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(CYP3A4)","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Vascarta","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Gel","sponsorNew":"Vascarta \/ National Heart, Lung, and Blood Institute","highestDevelopmentStatusID":"6","companyTruncated":"Vascarta \/ National Heart, Lung, and Blood Institute"},{"orgOrder":0,"company":"Jupiter Neurosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Resveratrol","moa":"||NLRP3\/SIRT1","graph1":"Neurology","graph2":"Approved FDF","graph3":"Jupiter Neurosciences","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Jupiter Neurosciences \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"Jupiter Neurosciences \/ Undisclosed"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Nugevia MND, a scientifically formulated supplement, containing reservaterol & curcumin, designed to protect and enhance cognitive function and support overall brain health.

                          Product Name : Nugevia MND

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 11, 2025

                          Lead Product(s) : Resveratrol,Curcumin

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Medinutra LLC

                          Country arrow
                          CAMX
                          Not Confirmed

                          Medinutra LLC

                          Country arrow
                          CAMX
                          Not Confirmed

                          Details : Curcumin is a Plant Extract/Herbal drug candidate, which is currently being evaluated in clinical studies for the treatment of Inflammation.

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          July 14, 2025

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Immunology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Under the agreement, the National Heart, Lung, and Blood Institute will perform a human phase I clinical trial of Vascarta's VAS-101 (Vasceptor; topical curcumin gel) in Sickle Cell Disease (SCD).

                          Product Name : Vasceptor

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 07, 2025

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : National Heart, Lung, and Blood Institute

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          04

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : VAS-101 (vasceptor) is a patented topical curcumin formulation that is delivered using patented transdermal technology.

                          Product Name : Vasceptor

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 12, 2025

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : VAS-101 is a topical curcumin formulation, which is being evaluated in the early-satge clinical studies for the treatment of Sickle Cell Disease.

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          April 15, 2025

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : VAS101 is a highly concentrated curcumin gel formulation that employs a patented topical/transdermal delivery platform. It is being evaluated for the treatment of knee osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          March 18, 2025

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : The collaboration aims to advance the clinical development of a therapy that links anti-cancer agents, such as Gemzar (gemcitabine), with curcumin to enhance the effectiveness in treating cancer.

                          Product Name : Gemzar

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Undisclosed

                          January 13, 2025

                          Lead Product(s) : Gemcitabine,Curcumin

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : CUNY

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Blink NutriTears is a clinically proven nutritional supplement developed to help relieve dry eye symptoms. It contains a proprietary blend of lutein, zeaxanthin, curcumin, & vitamin D.

                          Product Name : Blink NutriTears

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          March 06, 2024

                          Lead Product(s) : Lutein,Curcumin,Zeaxanthin

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          COD Research

                          Country arrow
                          CAMX
                          Not Confirmed

                          COD Research

                          Country arrow
                          CAMX
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          February 13, 2024

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          National Institute of Cancerología

                          Country arrow
                          CAMX
                          Not Confirmed

                          National Institute of Cancerología

                          Country arrow
                          CAMX
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          October 12, 2023

                          Lead Product(s) : Curcumin

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Sabinsa

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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