeutics

            Deal Size: $315.5 million Upfront Cash: $7.5 million

            Deal Type: Licensing Agreement January 09, 2024

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            The net proceeds will be used to support preclinical, clinical, and regulatory activities related to the company’s existing and future product candidate pipeline including COYA-201 which is under preclinical development for autoimmune, metabolic, neurodegenerative disorders.

            Lead Product(s): COYA-201

            Therapeutic Area: Immunology Product Name: COYA-201

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: BTIG, LLC

            Deal Size: $26.5 million Upfront Cash: Undisclosed

            Deal Type: Private Placement December 12, 2023

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            The proceeds will support the advancement of multiple programs for clinical studies of immunology and oncology therapeutics & several of these molecules have the potential to enter the clinical development in next 12 months.

            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Ascenta Capital

            Deal Size: $101.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing December 05, 2023

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            RT-105 (adalimumab) is a monoclonal antibody which inhibits tumor necrosis factor. It binds specifically to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors.

            Lead Product(s): Adalimumab

            Therapeutic Area: Immunology Product Name: RT-105

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 19, 2023

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            By harnessing the immense expertise and resources of both companies, the collaboration aims to accelerate the development of innovative therapeutics for immunological disorders with highly unmet needs.

            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Ingenia Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration October 13, 2023

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