Global sales information of Mupirocin with Finished Drug Prices obtained from US Medicaid's National Average Drug Acquisition Cost

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Chemistry

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Also known as: 12650-69-0, Pseudomonic acid, Bactroban, Mupirocine, Centany, Pseudomonic acid a
Molecular Formula
C26H44O9
Molecular Weight
500.6  g/mol
InChI Key
MINDHVHHQZYEEK-HBBNESRFSA-N
FDA UNII
D0GX863OA5

Mupirocin
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Mupirocin is a RNA Synthetase Inhibitor Antibacterial. The mechanism of action of mupirocin is as a RNA Synthetase Inhibitor.
1 2D Structure

Mupirocin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
2.1.2 InChI
InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
2.1.3 InChI Key
MINDHVHHQZYEEK-HBBNESRFSA-N
2.1.4 Canonical SMILES
CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O
2.1.5 Isomeric SMILES
C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
2.2 Other Identifiers
2.2.1 UNII
D0GX863OA5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 14c-labeled Mupirocin

2. Bactroban

3. Brl 4910a

4. Brl-4910a

5. Brl4910a

6. Mupirocin Calcium

7. Mupirocin, 14c Labeled

8. Mupirocin, 14c-labeled

9. Mupirocin, Calcium Salt (2:1)

10. Mupirocin, Calcium Salt (2:1), Dihydrate

11. Mupirocin, Lithium Salt

12. Mupirocin, Sodium Salt

13. Pseudomonic Acid

14. Pseudomonic Acid A

2.3.2 Depositor-Supplied Synonyms

1. 12650-69-0

2. Pseudomonic Acid

3. Bactroban

4. Mupirocine

5. Centany

6. Pseudomonic Acid A

7. Bactoderm

8. Mupirocina

9. Mupirocinum

10. Turixin

11. Brl 4910a

12. Brl-4910a

13. Trans-pseudomonic Acid

14. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic Acid

15. Bactroban (tn)

16. Chembl719

17. Nsc-759182

18. Chebi:7025

19. D0gx863oa5

20. Mrc

21. Ncgc00164554-03

22. Plasimine

23. 80558-54-9

24. L-talo-non-2-enonic Acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2s,3s)-3-[(1s,2s)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl Ester, (2e)-

25. Mupirocine [french]

26. Mupirocinum [latin]

27. Mupirocina [spanish]

28. Bactroban Ointment

29. 9-(((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoic Acid

30. Centany (tn)

31. Mupirocin Neo-sensitabs

32. Mupirocin (usp/inn)

33. Sr-05000001947

34. Unii-d0gx863oa5

35. 1jzs

36. Mupirocin [usan:usp:inn:ban]

37. Mupirocin,(s)

38. 9-((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

39. Mfcd01711620

40. Cpd000471888

41. Mupirocin [inn]

42. Mupirocin [mi]

43. Mupirocin [usan]

44. Mupirocin [vandf]

45. Mupirocin [mart.]

46. Mupirocin [usp-rs]

47. Mupirocin [who-dd]

48. Schembl3291

49. Dsstox_cid_26438

50. Dsstox_rid_81614

51. Dsstox_gsid_46438

52. 8-carboxyoctyl (e)-4-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxytetrahydro-2h-pyran-2-yl)-3-methylcrotonat

53. Mls001074711

54. Bidd:gt0320

55. Mupirocin, Pseudomonic Acid A

56. Mupirocin [green Book]

57. Cid_446596

58. Schembl1027618

59. Mupirocin [orange Book]

60. Dtxsid0046438

61. Mupirocin [ep Monograph]

62. Mupirocin [usp Impurity]

63. Chebi:94519

64. Gtpl10916

65. Mupirocin [usp Monograph]

66. Hms2234e20

67. Hms3259l05

68. Hms3712k03

69. Pharmakon1600-01505706

70. Hy-b0958

71. Zinc4102194

72. Tox21_112183

73. Bdbm50290686

74. Nsc759182

75. Nsc815348

76. Akos015994756

77. Mupirocin, >=92% (hplc), Powder

78. Ccg-213522

79. Db00410

80. Fd12069

81. Ks-5137

82. Nc00620

83. Nsc 759182

84. Nsc-815348

85. Ncgc00164554-05

86. Ncgc00164554-06

87. (e)-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-beta-methyl-2h-pyran-2-crotonic Acid, Ester With 9-hydroxynonanoic Acid

