[{"orgOrder":0,"company":"Burke Neurological Institute","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Vitamin B1","moa":"Bacterial Pyruvate decarboxylase (Bact aceE)","graph1":"Neurology","graph2":"Phase II","graph3":"Burke Neurological Institute","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Burke Neurological Institute \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Burke Neurological Institute \/ Undisclosed"},{"orgOrder":0,"company":"Hoskinson Health and Wellness Clinic","sponsor":"Buck Institute for Research on Aging | University of Wyoming","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Vitamin B1","moa":"Bacterial Pyruvate decarboxylase (Bact aceE)","graph1":"Endocrinology","graph2":"Phase I","graph3":"Hoskinson Health and Wellness Clinic","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Hoskinson Health and Wellness Clinic \/ Buck Institute for Research on Aging | University of Wyoming","highestDevelopmentStatusID":"6","companyTruncated":"Hoskinson Health and Wellness Clinic \/ Buck Institute for Research on Aging | University of Wyoming"},{"orgOrder":0,"company":"PROCTER AND GAMBLE","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Vitamin B1","moa":"Bacterial Pyruvate decarboxylase (Bact aceE)","graph1":"Neurology","graph2":"Phase III","graph3":"PROCTER AND GAMBLE","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Liquid","sponsorNew":"PROCTER AND GAMBLE \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"PROCTER AND GAMBLE \/ Undisclosed"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Burke Neurological Institute

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                          Burke Neurological Institute

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                          Details : Benfotiamine is a synthetic version of vitamin B1 (thiamine), which is being evaluated as a treatment for mild cognitive impairment and early Alzheimer's disease.

                          Product Name : Benfotiamine

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 23, 2024

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Hoskinson Health and Wellness Clinic

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                          Not Confirmed

                          Hoskinson Health and Wellness Clinic

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                          PackExpo
                          Not Confirmed

                          Details : Vitamin B1 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Insulin Resistance.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 05, 2024

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : Buck Institute for Research on Aging | University of Wyoming

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Vitamin B1 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Peripheral Nervous System Diseases.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 16, 2022

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Spectrum Health - Lakeland

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                          Not Confirmed

                          Spectrum Health - Lakeland

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                          Not Confirmed

                          Details : Thiamine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in clinical studies for the treatment of Shock, Septic.

                          Product Name : Undisclosed

                          Product Type : Vitamins/Minerals/Inorganic Salts

                          Upfront Cash : Inapplicable

                          May 30, 2018

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Thiamine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Heart Failure.

                          Product Name : Undisclosed

                          Product Type : Vitamins/Minerals/Inorganic Salts

                          Upfront Cash : Inapplicable

                          July 24, 2017

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : McMaster/St. Peter's Hospital Chair of Aging

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Thiamine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Radiculopathy.

                          Product Name : Undisclosed

                          Product Type : Vitamins/Minerals/Inorganic Salts

                          Upfront Cash : Inapplicable

                          July 27, 2015

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Bausch Health

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Thiamine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Beriberi.

                          Product Name : Undisclosed

                          Product Type : Vitamins/Minerals/Inorganic Salts

                          Upfront Cash : Inapplicable

                          May 29, 2013

                          Lead Product(s) : Vitamin B1

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Eastern Mennonite Missions | Arup Laboratories

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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