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    [{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-protein Conjugate","year":"2025","type":"Inapplicable","leadProduct":"Ficerafusp Alfa","moa":"EGFR","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Red Tree Venture Capital","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2023","type":"Series B Financing","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicara Therapeutics","amount2":0.11,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.11,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Red Tree Venture Capital","highestDevelopmentStatusID":"7","companyTruncated":"Bicara Therapeutics \/ Red Tree Venture Capital"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Public Offering","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0.32000000000000001,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0.35999999999999999,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Morgan Stanley","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Morgan Stanley"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Biocon","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2021","type":"Financing","leadProduct":"Ficerafusp Alpha","moa":"EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicara Therapeutics","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.040000000000000001,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Biocon","highestDevelopmentStatusID":"7","companyTruncated":"Bicara Therapeutics \/ Biocon"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Braidwell LP","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2023","type":"Series C Financing","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0.17000000000000001,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0.17000000000000001,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Braidwell LP","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Braidwell LP"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Public Offering","leadProduct":"Ficerafusp Alpha","moa":"||EGFR\/TGF-beta","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicara Therapeutics","amount2":0.35999999999999999,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0.35999999999999999,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Morgan Stanley","highestDevelopmentStatusID":"9","companyTruncated":"Bicara Therapeutics \/ Morgan Stanley"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2020","type":"Inapplicable","leadProduct":"BCA101","moa":"Epidermal growth factor receptor (EGFR)","graph1":"Oncology","graph2":"Phase I","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bicara Therapeutics \/ Merck & Co","highestDevelopmentStatusID":"6","companyTruncated":"Bicara Therapeutics \/ Merck & Co"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"BCA356","moa":"IL-12 receptor","graph1":"Oncology","graph2":"Preclinical","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bicara Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Bicara Therapeutics \/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals by Bicara Therapeutics

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                            01

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bicara Begins Ficerafusp Alfa Phase 2/3 Trial in 1L R/M Head & Neck Cancer

                            Details : BCA101 (ficerafusp alfa) is a first-in-class bifunctional antibody which is being evaluated in combination with pembrolizumab in first line recurrent/metastatic head and neck squamous cell carcinoma.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            February 11, 2025

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Bicara Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Ficerafusp Alfa

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line P...

                            Details : Ficerafusp Alfa is a Antibody-protein Conjugate drug candidate, which is currently being evaluated in phase II/ phase III clinical studies for the treatment of Squamous Cell Carcinoma of Head and Neck.

                            Product Name : Undisclosed

                            Product Type : Antibody-protein Conjugate

                            Upfront Cash : Inapplicable

                            January 23, 2025

                            Lead Product(s) : Ficerafusp Alfa

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Morgan Stanley

                            Deal Size : $362.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Closes $362M IPO with Full Exercise of Underwriters' Option

                            Details : The net proceeds from the financing will be used to support the development of BCA101 (ficerafusp alfa) a first-in-class, bifunctional EGFR/TGF-β antibody for head and neck squamous cell carcinoma.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            September 16, 2024

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Morgan Stanley

                            Deal Size : $362.0 million

                            Deal Type : Public Offering

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                            04

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Morgan Stanley

                            Deal Size : $315.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Announces Pricing of Upsized Initial Public Offering

                            Details : The net proceeds from the financing will be used to support the development of BCA101 (ficerafusp alfa) a first-in-class, bifunctional EGFR/TGF-β antibody for head and neck squamous cell carcinoma.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            September 12, 2024

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Morgan Stanley

                            Deal Size : $315.0 million

                            Deal Type : Public Offering

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                            05

                            Bicara Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bicara Reports Updated Data for Ficerafusp Alfa in HPV-negative Head and Neck Cancer

                            Details : BCA101 (ficerafusp alfa), a first-in-class bifunctional EGFR/TGF-β inhibitor, investigated for frontline HPV-negative, R/M HNSCC, advanced squamous NSCLC and cutaneous squamous cell carcinoma.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            June 27, 2024

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Braidwell LP

                            Deal Size : $165.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Announces Oversubscribed $165 Million Series C Financing

                            Details : The proceeds will be used to support the advancement of Bicara’s lead product, BCA101, a first-in-class bifunctional EGFR/TGF-β inhibitor, for multiple cancer types including frontline HPV-negative, R/M HNSCC, advanced squamous NSCLC and cutaneous squ...

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            December 12, 2023

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Braidwell LP

                            Deal Size : $165.0 million

                            Deal Type : Series C Financing

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                            07

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Red Tree Venture Capital

                            Deal Size : $108.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Announces Oversubscribed $108 Million Series B Financing to Advance Clinical-Stage Pipelin...

                            Details : The Financing will support future studies of lead program BCA101, a first-in-class EGFR / TGF-β-trap bifunctional antibody, currently in Phase 1/1b clinical development in head and neck cancer, and pipeline growth.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            March 06, 2023

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Red Tree Venture Capital

                            Deal Size : $108.0 million

                            Deal Type : Series B Financing

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                            08

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BCA356

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Presents Preclinical Data for Precision Immunocytokine, BCA356, at Society for Immunothera...

                            Details : BCA356 specifically targets CAIX-expressing tumor cells, and similar to wild type IL-12 cytokine, has the potential to reduce tumor proliferation with optimal activation of additional pro-inflammatory cytokines.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            November 07, 2022

                            Lead Product(s) : BCA356

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Presents Data from Dose Escalation Portion of Ongoing Phase 1/1b Trial of Lead Bifunctiona...

                            Details : BCA101 is a first-in-class antibody with a unique mechanism of anti-tumor activity that has demonstrated encouraging safety, pharmacokinetic, pharmacodynamic and efficacy profiles.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            June 03, 2022

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Bicara Therapeutics

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                            AIChE Annual Meeting
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                            Bicara Therapeutics

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                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bicara Therapeutics Initiates Dose Expansion Arm of Phase 1/1b Clinical Study of BCA101 in Disease-Specific Co...

                            Details : Study will evaluate BCA101, EGFR / TGF-β-trap bifunctional antibody in patients with head and neck squamous cell carcinoma, squamous cell carcinoma of the anal canal and cutaneous squamous cell carcinoma.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            February 22, 2022

                            Lead Product(s) : Ficerafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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