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Therapeutics","sponsor":"Celltrion","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Partnership","leadProduct":"Ustekinumab","moa":"IL-12 receptor","graph1":"Dermatology","graph2":"Phase I","graph3":"Rani Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Rani Therapeutics \/ Celltrion","highestDevelopmentStatusID":"6","companyTruncated":"Rani Therapeutics \/ Celltrion"},{"orgOrder":0,"company":"Immunic Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"IMU-935","moa":"ROR-gamma","graph1":"Dermatology","graph2":"Phase I","graph3":"Immunic Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"IMU-935","moa":"ROR-gamma","graph1":"Dermatology","graph2":"Phase I","graph3":"Immunic Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Immunic Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Immunic Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"vTv Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"HPP737","moa":"PDE4","graph1":"Dermatology","graph2":"Phase I","graph3":"vTv Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"DICE Therapeutics","sponsor":"RA Capital Management","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Series C Financing","leadProduct":"S011806","moa":"IL-17 receptor","graph1":"Dermatology","graph2":"Phase I","graph3":"DICE Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"DICE Therapeutics \/ RA Capital Management","highestDevelopmentStatusID":"6","companyTruncated":"DICE Therapeutics \/ RA Capital Management"},{"orgOrder":0,"company":"DICE Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"S011806","moa":"IL-17 receptor","graph1":"Dermatology","graph2":"Phase I","graph3":"DICE 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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Xyngari","moa":"IL-17A receptor","graph1":"Dermatology","graph2":"Phase I","graph3":"Dermata Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Powder","sponsorNew":"Dermata Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Dermata Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Jeune Aesthetics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"KB301","moa":"COL3A1","graph1":"Dermatology","graph2":"Phase I","graph3":"Jeune Aesthetics","amount2":0,"highestDevelopmentShortName":"Ph 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Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Rubedo Life Sciences \/ Inapplicable"},{"orgOrder":0,"company":"Enveda Bioscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"ENV-294","moa":"JAK","graph1":"Dermatology","graph2":"Phase I","graph3":"Enveda Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Enveda Bioscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Enveda Bioscience \/ Inapplicable"},{"orgOrder":0,"company":"Kymera Therapeutics","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"KT-621","moa":"STAT6","graph1":"Dermatology","graph2":"Phase I","graph3":"Kymera Therapeutics","amount2":0.25,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0.25,"dosageForm":"Oral Pill","sponsorNew":"Kymera Therapeutics \/ Morgan Stanley","highestDevelopmentStatusID":"6","companyTruncated":"Kymera Therapeutics \/ Morgan Stanley"},{"orgOrder":0,"company":"Kymera Therapeutics","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"KT-621","moa":"STAT6","graph1":"Dermatology","graph2":"Phase I","graph3":"Kymera Therapeutics","amount2":0.25,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0.25,"dosageForm":"Oral Pill","sponsorNew":"Kymera Therapeutics \/ Morgan Stanley","highestDevelopmentStatusID":"6","companyTruncated":"Kymera Therapeutics \/ Morgan Stanley"}]

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                          01

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The proceeds from the offering will be used to fund the clinical development of kymera pipeline, which includes KT-621, an oral degrader of STAT6, being evaluated for Atopic Dermatitis.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 26, 2025

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $250.8 million

                          Deal Type : Public Offering

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                          02

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The proceeds from the offering will be used to fund the clinical development of kymera pipeline, which includes KT-621, an oral degrader of STAT6, being evaluated for Atopic Dermatitis.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 25, 2025

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $250.0 million

                          Deal Type : Public Offering

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                          03

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : RLS-1496, the First GPX4 Modulator, small molecule drug candidate, which is being evaluated for the treatment of mild to moderate and stable plaque psoriasis.

                          Product Name : RLS-1496

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 22, 2025

                          Lead Product(s) : RLS-1496

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : QRX003 is a topical lotion formulated with Invisicare and contains a broad-spectrum serine protease inhibitor, being developed for peeling skin syndrome.

                          Product Name : QRX003

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 14, 2025

                          Lead Product(s) : QRX003

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : CPI-818 (soquelitinib) is a covalent ITK inhibitor, blocks ITK activity, currently being investigated for the treatment of moderate to severe atopic dermatitis.

                          Product Name : CPI-818

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 08, 2025

                          Lead Product(s) : Soquelitinib

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : VYN202 is a potential best-in-class oral small molecule BD2-Selective BET inhibitor, which is being evaluated for the treatment of plaque psoriasis.

                          Product Name : VYN202

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 25, 2025

                          Lead Product(s) : VYN202

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : KT-621 is a first-in-class oral STAT6 degrader, small molecule drug candidate, which is currently being evaluated for the treatment of atopic dermatitis.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 22, 2025

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : SFA002 is an oral drug for the treatment of mild-moderate psoriasis. It has a potential multi-target and disease-modifying therapeutic that has demonstrated efficacy, safety and durability.

                          Product Name : SFA-002

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : SFA-002

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : APG990 is a novel, SQ, half-life extended mAb targeting OX40L

                          Product Name : APG990

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 03, 2025

                          Lead Product(s) : APG990

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The financing aims to advance the development of company's pipeline, which includes ENV-294, a first-in-class, oral small molecule, with JAK-inhibitor. It is being evaluated for Atopic Dermatitis.

                          Product Name : ENV-294

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 26, 2025

                          Lead Product(s) : ENV-294

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Sanofi

                          Deal Size : $150.0 million

                          Deal Type : Series C Financing

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