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Details:
Ventyx intends to use the net proceeds from the proposed private placement, to fund the clinical development of VTX958, VTX002, VTX2735 and VTX3232, the preclinical development of other programs, research activities and working capital and other general corporate purposes.
Lead Product(s):
VTX958
Therapeutic Area: Dermatology
Product Name: VTX958
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Redmile Group
Deal Size: $176.6 million
Upfront Cash: Undisclosed
Deal Type: Private Placement
September 19, 2022
Details:
FRTX-02 is potent, highly selective, and orally bioavailable potential first-in-class DYRK1A inhibitor that aims to restore immune balance by modulating both adaptive and innate immune responses in patients with autoimmune and inflammatory diseases.
Lead Product(s):
FRTX-02
Therapeutic Area: Dermatology
Product Name: FRTX-02
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 13, 2022
Details:
LY3471851/NKTR-358 (rezpegaldesleukin) is a novel, selective regulatory T-cell inducing IL-2 conjugate designed to target immune system imbalance that results from increased levels of inflammatory T cells and reduced numbers and impaired function of regulatory T cells.
Lead Product(s):
Rezpegaldesleukin
Therapeutic Area: Dermatology
Product Name: NKTR-358
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Eli Lilly
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 07, 2022
Details:
RBN-3143, a first-in-class, orally administered, small molecule inhibitor of PARP14, has the potential to be a differentiated therapy for the treatment of numerous inflammatory diseases.
Lead Product(s):
RBN-3143
Therapeutic Area: Dermatology
Product Name: RBN-3143
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 06, 2022
Details:
VTX958 is an oral, selective allosteric inhibitor of tyrosine kinase 2 (TYK2). TYK2 regulates both innate and adaptive immunity by mediating IFNα, IL-12 and IL-23 signaling.
Lead Product(s):
VTX958
Therapeutic Area: Dermatology
Product Name: VTX958
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
August 15, 2022
Details:
DC-806 is an orally-available, small molecule antagonist of the pro-inflammatory cytokine, interleukin-17 (IL-17), which is a validated drug target for the treatment of a variety of autoimmune and inflammatory diseases, including psoriasis.
Lead Product(s):
DC-806
Therapeutic Area: Dermatology
Product Name: DC-806
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 21, 2022
Details:
BioLexa is a patented, proprietary antimicrobial topical formulation being developed for treatment of diseases mediated by Staphylococcal biofilms for patients suffering with Atopic Dermatitis.
Lead Product(s):
BioLexa
Therapeutic Area: Dermatology
Product Name: BioLexa
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
June 21, 2022
Details:
The dose-ranging, randomized, double-blind, vehicle-controlled study will enroll 10 patients to evaluate the safety and tolerability of STP705, which will be delivered via subcutaneous injection.
Lead Product(s):
STP705
Therapeutic Area: Dermatology
Product Name: STP705
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 27, 2022
Details:
In preclinical studies, ADX-097 demonstrated the potential to potently inhibit disease-causing complement activation in the tissue while avoiding systemic complement inhibition.
Lead Product(s):
ADX-097
Therapeutic Area: Dermatology
Product Name: ADX-097
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 26, 2022
Details:
The poster presentation highlights broad impact of KT-474 across multiple disease-relevant cell types and supports continued development of IRAK4 degraders in patients where IRAK4 plays a central role in the pathogenesis of inflammation.
Lead Product(s):
KT-474
Therapeutic Area: Dermatology
Product Name: KT-474
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 20, 2022
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