88. As-11580

89. Smr000471888

90. Sbi-0206892.p001

91. Cas-12650-69-0

92. M2955

93. S4297

94. D01076

95. M-8680

96. Ab01563109_01

97. Mupirocin, Antibiotic For Culture Media Use Only

98. Q413578

99. Sr-05000001947-1

100. Sr-05000001947-2

101. Brd-k15262564-001-06-9

102. Mupirocin, United States Pharmacopeia (usp) Reference Standard

103. (2e)-5,9-anhydro-2,3,4,8-tetradeoxy-8-(((2s,3s)-3-((1s,2s)-2-hydroxy-1-methylpropyl)oxiranyl)methyl)-3-methyl-l-talo-non-2-enonic Acid, 8-carboxyoctyl Ester

104. (e)-(2s,3r,4r,5s)-5-((2s,3s,4s,5s)-2,3-epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-.beta.-methyl-2h-pyran-2-crotonic Acid, Ester With 9-hydroxynonanoic Acid

105. 9-((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)-tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

106. 9-((e)-4-{(2s,3r,4r,5s)-3,4-dihydroxy-5-[(2s,3s)-3-((1s,2s)-2-hydroxy-1-methyl-propyl)-oxiranylmethyl]-tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)-nonanoic Acid

107. 9-({(2e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-({(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)tetrahydro-2h-pyran-2-yl]-3-methylbut-2-enoyl}oxy)nonanoic Acid

108. 9-(4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)-tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyloxy)nonanoic Acid

109. 9-(4-{3,4-dihydroxy-5-[3-(2-hydroxy-1-methyl-propyl)-oxiranylmethyl]-tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)-nonanoic Acid (mupirocin)

110. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3- [(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] Oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic Acid

111. 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[[(2s,3s)-3-[(1s,2s)-2-hydroxy-1-methyl-propyl]oxiran-2-yl]methyl]tetrahydropyran-2-yl]-3-methyl-but-2-enoyl]oxynonanoic Acid

112. 9-{[(2e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-{[(2s,3s)-3-[(2s,3s)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic Acid

113. Nonanoic Acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2h-pyran-2-yl)-2-butenyl)oxy)-, (2s-(2.alpha.(e),3.beta.,4.beta.,5.alpha.(2r*,3r*(1r*,2r*))))-

114. Nonanoic Acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2h-pyran-2-yl)-2-butenyl)oxy)-, (2s-(2alpha(e),3beta,4beta,5alpha(2r*,3r*(1r*,2r*))))-

115. Rel-9-(((e)-4-((2s,3r,4r,5s)-3,4-dihydroxy-5-(((2s,3s)-3-((2s,3s)-3-hydroxybutan-2-yl)oxiran-2-yl)methyl)tetrahydro-2h-pyran-2-yl)-3-methylbut-2-enoyl)oxy)nonanoic Acid

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 500.6 g/mol
Molecular Formula C26H44O9
XLogP33
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count17
Exact Mass500.29853298 g/mol
Monoisotopic Mass500.29853298 g/mol
Topological Polar Surface Area146 Ų
Heavy Atom Count35
Formal Charge0
Complexity694
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameBactroban
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin calcium; Mupirocin
Dosage FormOintment; Cream
RouteNasal; Topical
Strength2%; eq 2% base
Market StatusPrescription
CompanyGlaxosmithkline

2 of 6  
Drug NameCentany
PubMed HealthMupirocin (On the skin)
Drug ClassesAntibacterial
Drug LabelEach gram of Centany (mupirocin ointment),2% contains 20 mg mupirocin in a soft white ointment base consisting of castor oil, oleyl alcohol, hard fat (Softisan 378) and propylene glycol monostearate. Mupirocin is a naturally occurring antibiotic. T...
Active IngredientMupirocin
Dosage FormOintment
RouteTopical
Strength2%
Market StatusPrescription
CompanyPerrigo New York

3 of 6  
Drug NameMupirocin
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin; Mupirocin calcium
Dosage FormOintment; Cream
RouteTopical
Strengtheq 2% base; 2%
Market StatusPrescription
CompanyGlenmark Pharms; Teva; Taro; Glenmark Generics; Fougera Pharms; Perrigo New York

4 of 6  
Drug NameBactroban
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin calcium; Mupirocin
Dosage FormOintment; Cream
RouteNasal; Topical
Strength2%; eq 2% base
Market StatusPrescription
CompanyGlaxosmithkline

