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Find Clinical Drug Pipeline Developments & Deals for Acalabrutinib
The two companies will jointly conduct Phase III of the Bcl-2 inhibitor, APG-2575 (lisaftoclax), in combination with AstraZeneca's BTK inhibitor, Calquence (acalabrutinib), in treatment-naive patients with first-line chronic lymphocytic leukemia/small lymphocytic lymphoma.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). It has been approved in China for the treatment of chronic lymphocytic leukaemia or small lymphocytic lymphoma who have received at least one prior therapy.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). It has been granted first regulatory approval in china for adults with previously treated mantle cell lymphoma.
Calquence (acalabrutinib) is a next-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK). Its tablet formulation has been approved in the EU for patients with chronic lymphocytic leukaemia.
Calquence (acalabrutinib), a next-generation, selective inhibitor of BTK, binds covalently to BTK, thereby inhibiting its activity. In B cells, BTK signalling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis and adhesion.
In the trials, results showed the CALQUENCE capsule and tablet formulations are bioequivalent, indicating the same efficacy and safety profile can be expected with the same dosing strength and schedule.
Updated data from ELEVATE-TN Phase III trial at five years, will highlight longer-term safety, PFS efficacy results and OS rates for Calquence (Acalabrutinib) in combination with obinutuzumab and alone compared to obinutuzumab plus chlorambucil in adults with CLL.
Updated results from ELEVATE-TN trial showed CALQUENCE (acalabrutinib) maintained significant PFS versus chlorambucil plus obinutuzumab and safety and tolerability profile consistent with known profile for CALQUENCE at median follow up of five years in combination.
At a median follow-up of 58.2 months, Calquence (Acalabrutinib) plus obinutuzumab reduced risk of disease progression or death by 89% and as a monotherapy by 79% (based on a HR of 0.21, 95% CI 0.15-0.30), compared with chlorambucil plus obinutuzumab.
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