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    [{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"Amgen Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Collaboration","leadProduct":"Sotorasib","moa":"KRAS G12C","graph1":"Oncology","graph2":"Approved FDF","graph3":"Carmot Therapeutics","amount2":0.23999999999999999,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0.23999999999999999,"dosageForm":"Oral Tablet","sponsorNew":"Carmot Therapeutics \/ Amgen Inc","highestDevelopmentStatusID":"15","companyTruncated":"Carmot Therapeutics \/ Amgen Inc"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2023","type":"Inapplicable","leadProduct":"CT-868","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase II","graph3":"Carmot Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Pre-Filled Injection","sponsorNew":"Carmot Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Carmot Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"CT-996","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase I","graph3":"Carmot Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Carmot Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Carmot Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"Amgen Inc","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2020","type":"Series C Financing","leadProduct":"CT-868","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase I","graph3":"Carmot Therapeutics","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Endocrinology","amount2New":0.050000000000000003,"dosageForm":"Subcutaneous Injection","sponsorNew":"Carmot Therapeutics \/ Amgen Inc","highestDevelopmentStatusID":"6","companyTruncated":"Carmot Therapeutics \/ Amgen Inc"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"Deep Track Capital","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2023","type":"Series E Financing","leadProduct":"CT-388","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase I\/ Phase II","graph3":"Carmot Therapeutics","amount2":0.14999999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Endocrinology","amount2New":0.14999999999999999,"dosageForm":"Subcutaneous Injection","sponsorNew":"Carmot Therapeutics \/ Deep Track Capital","highestDevelopmentStatusID":"7","companyTruncated":"Carmot Therapeutics \/ Deep Track Capital"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"F. 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Morgan","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2023","type":"Public Offering","leadProduct":"CT-388","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase I\/ Phase II","graph3":"Carmot Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Carmot Therapeutics \/ J.P. Morgan","highestDevelopmentStatusID":"7","companyTruncated":"Carmot Therapeutics \/ J.P. Morgan"},{"orgOrder":0,"company":"Carmot Therapeutics","sponsor":"F. Hoffmann-La Roche","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Peptide","year":"2023","type":"Acquisition","leadProduct":"CT-388","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"Phase I","graph3":"Carmot Therapeutics","amount2":3.1000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":3.1000000000000001,"dosageForm":"Subcutaneous Injection","sponsorNew":"Carmot Therapeutics \/ F. Hoffmann-La Roche","highestDevelopmentStatusID":"6","companyTruncated":"Carmot Therapeutics \/ F. Hoffmann-La Roche"}]

    Find Clinical Drug Pipeline Developments & Deals by Carmot Therapeutics

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                            01

                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,100.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Announces Completion of Acquisition by Roche

                            Details : Roche will enhance its portfolio with Carmot’s GLP-1/GIP receptor agonists, including CT-388, CT-996, and CT-868, for metabolic diseases like obesity and diabetes.

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : $2,700.0 million

                            January 29, 2024

                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,100.0 million

                            Deal Type : Acquisition

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                            02

                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Obesity and Diabetes Biotech Carmot Therapeutics Files for IPO

                            Details : The net proceeds will be used to advance the clinical development of CT-388, a novel once-weekly dual GLP-1 and GIP receptor modulator, for the treatment of type-2 diabetes and obesity.

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            November 17, 2023

                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            03

                            Carmot Therapeutics

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                            Lead Product(s) : CT-868

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Commenced Phase 2 Clinical Trial of Novel Dual GLP-1/GIP Receptor Agonist CT-868 for the T...

                            Details : CT-868 is a once-daily subcutaneous injectable, dual GLP-1/GIP receptor agonist being developed as an adjunct to insulin for the treatment of people with type 1 diabetes (T1D) with overweight or obesity.

                            Product Name : CT-868

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            November 15, 2023

                            Lead Product(s) : CT-868

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Carmot Therapeutics

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                            AGGSpend
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                            Carmot Therapeutics

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                            Lead Product(s) : CT-996

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Announces that Preliminary Phase 1 Results Support Once-daily Oral Dosing for its Obesity ...