5 of 6  
Drug NameCentany
PubMed HealthMupirocin (On the skin)
Drug ClassesAntibacterial
Drug LabelEach gram of Centany (mupirocin ointment),2% contains 20 mg mupirocin in a soft white ointment base consisting of castor oil, oleyl alcohol, hard fat (Softisan 378) and propylene glycol monostearate. Mupirocin is a naturally occurring antibiotic. T...
Active IngredientMupirocin
Dosage FormOintment
RouteTopical
Strength2%
Market StatusPrescription
CompanyPerrigo New York

6 of 6  
Drug NameMupirocin
PubMed HealthMupirocin
Drug ClassesAntibacterial, Antibiotic
Drug LabelBACTROBAN CREAM (mupirocin calcium cream, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (E,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy--methyl-...
Active IngredientMupirocin; Mupirocin calcium
Dosage FormOintment; Cream
RouteTopical
Strengtheq 2% base; 2%
Market StatusPrescription
CompanyGlenmark Pharms; Teva; Taro; Glenmark Generics; Fougera Pharms; Perrigo New York

4.2 Drug Indication

Indicated for the treatment of impetigo and secondary skin infections, leading to traumatic skin lesions, due to _Staphylococcus aureus_ and _Streptococcus pyogenes_.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Mupirocin is reported to be active against susceptible aerobic gram-positive cocci, such as _Staphylococcus aureus_, _Staphylococcus epidermidis_, and other beta-hemolytic streptococci_Streptococcus pyogenes_. It mediates its antibacterial activity by inhibiting the bacterial protein synthesis and formation of bacterial proteins essential for survival. The minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC). In one clinical study investigating the therapeutic effectiveness of topical mupirocin in impetigo, the therapeutic response rate was about 94 to 98% after one week following the end of therapy. In clinical studies of patients with primary and secondary skin infections, both elimination of the bacterial pathogen and clinical cure or improvement hav been demonstrated in over 90% of patients receiving topical mupirocin. Mupirocin resistance as high as 81% has been reported previously. Resistance to mupirocin, which occurs more frequently in methicillin-resistant than methicillin-susceptible staphylococci, may occur with the production of a modified isoleucyl-tRNA synthetase, or the acquisition of, by genetic transfer, a plasmid mediating a new isoleucyl-tRNA synthetase.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
MUPIROCIN
5.3.2 FDA UNII
D0GX863OA5
5.3.3 Pharmacological Classes
RNA Synthetase Inhibitors [MoA]; RNA Synthetase Inhibitor Antibacterial [EPC]
5.4 ATC Code

D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AX - Other antibiotics for topical use

D06AX09 - Mupirocin


R - Respiratory system

R01 - Nasal preparations

R01A - Decongestants and other nasal preparations for topical use

R01AX - Other nasal preparations

R01AX06 - Mupirocin


5.5 Absorption, Distribution and Excretion

Absorption

Systemic or percutaneous absorption of mupirocin following dermal application is expected to be minimal in adults and children. Occlusive dressings do not significantly enhance drug absorption, but damaged skin may allow enhanced penetration of the drug across the skin barrier.


Route of Elimination

Any mupirocin reaching the systemic circulation is rapidly metabolized to form the inactive monic acid, which is eliminated by renal excretion. Following the application of Centany (mupirocin ointment),2% to a 400 cm2 area on the back of 23 healthy volunteers once daily for 7 days, the mean (range) cumulative urinary excretion of monic acid over 24 hrs following the last administration was 1.25% (0.2% to 3.0%) of the administered dose of mupirocin.


Volume of Distribution

No information available.


Clearance

No information available.


5.6 Metabolism/Metabolites

Following intravenous or oral administration, mupirocin undergoes rapid hepatic metabolism to form the principal metabolite monic acid, which has no antibacterial activity.


5.7 Biological Half-Life

In healthy male volunteers, the elimination half-life of mupirocin was about 20 to 40 minutes following intravenous administration. The elimination half-life of monic acid was about 30 to 80 minutes.


5.8 Mechanism of Action

Mupirocin specifically and reversibly binds to bacterial isoleucyl transfer-RNA (tRNA) synthetase, which is an enzyme that promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Inhibition of this enzyme subsequently leads to the inhibition of the bacterial protein and RNA synthesis. Mupirocin is bacteriostatic at lower concentrations but it exerts bactericidal effects with prolonged exposure, killing 90-99% of susceptible bacteria over a 24 hour period.


API Reference Price

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04-Jan-2021
26-Aug-2024
KGS
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