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    [{"orgOrder":0,"company":"University Hospital, Basel","sponsor":"European Union | State Secretariat for Education Research and Innovation Switzerland | Olatec Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"SWITZERLAND","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Endocrinology","graph2":"Phase II","graph3":"University Hospital, Basel","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University Hospital, Basel \/ European Union | State Secretariat for Education Research and Innovation Switzerland | Olatec Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"University Hospital, Basel \/ European Union | State Secretariat for Education Research and Innovation Switzerland | Olatec Therapeutics"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"CTI Clinical Trial and Consulting","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Olatec Therapeutics \/ CTI Clinical Trial and Consulting","highestDevelopmentStatusID":"8","companyTruncated":"Olatec Therapeutics \/ CTI Clinical Trial and Consulting"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Michael J. Fox Foundation for Parkinson\u2019s Research","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Funding","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Neurology","graph2":"Phase I","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Olatec Therapeutics \/ Michael J. Fox Foundation for Parkinson\u2019s Research","highestDevelopmentStatusID":"6","companyTruncated":"Olatec Therapeutics \/ Michael J. Fox Foundation for Parkinson\u2019s Research"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Olatec Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Olatec Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Neurology","graph2":"Phase I","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Olatec Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Olatec Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Rheumatology","graph2":"Phase II\/ Phase III","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Olatec Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Olatec Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Sanders Morris Harris","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Series A Financing","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Rheumatology","graph2":"Phase II\/ Phase III","graph3":"Olatec Therapeutics","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Rheumatology","amount2New":0.040000000000000001,"dosageForm":"Tablet","sponsorNew":"Olatec Therapeutics \/ Sanders Morris Harris","highestDevelopmentStatusID":"9","companyTruncated":"Olatec Therapeutics \/ Sanders Morris Harris"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"||NACHT, LRR and PYD domains-containing protein 3","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Olatec Therapeutics \/ Merck & Co","highestDevelopmentStatusID":"7","companyTruncated":"Olatec Therapeutics \/ Merck & Co"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Endocrinology","graph2":"Phase II","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Olatec Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Olatec Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Olatec Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Neurology","graph2":"Preclinical","graph3":"Olatec Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Olatec Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Olatec Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"April Salama","sponsor":"Merck & Co | Olatec Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"April Salama","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"April Salama \/ Merck & Co | Olatec Therapeutics","highestDevelopmentStatusID":"7","companyTruncated":"April Salama \/ Merck & Co | Olatec Therapeutics"},{"orgOrder":0,"company":"Cambridge University Hospitals NHS Foundation Trust","sponsor":"University of Cambridge | Olatec Therapeutics | Cure Parkinson's | Van Andel Research Institute","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Dapansutrile","moa":"NACHT, LRR and PYD domains-containing protein 3","graph1":"Neurology","graph2":"Phase II","graph3":"Cambridge University Hospitals NHS Foundation Trust","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Cambridge University Hospitals NHS Foundation Trust \/ University of Cambridge | Olatec Therapeutics | Cure Parkinson's | Van Andel Research Institute","highestDevelopmentStatusID":"8","companyTruncated":"Cambridge University Hospitals NHS Foundation Trust \/ University of Cambridge | Olatec Therapeutics | Cure Parkinson's | Van Andel Research Institute"}]

    Find Clinical Drug Pipeline Developments & Deals for Dapansutrile

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                            01

                            Cambridge University Hospitals NHS Foundation Trust

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                            Cambridge University Hospitals NHS Foundation Trust

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Sponsor : University of Cambridge | Olatec Therapeutics | Cure Parkinson's | Van Andel Research Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease

                            Details : Dapansutrile is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Parkinson Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 05, 2025

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Sponsor : University of Cambridge | Olatec Therapeutics | Cure Parkinson's | Van Andel Research Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            First Patient Enrolled in Phase 2 Study of Dapansutrile for Type 2 Diabetes

                            Details : OLT1177 (dapansutrile) is an oral NLRP3 Inhibitor small molecule drug candidate, which is being evaluated for the treatment of patients with type 2 diabetes mellitus.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 11, 2024

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Olatec Therapeutics to Conduct Phase 2 Trial in Patients with Early Parkinson’s Disease

                            Details : OLT1177 (dapansutrile) is an oral NLRP3 Inhibitor, which is being evaluated for the treatment of patients with early parkinson’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 20, 2024

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            University Hospital, Basel

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                            University Hospital, Basel

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase II

                            Sponsor : European Union | State Secretariat for Education Research and Innovation Switzerland | Olatec Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Dapansutrile in Diabetes and Diabetes-Related Complications - Dapan-Dia

                            Details : Dapansutrile is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Diabetes Mellitus, Type 2.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 21, 2023

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase II

                            Sponsor : European Union | State Secretariat for Education Research and Innovation Switzerland | Olatec Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Olatec Therapeutics Announces the Completion of First Dose Cohort in an Innovative Trial Investigating Olatecâ...

                            Details : OLT1177 (dapansutrile) is an NLRP3 inhibitor which is being investigated in combination with pembrolizumab (Keytruda®) in patients with PD-1 refractory advanced melanoma.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 16, 2023

                            Lead Product(s) : Dapansutrile,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Michael J. Fox Foundation for Parkinson’s Research

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Olatec Therapeutics Awarded a Grant from The Michael J. Fox Foundation in Collaboration With Medical Universit...

                            Details : The Michael J. Fox Foundation for Parkinson’s Research has awarded a grant from their Therapeutics Pipeline Program to support preclinical research evaluating Olatec Therapeutics’ lead compound, OLT1177 (dapansutrile), an investigational small molecu...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            March 10, 2023

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Michael J. Fox Foundation for Parkinson’s Research

                            Deal Size : Undisclosed

                            Deal Type : Funding

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                            07

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Sanders Morris Harris

                            Deal Size : $40.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            Olatec Therapeutics Announces the Final Closing, Led by Sanders Morris Harris, on Its $40 Million Series A Fin...

                            Details : The net proceeds will be used to advance OLT1177 (dapansutrile) into later stage clinical development. Dapansutrile is an investigational small molecule, that specifically binds to and blocks NLRP3, the sensor molecule integral in the formation of the NL...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 23, 2023

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Sanders Morris Harris

                            Deal Size : $40.0 million

                            Deal Type : Series A Financing

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                            08

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

                            Details : Dapansutrile is a Other Small Molecule drug candidate, which is currently being evaluated in phase II/ phase III clinical studies for the treatment of Gout.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 20, 2022

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            April Salama

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                            April Salama

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Merck & Co | Olatec Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma

                            Details : Dapansutrile is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Melanoma.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 21, 2021

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Merck & Co | Olatec Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Olatec Therapeutics

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                            Olatec Therapeutics

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                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Olatec Therapeutics’ Dapansutrile Prevents the Inflammatory Response, Restores Cognitive and Behavioral Defi...

                            Details : Results suggest a potential therapeutic benefit for dapansutrile in patients with neuroinflammatory diseases, e.g., Alzheimer’s Disease. Preclinical results encourage clinical research with dapansutrile in Alzheimer’s Disease to investigate therapeut...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 29, 2020

                            Lead Product(s) : Dapansutrile

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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