                            Details : CT-996 is a once-daily oral, small molecule GLP-1 receptor agonist being developed for the treatment of obesity and type 2 diabetes (T2D). it was designed to exhibit signaling bias on the GLP-1 receptor, resulting in activation of cAMP.

                            Product Name : CT-996

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 10, 2023

                            Lead Product(s) : CT-996

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Carmot Therapeutics

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                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $150.0 million

                            Deal Type : Series E Financing

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Raises $150 Million in Series E Equity Financing to Advance its Pipeline of Treatments for...

                            Details : The proceeds will be used to strengthen Carmot's portfolio of clinical and preclinical assets designed to modulate gut hormones that are central to energy homeostasis, including CT-388, a dual GLP-1/GIP receptor modulator for obese adults with and withou...

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            May 25, 2023

                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $150.0 million

                            Deal Type : Series E Financing

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                            06

                            Carmot Therapeutics

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                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase I

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,100.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Enters into Definitive Merger Agreement with Roche

                            Details : Through the acquisition, Roche will build its portfolio by adding Carmot’s pipeline of GLP-1/GIP receptor agonist, including CT-388, CT-996 and CT-868 which are being evaluated for the treatment of metabolic diseases including obesity and diabetes.

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : $2,700.0 million

                            April 12, 2023

                            Lead Product(s) : CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase I

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,100.0 million

                            Deal Type : Acquisition

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                            07

                            Carmot Therapeutics

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                            AGGSpend
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                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : The Column Group

                            Deal Size : $160.0 million

                            Deal Type : Series D Financing

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Closes $160 Million Series D Financing to Advance Clinical Pipeline of Novel Incretin Rece...

                            Details : The funding will support the phase 2 studies for CT-388, a dual modulator of the GLP-1 and GIP incretin receptors, phase 1 studies for CT-996, an oral small molecule GLP-1 receptor agonist, and phase 2 studies for CT-868, a first-inclass fully biased GLP...

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            July 26, 2022

                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : The Column Group

                            Deal Size : $160.0 million

                            Deal Type : Series D Financing

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                            08

                            Carmot Therapeutics

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                            AGGSpend
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                            Carmot Therapeutics

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                            Lead Product(s) : Sotorasib

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Amgen Inc

                            Deal Size : $240.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Carmot to Receive Royalty Payments Upon Sales of Amgen’s FDA Approved First-in-class KRAS G12C Inhibitor, LU...

                            Details : FDA recently approved LUMAKRAS for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, who have received at least one prior systemic therapy.

                            Product Name : Lumakras

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 29, 2021

                            Lead Product(s) : Sotorasib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Amgen Inc

                            Deal Size : $240.0 million

                            Deal Type : Collaboration

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                            09

                            Carmot Therapeutics

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                            AGGSpend
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                            Carmot Therapeutics

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                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Clinical Program for CT-388, a Dual GLP-1 and GIP Receptor Modulator for the Treatment of ...

                            Details : CT-388 is a fully biased dual GLP-1 and GIP receptor modulator with a unique pharmacological profile optimized for improved tolerability at the GLP-1 receptor, anticipated to be dosed once-weekly.

                            Product Name : CT-388

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            June 24, 2021

                            Lead Product(s) : CT-388

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Carmot Therapeutics

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                            Lead Product(s) : CT-868

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : Amgen Inc

                            Deal Size : $47.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Carmot Therapeutics Closes $47 Million Series C Financing to Advance Novel Incretin Receptor Modulators Throug...

                            Details : The funding will support initiation early in 2021 of a 26-week dose ranging phase 2 study for CT-868 and phase 1-2 studies for CT-388 and involve more than 300 patients.

                            Product Name : CT-868

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            September 30, 2020

                            Lead Product(s) : CT-868

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : Amgen Inc

                            Deal Size : $47.0 million

                            Deal Type : Series C Financing

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