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Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Cytokinetics \/ Inapplicable"},{"orgOrder":0,"company":"Ionis Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Inapplicable","leadProduct":"Olezarsen Sodium","moa":"APOC-3 mRNA","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Ionis Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Ionis Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Ionis Pharmaceuticals \/ Inapplicable"}]

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                            Lead Product(s) : Aficamten

                            Therapeutic Area : Cardiology/Vascular Diseases

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                            Cytokinetics Announces Positive Topline Results From MAPLE-HCM

                            Details : CK-3773274 (aficamten) is an investigational selective, small molecule cardiac myosin inhibitor, being developed in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

                            Product Name : CK-3773274

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 13, 2025

                            Lead Product(s) : Aficamten

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            BioCardia

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            BioCardia

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BioCardia Doses First Patient in CardiAMP HF II Phase 3 Heart Trial

                            Details : CardiAMP cell therapy is the first treatment utilizing patient's own cells for the treatment. It is being evaluated for treating ischemic etiology heart failure of reduced ejection fraction.

                            Product Name : CardiAMP

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            May 01, 2025

                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Renibus Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Renibus Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Stannic Protoporfin,Iron Sucrose

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Renibus Completes Enrollment in Phase 3 PROTECT Trial of RBT-1 for Cardiac Surgery

                            Details : RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways, under evaluation to reduce post-operative complications.

                            Product Name : RBT-1

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 24, 2025

                            Lead Product(s) : Stannic Protoporfin,Iron Sucrose

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Bristol Myers Squibb

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Bristol Myers Squibb

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Mavacamten

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bristol Myers Squibb Provides Update on Phase 3 ODYSSEY-HCM Trial

                            Details : Camzyos (mavacamten) is a cardiac myosin inhibitor, being investigated for treatment of adults with class II-III non-obstructive hypertrophic cardiomyopathy.

                            Product Name : Camzyos

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 14, 2025

                            Lead Product(s) : Mavacamten

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            BioCardia

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            BioCardia

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                            Discovery Europe
                            Not Confirmed
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                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Emory University School of Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BioCardia Begins Patient Enrollment for CardiAMP HF II At Emory

                            Details : CardiAMP cell therapy is the first treatment utilizing patient's own cells for the treatment. It is being evaluated for treating ischemic etiology heart failure of reduced ejection fraction.

                            Product Name : CardiAMP

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 11, 2025

                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Emory University School of Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            BioCardia

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            BioCardia

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Biocardia Phase 3 Trial Shows Benefits for Ischemic Heart Failure

                            Details : CardiAMP cell therapy is the first treatment utilizing patient's own cells for the treatment. It is being evaluated for treating ischemic etiology heart failure of reduced ejection fraction.

                            Product Name : CardiAMP

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 31, 2025

                            Lead Product(s) : BCDA-02

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $201.2 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Mineralys Closes Underwriters' Option for Public Stock Offering

                            Details : The net proceeds from the offering will be used to fund the clinical development of MT-4129 (lorundrostat). It is being evaluated for the treatment of Uncontrolled or Resistant Hypertension.

                            Product Name : MT-4129

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 18, 2025

                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $201.2 million

                            Deal Type : Public Offering

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                            08

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $175.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Mineralys Prices $175M Underwritten Public Offering of Common Stock

                            Details : The net proceeds from the offering will be used to fund the clinical development of MT-4129 (lorundrostat). It is being evaluated for the treatment of Uncontrolled or Resistant Hypertension.

                            Product Name : MT-4129

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 11, 2025

                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $175.0 million

                            Deal Type : Public Offering

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                            09

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $287.5 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Mineralys Therapeutics Announces Proposed Public Offering of Common Stock

                            Details : The net proceeds from the offering will be used to fund the clinical development of MT-4129 (lorundrostat). It is being evaluated for the treatment of Uncontrolled or Resistant Hypertension.

                            Product Name : MT-4129

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 10, 2025

                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : BofA Securities

                            Deal Size : $287.5 million

                            Deal Type : Public Offering

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                            10

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed

                            Mineralys Therapeutics

                            U.S.A arrow
                            Discovery Europe
                            Not Confirmed
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                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Mineralys Reports Positive Lorundrostat Data in Uncontrolled Hypertension

                            Details : MLS-101 (lorundrostat) is a proprietary, orally administered, highly selective aldosterone synthase inhibitor being developed for the treatment of uncontrolled hypertension or resistant hypertension.

                            Product Name : MT-4129

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 10, 2025

                            Lead Product(s) : Lorundrostat

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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