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Find Clinical Drug Pipeline Developments & Deals by Exscientia
Uner the collaboration, Merck will leverage Exscientia’s AI-driven precision drug design and discovery capabilities in oncology and neuroinflammation. Three potential first-in-class or best-in-class targets have been identified as the initial focus of the partnership.
GTAEXS617 Exscientia’s precision-designed CDK7 inhibitor, which is investigated for the treatment of advanced solid tumours including head and neck cancer, colorectal cancer, pancreatic cancer, non-small cell lung cancer (NSCLC), HR+/HER2- breast carcinoma and ovarian cancer.
DSP-2342 is a highly-selective bispecific small molecule with potent dual 5-HT2A and 5-HT7 antagonist activity with broad potential in psychiatric disease.
EXS74539 is a differentiated LSD1 inhibitor with potential in both haematology and oncology. LSD1 demethylates histones which regulates gene expression suppressing differentiation and drive the proliferation and survival of a number of tumour types.
EXS4318 is a PKC theta inhibitor which plays a critical role in controlling T cell function and is a key driver of several highly prevalent autoimmune diseases. PKC theta inhibitors have potential in inflammatory and immunologic diseases.
EXS-21546 ('546), Exscientia’s A2A receptor antagonist in combination with anti-PD-1 therapy in patients with immunotherapy relapsed or refractory renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC).
GTAEXS-617 is novel CDK7 inhibitor designed for high potency, selectivity, bioavailability and safety. CDK7 inhibition combines cell cycle disruption with transcription inhibition, making it an attractive target to overcome common resistance pathways in CDK4/6 inhibition.
EXALT-1 was the rst prospective trial to demonstrate signicantly improved outcomes for late-stage haematological cancer patients using an AI-supported precision medicine platform to guide personalised treatment recommendations as compared to physician’s choice of treatment.
The study showed that observed human PK for EXS-21546 was in line with what had been designed for and predicted in preclinical modeling, supporting a twice-daily (BID) dose for continuous A2A receptor inhibition over a dosing interval.
Exscientia designed an orally bioavailable, highly potent and selective small-molecule antagonist of CDK7, GTAEXS-617, currently in IND-enabling studies as a potential treatment for transcriptionally addicted cancers, including EXS21546.
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