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    [{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Leukemia and Lymphoma Society","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase I","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society","highestDevelopmentStatusID":"6","companyTruncated":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Leukemia and Lymphoma Society","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2014","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase I","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society","highestDevelopmentStatusID":"6","companyTruncated":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Leukemia and Lymphoma Society","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2014","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Leukemia and Lymphoma Society"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase I","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"MorphoSys","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Acquisition","leadProduct":"Pelabresib","moa":"||Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":1.7,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":1.7,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ 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Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Pelabresib","moa":"Bromodomain and extra-terminal motif (BET)","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"CPI-1205","moa":"Enhancer of zeste homolog 2 (EZH2)","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"CPI-1205","moa":"Enhancer of zeste homolog 2 (EZH2)","graph1":"Oncology","graph2":"Phase I","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2015","type":"Inapplicable","leadProduct":"CPI-1205","moa":"Enhancer of zeste homolog 2 (EZH2)","graph1":"Oncology","graph2":"Phase I","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Constellation Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Constellation Pharmaceuticals \/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals by Constellation Pharmaceuticals

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                            01

                            Constellation Pharmaceuticals

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                            Constellation Pharmaceuticals

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                            BOS Manchester
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                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

                            Details : Pelabresib is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Hematologic Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 06, 2024

                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
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                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies

                            Details : Pelabresib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 25, 2022

                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
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                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Constellation Pharmaceuticals Provides an Update from the Ongoing MANIFEST Study of Pelabresib

                            Details : Pelabresib durably reduced inflammatory cytokines such as tumor necrosis factor alpha (TNF alpha) and interleukin 18 (IL18) as early as 2 weeks and maintained through 24 weeks of treatment, based on an analysis of patient samples.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 11, 2021

                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : MorphoSys

                            Deal Size : $1,700.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Morphosys to Buy Constellation in $1.7B Deal, Aided by Unusual Funding

                            Details : Constellation's lead product candidates, pelabresib (CPI-0610), a BET inhibitor, and CPI-0209, a 2nd-gen EZH2 inhibitor, are in mid- to late-stage clinical trials and have broad therapeutic potential to offer benefits to patients with various hematologic...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $1,700.0 million

                            June 02, 2021

                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : MorphoSys

                            Deal Size : $1,700.0 million

                            Deal Type : Acquisition

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                            05

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Constellation Pharmaceuticals to Host Analyst / Investor Event to Discuss Update of MANIFEST Trial for CPI-061...

                            Details : Event includes a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50-60 first line and 90-100 second line myelofibrosis patients. MANIFEST is an open-label Phase 2 trial of CPI-0610 in patients...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 23, 2020

                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

                            Details : Pelabresib is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Primary Myelofibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 26, 2020

                            Lead Product(s) : Pelabresib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Constellation Pharmaceuticals

                            U.S.A arrow
                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Constellation Pharmaceuticals Provides Updates of MANIFEST Study for CPI-0610 and EZH2 Franchise

                            Details : 37 of 51 evaluable patients (73%) achieved a 35% reduction in spleen volume (SVR35) at 12 weeks and had a median spleen volume reduction of 51% after receiving Arm 3 (1L) – CPI-0610 + ruxolitinib.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 12, 2020

                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Constellation Pharmaceuticals

                            U.S.A arrow
                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Constellation Pharmaceuticals Provides Update of Preliminary Data for CPI-0610 in Three EHA Abstracts

                            Details : Evidence of clinical activity was seen both as monotherapy and in combination with ruxolitinib. If these preliminary data are confirmed in further testing, CPI-0610 could become part of a new standard of care in myelofibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 14, 2020

                            Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : CPI-1205

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors

                            Details : CPI-1205 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 16, 2018

                            Lead Product(s) : CPI-1205

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Constellation Pharmaceuticals

                            U.S.A arrow
                            BOS Manchester
                            Not Confirmed

                            Constellation Pharmaceuticals

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                            BOS Manchester
                            Not Confirmed
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                            Lead Product(s) : CPI-1205

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer

                            Details : CPI-1205 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Prostatic Neoplasms, Castration-Resistant.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 29, 2018

                            Lead Product(s) : CPI-1205

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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