Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Genetic Disease
Study Phase : Undisclosed
Sponsor : Crosswalk Therapeutics
Deal Size : Undisclosed
Deal Type : Acquisition
Codexis Finalizes Purchase Agreement with Crosswalk Therapeutics for Gene Therapy Assets
Details : Through the acquisition, Crosswalk will gain Codexis' investigational AAV based gene therapy, that is being developed to target fabry and pompe diseases.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
January 07, 2024
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Genetic Disease
Highest Development Status : Undisclosed
Sponsor : Crosswalk Therapeutics
Deal Size : Undisclosed
Deal Type : Acquisition
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Study Phase : Phase I
Recipient : Nestle Health Sciences SA
Deal Size : $50.0 million
Deal Type : Agreement
Codexis Announces Purchase Agreement with Nestlé Health Science for CDX-7108
Details : Through agreement, Nestlé Health Science will be solely responsible for the continued development and commercialization of CDX-7108, an investigational therapy for the potential treatment of exocrine pancreatic insufficiency (EPI).
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : $5.0 million
December 27, 2023
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Recipient : Nestle Health Sciences SA
Deal Size : $50.0 million
Deal Type : Agreement
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CDX-7108 is an orally administered therapeutic lipase enzyme variant specifically engineered to overcome the limitations of existing pancreatic enzyme replacement therapy (PERT). PERT is the main treatment for exocrine pancreatic insufficiency (EPI).
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
February 23, 2023
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nirmatrelvir,Ritonavir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved FDF
Sponsor : Pfizer Inc
Deal Size : Undisclosed
Deal Type : Agreement
Details : The unique enzyme is an important element in the manufacture of PAXLOVID™ (ritonavir) and plays a role in supporting the efforts to ensure rapid availability of this COVID-19 oral treatment to people around the world.
Product Name : Paxlovid
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
July 14, 2022
Lead Product(s) : Nirmatrelvir,Ritonavir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved FDF
Sponsor : Pfizer Inc
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : CDX-6316,Inapplicable
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Takeda Pharmaceutical
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Pre-clinical data highlights enzyme variants engineered with Codexis’ CodeEvolver® platform to offer potentially improved efficacy as compared to current enzymes when administered as transgenes in gene therapies for Hemophilia A, Fabry Disease, and Po...
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 16, 2022
Lead Product(s) : CDX-6316,Inapplicable
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Takeda Pharmaceutical
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Discovery
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Codexis to Present Data Highlighting Three Gene Therapy Programs at the ASGCT 25th Annual Meeting
Details : Two poster to be presentated highlighting three of the Company’s gene therapy programs using directed evolution to potentially improve treatment options for Hemophilia A and lysosomal storage diseases.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
February 05, 2022
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Discovery
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CDX-6512,Inapplicable
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CDX-6512, a gastrointestinal-stable methionine-gamma-lyase as a potential orally-administered enzyme therapy for homocystinuria, which demonstrated up to a 45% suppression in serum total homocysteine.
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
November 22, 2021
Lead Product(s) : CDX-6512,Inapplicable
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sitagliptin Phosphate,Inapplicable
Therapeutic Area : Endocrinology
Study Phase : Approved FDF
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Agreement
Codexis and Merck Amend and Extend Supply Agreement for Enzyme Used in Manufacture of Sitagliptin
Details : Under a research and development agreement, Codexis and Merck leveraged Codexis’ CodeEvolver® enzyme engineering platform technology to design a novel, proprietary enzyme to serve as a biocatalyst in the sitagliptin manufacturing process.
Product Name : Januvia
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
September 09, 2021
Lead Product(s) : Sitagliptin Phosphate,Inapplicable
Therapeutic Area : Endocrinology
Highest Development Status : Approved FDF
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Undisclosed
Sponsor : GSK
Deal Size : $25.0 million
Deal Type : Collaboration
Codexis Earns Milestone Payment from GlaxoSmithKline
Details : This milestone marks the advancement of the commercialization of an enzyme, generated using CodeEvolver under the licensing agreement, that is engineered to improve a key step in the manufacturing process for a currently undisclosed drug.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $6.0 million
July 07, 2021
Lead Product(s) : Undisclosed,Inapplicable
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Undisclosed
Sponsor : GSK
Deal Size : $25.0 million
Deal Type : Collaboration
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CDX-7108 is a lipase variant specifically engineered to overcome the limitations of traditional pancreatic enzyme replacement therapy (PERT) deficiencies. CDX-7108 is highly stable to the acidic conditions in the stomach and resistant to proteases in the...
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
March 11, 2021
Lead Product(s) : CDX-7108,Inapplicable
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable