Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Cara Therapeutics: Outcome of KOURAGE-1 Study on Oral Difelikefalin in Notalgia
Details : Korsuva (difelikefalin) is a kappa opioid receptor agonists. Its oral formulation is under development for the treatment of moderate-to-severe pruritus in adult patients with notalgia paresthetica.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
December 06, 2024
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CR845 (difelikefalin) is a kappa opioid receptor agonists. Its oral formulation is under clinical development for the treatment of moderate-to-severe pruritus in patients with Atopic Dermatitis.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
December 18, 2023
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Approved FDF
Sponsor : Maruishi Pharmaceutical
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Korsuva (difelikefalin) injection is a kappa opioid receptor agonist indicated for the treatment of moderate-to-severe pruritus in hemodialysis patients.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
September 25, 2023
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Approved FDF
Sponsor : Maruishi Pharmaceutical
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : HealthCare Royalty
Deal Size : $40.0 million
Deal Type : Financing
Details : Cara intends to use the proceeds from the agreement to support the ongoing clinical development of its oral CR845 (difelikefalin) pipeline, including late-stage programs for pruritus associated with atopic dermatitis, advanced chronic kidney disease, and...
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Undisclosed
February 11, 2023
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : HealthCare Royalty
Deal Size : $40.0 million
Deal Type : Financing
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KOMFORT Phase 2 clinical trial evaluating oral Korsuva (difelikefalin) for the treatment of moderate-to-severe pruritus in patients with notalgia paresthetica will be presented during a late-breaking news session.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
August 22, 2022
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Enteris Biopharma Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KORSUVA™ (difelikefalin) injection is the first and only FDA-approved treatment for moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
August 03, 2022
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Enteris Biopharma Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Patients treated with oral Korsuva (difelikefalin) achieved the primary endpoint (-4.0 difelikefalin vs. -2.4 placebo, p=0.001) with significant improvement observed as early as Week 1 and sustained through Week 8.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
June 30, 2022
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Approved FDF
Sponsor : Vifor Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Poster highlights reduction in itch intensity with Kapruvia (difelikefalin) treatment correlated with reductions in inflammatory markers in patients with chronic kidney disease-associated pruritus undergoing hemodialysis.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
April 04, 2022
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Approved FDF
Sponsor : Vifor Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Vifor Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The positive CHMP opinion is based on pivotal clinical data for KALM-1 and KALM-2 trial, for Kapruvia® (difelikefalin), as first therapy in Europe for the treatment of chronic kidney disease associated-pruritus (CKD-aP) in hemodialysis patients.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
February 25, 2022
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Vifor Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Enteris Biopharma Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The Phase 2 multicenter, randomized, double-blind, placebo-controlled 8-week study is designed to evaluate the efficacy and safety of Oral KORSUVA™ for moderate-to-severe pruritus in approximately 120 subjects with NP.
Product Name : Korsuva
Product Type : Peptide
Upfront Cash : Inapplicable
November 01, 2021
Lead Product(s) : Difelikefalin Acetate
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Enteris Biopharma Inc
Deal Size : Inapplicable
Deal Type : Inapplicable