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    [{"orgOrder":0,"company":"Laboratorios SILANES","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"MEXICO","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Losartan Potassium","moa":"||Type-1 angiotensin II receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Laboratorios SILANES","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Laboratorios SILANES \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Laboratorios SILANES \/ Inapplicable"},{"orgOrder":0,"company":"Laboratorios SILANES","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"MEXICO","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Chlorthalidone","moa":"||Thiazide-sensitive sodium-chloride cotransporter","graph1":"Undisclosed","graph2":"Phase I","graph3":"Laboratorios SILANES","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Laboratorios SILANES \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Laboratorios SILANES \/ Inapplicable"},{"orgOrder":0,"company":"Vrije Universiteit Brussel","sponsor":"F. Hoffmann-La Roche | Jessa Hospital","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Acetazolamide","moa":"||Carbonic anhydrase II | Carbonic anhydrase XII | Carbonic anhydrase IV | Carbonic anhydrase I","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Vrije Universiteit Brussel","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous","sponsorNew":"Vrije Universiteit Brussel \/ F. Hoffmann-La Roche | Jessa Hospital","highestDevelopmentStatusID":"11","companyTruncated":"Vrije Universiteit Brussel \/ F. Hoffmann-La Roche | Jessa Hospital"},{"orgOrder":0,"company":"PRM Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Chlorthalidone","moa":"||Thiazide-sensitive sodium-chloride cotransporter","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"PRM Pharma","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"PRM Pharma \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"PRM Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Unichem Laboratories Limited","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"INDIA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Atenolol","moa":"||Adrenergic-beta-1 receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Unichem Laboratories Limited","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Unichem Laboratories Limited \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Unichem Laboratories Limited \/ Inapplicable"},{"orgOrder":0,"company":"Hospital Israelita Albert Einstein","sponsor":"Libbs Farmaceutica","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Candesartan Cilexetil","moa":"||Type-1 angiotensin II receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Hospital Israelita Albert Einstein","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Hospital Israelita Albert Einstein \/ Libbs Farmaceutica","highestDevelopmentStatusID":"10","companyTruncated":"Hospital Israelita Albert Einstein \/ Libbs Farmaceutica"},{"orgOrder":0,"company":"Zydus Lifesciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"INDIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Azilsartan","moa":"||Angiotensin II receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Zydus Lifesciences","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Zydus Lifesciences \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Zydus Lifesciences \/ Inapplicable"},{"orgOrder":0,"company":"Yuhan Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"SOUTH KOREA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Telmisartan","moa":"||Type-1 angiotensin II receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Yuhan Corporation","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Yuhan Corporation \/ Inapplicable","highestDevelopmentStatusID":"11","companyTruncated":"Yuhan Corporation \/ Inapplicable"}]

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                            01

                            PRM Pharma

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            PRM Pharma

                            U.S.A arrow
                            EPSC
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                            Lead Product(s) : Chlorthalidone,Inapplicable

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Approves HemiClor Low-Dose Chlorthalidone for Adult Hypertension

                            Details : HemiClor (12.5 mg chlorthalidone) is a thiazide-like diuretic which is indicated for the treatment of hypertension in adults, to lower blood pressure.

                            Product Name : HemiClor

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 06, 2025

                            Lead Product(s) : Chlorthalidone,Inapplicable

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Zydus Lifesciences

                            India arrow
                            EPSC
                            Not Confirmed

                            Zydus Lifesciences

                            India arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Azilsartan,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Zydus Gets FDA Tentative Approval for Hypertension Tablets

                            Details : Edarbyclor-Generic is an angiotensin II receptor blocker (ARB) and a thiazide like diuretic combination product indicated for the treatment of hypertension.

                            Product Name : Edarbyclor-Generic

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 14, 2024

                            Lead Product(s) : Azilsartan,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Yuhan Corporation

                            South Korea arrow
                            EPSC
                            Not Confirmed

                            Yuhan Corporation

                            South Korea arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Telmisartan,Amlodipine,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients with Essential Hypertension

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 18, 2023

                            Lead Product(s) : Telmisartan,Amlodipine,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Hospital Israelita Albert Einstein

                            Country arrow
                            EPSC
                            Not Confirmed

                            Hospital Israelita Albert Einstein

                            Country arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Candesartan Cilexetil,Chlorthalidone,Amlodipine

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Libbs Farmaceutica

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hyperte...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 27, 2023

                            Lead Product(s) : Candesartan Cilexetil,Chlorthalidone,Amlodipine

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Libbs Farmaceutica

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Vrije Universiteit Brussel

                            Country arrow
                            EPSC
                            Not Confirmed

                            Vrije Universiteit Brussel

                            Country arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Acetazolamide,Bumetanide,Chlorthalidone,Canrenoate,Potassium Chloride

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase IV

                            Sponsor : F. Hoffmann-La Roche | Jessa Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 09, 2022

                            Lead Product(s) : Acetazolamide,Bumetanide,Chlorthalidone,Canrenoate,Potassium Chloride

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase IV

                            Sponsor : F. Hoffmann-La Roche | Jessa Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Laboratorios SILANES

                            Country arrow
                            EPSC
                            Not Confirmed

                            Laboratorios SILANES

                            Country arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Chlorthalidone,Losartan Potassium

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Non-interaction Study of Chlorthalidone and Losartan in Fixed Combination, in Healthy Subjects, Under Fasting ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 22, 2021

                            Lead Product(s) : Chlorthalidone,Losartan Potassium

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Laboratorios SILANES

                            Country arrow
                            EPSC
                            Not Confirmed

                            Laboratorios SILANES

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
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                            Lead Product(s) : Losartan Potassium,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertens...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 15, 2021

                            Lead Product(s) : Losartan Potassium,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Unichem Laboratories Limited

                            India arrow
                            EPSC
                            Not Confirmed

                            Unichem Laboratories Limited

                            India arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Atenolol,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Unichem Labs Receives ANDA Approval for Atenolol and Chlorthalidone Tablets

                            Details : Atenolol and Chlorthalidone Tablets are indicated for the treatment of hypertension, to lower blood pressure. It is generic version of Tenoretic (atenolol and chlorthalidone) tablets.

                            Product Name : Atenolol/Chlorthalidone-Generic

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 28, 2020

                            Lead Product(s) : Atenolol,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Hanmi Pharmaceutical

                            South Korea arrow
                            EPSC
                            Not Confirmed

                            Hanmi Pharmaceutical

                            South Korea arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Amlodipine,Losartan Potassium,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disea...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 11, 2018

                            Lead Product(s) : Amlodipine,Losartan Potassium,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Yuhan Corporation

                            South Korea arrow
                            EPSC
                            Not Confirmed

                            Yuhan Corporation

                            South Korea arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Telmisartan,Amlodipine,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Clinical Trial to Compare the Safety and Pharmacokinetics of YH22162 in Healthy Volunteers

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 07, 2018

                            Lead Product(s) : Telmisartan,Amlodipine,Chlorthalidone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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