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Details:
The company will use the proceeds from the offering for the development of clinical pipeline including ALPN-303 and for other general and corporate purpose.
Lead Product(s):
ALPN-303
Therapeutic Area: Immunology
Product Name: ALPN-303
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Morgan Stanley
Deal Size: $100.0 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
September 20, 2022
Details:
THB001, is a highly selective, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival.
Lead Product(s):
THB001
Therapeutic Area: Immunology
Product Name: THB001
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Morgan Stanley
Deal Size: $10.9 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
September 14, 2022
Details:
The new data continue to support the favorable safety profile of DSG3-CAART (Desmoglein 3 Chimeric Auto Antibody Receptor T Cells), with no dose-limiting toxicities, and one grade 1 cytokine release syndrome through cohort A5, at a dose of up to 7.5 billion DSG3-CAART cells.
Lead Product(s):
Desmoglein 3 Chimeric Auto Antibody Receptor T-cell Therapy
Therapeutic Area: Immunology
Product Name: DSG3-CAART
Highest Development Status: Phase I
Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 10, 2022
Details:
DSG3-CAART (Desmoglein 3 Chimeric Auto Antibody Receptor T Cells), is being developed to treat mucosal pemphigus vulgaris, a blistering skin disease that affects mucous membranes.
Lead Product(s):
Desmoglein 3 Chimeric Auto Antibody Receptor T Cells
Therapeutic Area: Immunology
Product Name: DSG3-CAART
Highest Development Status: Phase I
Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
University of Pennsylvania
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
August 29, 2022
Details:
Under the terms of the agreement, Horizon will fund development through completion of the two Phase 2 trials of ADX-914, with Q32 being operationally responsible for the conduct of all program-related activities.
Lead Product(s):
ADX-914
Therapeutic Area: Immunology
Product Name: ADX-914
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Horizon Therapeutics
Deal Size: $645.0 million
Upfront Cash: $55.0 million
Deal Type: Collaboration
August 15, 2022
Details:
ARINA-1 (ascorbic acid) is a first-in-class therapy that addresses deficiencies in the innate immune system that occur in chronic inflammatory airway diseases, such as non-CF bronchiectasis, COPD, and lung transplant.
Lead Product(s):
Ascorbic Acid
Therapeutic Area: Immunology
Product Name: ARINA-1
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
August 02, 2022
Details:
The Company intends to use the net proceeds from this offering to further the development of REVTx-99b; further development of REVTx-200 and REVTx-300; continue to develop other products and therapies; and fund working capital and general corporate purposes.
Lead Product(s):
REVTx-99b
Therapeutic Area: Immunology
Product Name: REVTx-99b
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Roth Capital Partners
Deal Size: $5.0 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
July 29, 2022
Details:
The Company intends to use the net proceeds from this offering to further the development of REVTx-99b, REVTx-200 and REVTx-300, and continue to develop other products and therapies, and fund working capital and general corporate purposes using any remaining amounts.
Lead Product(s):
REVTx-99b
Therapeutic Area: Immunology
Product Name: REVTx-99b
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Roth Capital Partners
Deal Size: $5.0 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
July 26, 2022
Details:
The primary endpoint to evaluate the effects of REVTx-99b versus placebo on safety and tolerability was met. Exploratory endpoints for efficacy were not met. REVTx-99b is a proprietary intranasal formulation in development for management of allergic rhinitis symptoms.
Lead Product(s):
REVTx-99b
Therapeutic Area: Immunology
Product Name: REVTx-99b
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 22, 2022
Details:
REVTx-99b, the lead therapeutic candidate, is a proprietary intranasal formulation in development for management of allergic rhinitis symptoms including chronic nasal congestion.
Lead Product(s):
REVTx-99b
Therapeutic Area: Immunology
Product Name: REVTx-99b
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 14, 2022
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