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    [{"orgOrder":0,"company":"Checkpoint Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Checkpoint Therapeutics Announces Issuance of U.S. Composition of Matter Patent for Anti-PD-L1 Antibody Cosibelimab","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Checkpoint Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Checkpoint Therapeutics to Present Cosibelimab Interim Results from Registration-Enabling Trial at ESMO Virtual Congress 2020","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"July 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Checkpoint Therapeutics","sponsor":"H.C. 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              Checkpoint Therapeutics Announces $14 Million Registered Direct Offering Priced at-the-Market

              Details:

              The net proceeds will be used in the development of CK-301 (cosibelimab), which is an anti-programmed death-ligand for the treatment of patients with selected recurrent or metastatic cancers, including metastatic and locally advanced cutaneous squamous cell carcinoma.

              Lead Product(s): Cosibelimab

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $14.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering January 29, 2024

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              US FDA Declines to Approve Checkpoint Therapeutics' Skin Cancer Therapy

              Details:

              CK-301 (cosibelimab) is a fully-human mAb of IgG1 subtype that directly binds to PD-L1 and blocks the PDL1 interaction with the PD-1 and B7.1 receptors. It is under phase 3 clinical development for the treatment of cutaneous squamous cell carcinoma.

              Lead Product(s): Cosibelimab

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 18, 2023

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              Checkpoint Therapeutics Announces Exercise of Warrants for $11.13 Million in Gross Proceeds

              Details:

              Checkpoint intends to use the proceeds for the manufacturing of CK-301 (cosibelimab), a potential best-in-class anti-PD-L1 antibody being developed in patients with selected recurrent or metastatic cancers.

              Lead Product(s): Cosibelimab

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $11.1 million Upfront Cash: Undisclosed

              Deal Type: Public Offering October 02, 2023

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              Checkpoint Therapeutics Announces $10 Million Registered Direct Offering Priced at-the-Market

              Details:

              Checkpoint intends to use the net proceeds for the manufacturing of CK-301 (cosibelimab), a potential best-in-class anti-PD-L1 antibody, being developed for advanced cutaneous squamous cell carcinoma.

              Lead Product(s): Cosibelimab,Cisplatin,Pemetrexed

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $10.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering July 31, 2023

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              Checkpoint Therapeutics Announces Cosibelimab Longer-Term Results Demonstrating Substantial Increases in Complete Response Rates in Advanced Cutaneous Squamous Cell Carcino...

              Details:

              CK-301 (cosibelimab) is a fully-human mAb of IgG1 subtype that directly binds to PD-L1 and blocks the PDL1 interaction with the PD-1 and B7.1 receptors, which removes the suppressive effects of PD-L1 on anti-tumor CD8+ T-cells to restore the cytotoxic T cell response.

              Lead Product(s): Cosibelimab

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 27, 2023

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              Checkpoint Therapeutics Announces $10 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

              Details:

              Checkpoint intends to use the net proceeds for the manufacturing of CK-301 (cosibelimab), a fully human monoclonal antibody of IgG1 subtype that directly binds to PD-L1 and certain pre-commercial activities in anticipation of potential approval and commercial launch.

              Lead Product(s): Cosibelimab,Pemetrexed,Cisplatin

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $10.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering May 23, 2023

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              Checkpoint Therapeutics Announces $6.1 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

              Details:

              Checkpoint intends to use the net proceeds of this offering for the manufacturing of CK-301 (cosibelimab) and certain pre-commercial activities in anticipation of potential approval and commercial launch.

              Lead Product(s): Cosibelimab,Pemetrexed,Cisplatin

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $6.1 million Upfront Cash: Undisclosed

              Deal Type: Public Offering March 31, 2023

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              Checkpoint Therapeutics Announces FDA Filing Acceptance of Biologics License Application for Cosibelimab in Metastatic or Locally Advanced Cutaneous Squamous Cell Carcinoma

              Details:

              CK-301 (cosibelimab) is a fully-human mAb of IgG1 subtype that directly binds to PD-L1 and blocks the PDL1 interaction with the PD-1 and B7.1 receptors, which removes the suppressive effects of PD-L1 on anti-tumor CD8+ T-cells to restore the cytotoxic T cell response.

              Lead Product(s): Cosibelimab,Pemetrexed,Cisplatin

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 02, 2023

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              Checkpoint Therapeutics Announces $7.5 Million Registered Direct Offering Priced At-The-Market Under Nasdaq Rules

              Details:

              Checkpoint intends to use the net proceeds for the manufacturing of CK-301 (cosibelimab), a potential best-in-class anti-PD-L1 antibody, and certain pre-commercial activities in anticipation of potential approval and commercial launch.

              Lead Product(s): Cosibelimab,Pemetrexed,Cisplatin

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $7.5 million Upfront Cash: Undisclosed

              Deal Type: Public Offering February 21, 2023

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              Checkpoint Therapeutics Announces $7.5 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

              Details:

              CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors.

              Lead Product(s): Cosibelimab,Pemetrexed,Cisplatin

              Therapeutic Area: Oncology Product Name: CK-301

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

              Deal Size: $7.5 million Upfront Cash: Undisclosed

              Deal Type: Public Offering December 15, 2022

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