[{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||BET","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||BET","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||BET","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Pelabresib","moa":"||BET","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Constellation Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Constellation Pharmaceuticals","sponsor":"MorphoSys","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Acquisition","leadProduct":"Pelabresib","moa":"||BET","graph1":"Oncology","graph2":"Phase III","graph3":"Constellation Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Constellation Pharmaceuticals \/ MorphoSys","highestDevelopmentStatusID":"10","companyTruncated":"Constellation Pharmaceuticals \/ MorphoSys"}]

Find Clinical Drug Pipeline Developments & Deals by Constellation Pharmaceuticals

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                          Top Deals by Deal Size (USD bn)

                          01

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Pelabresib durably reduced inflammatory cytokines such as tumor necrosis factor alpha (TNF alpha) and interleukin 18 (IL18) as early as 2 weeks and maintained through 24 weeks of treatment, based on an analysis of patient samples.

                          Product Name : CPI-0610

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 06, 2021

                          Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Constellation's lead product candidates, pelabresib (CPI-0610), a BET inhibitor, and CPI-0209, a 2nd-gen EZH2 inhibitor, are in mid- to late-stage clinical trials and have broad therapeutic potential to offer benefits to patients with various hematologic...

                          Product Name : CPI-0610

                          Product Type : Other Small Molecule

                          Upfront Cash : $1,700.0 million

                          February 06, 2021

                          Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : MorphoSys

                          Deal Size : $1,700.0 million

                          Deal Type : Acquisition

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : 37 of 51 evaluable patients (73%) achieved a 35% reduction in spleen volume (SVR35) at 12 weeks and had a median spleen volume reduction of 51% after receiving Arm 3 (1L) – CPI-0610 + ruxolitinib.

                          Product Name : CPI-0610

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 06, 2020

                          Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Event includes a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50-60 first line and 90-100 second line myelofibrosis patients. MANIFEST is an open-label Phase 2 trial of CPI-0610 in patients...

                          Product Name : CPI-0610

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 23, 2020

                          Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Evidence of clinical activity was seen both as monotherapy and in combination with ruxolitinib. If these preliminary data are confirmed in further testing, CPI-0610 could become part of a new standard of care in myelofibrosis.

                          Product Name : CPI-0610

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 14, 2020

                          Lead Product(s) : Pelabresib,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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