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ACTIVE PHARMA INGREDIENTS

31 API Suppliers, 19 USDMF, 14 CEP/COS, 6 EU WC, 5 NDC API, 17 Listed Suppliers, $ API Reference Price

31 API Suppliers
19 USDMF
14 CEP/COS
6 EU WC
5 NDC API
17 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

5 Intermediates Suppliers

5 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

177 FDF Dossiers, 118 FDA Orange Book, 5 Europe, 19 Canada, 6 Australia, 8 South Africa, 21 Listed Dossiers

177 FDF Dossiers
118 FDA Orange Book
5 Europe
19 Canada
6 Australia
8 South Africa
21 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 10MG, TABLET;ORAL - 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - 2.5MG, TABLET;ORAL - 2MG, TABLET;ORAL - 3MG, TABLET;ORAL - 4MG, TABLET;ORAL - 5MG, TABLET;ORAL - 6MG, TABLET;ORAL - 7.5MG

drugProductComposition
TABLET;ORAL - 10MG
TABLET;ORAL - 1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 2.5MG
TABLET;ORAL - 2MG
TABLET;ORAL - 3MG
TABLET;ORAL - 4MG
TABLET;ORAL - 5MG
TABLET;ORAL - 6MG
TABLET;ORAL - 7.5MG

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 21 SPI Pharma, 2 DKSH, 1 Jai Radhe Sales, 1 Boai NKY Pharmaceuticals Ltd, 12 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 2 Actylis, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 10 Corel Pharma Chem, 6 DFE Pharma, 7 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 37 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 14 Microlex e.U, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 6 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 16 Roquette, 7 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 10 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

83 Fillers, Diluents & Binders, 41 Direct Compression, 40 Coating Systems & Additives, 23 Granulation, 23 Controlled & Modified Release, 21 Disintegrants & Superdisintegrants, 20 Co-Processed Excipients, 17 Thickeners and Stabilizers, 16 Chewable & Orodispersible Aids, 15 Taste Masking, 11 Lubricants & Glidants, 9 Parenteral, 8 Solubilizers, 6 Film Formers & Plasticizers, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Emulsifying Agents, 3 Coloring Agents, 3 Rheology Modifiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 11 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 21 Finished Drug Prices, 2 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
21 Finished Drug Prices
2 Annual Reports

MARKET PLACE

11 APIs, 12 FDF Dossiers

marketPlace
11 APIs
12 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 Others

otherSolutions
2 EDQM
1 Others

ANALYTICAL

1 BioAnalytical Methods, 2 Analytical Methods

otherMethods
1 BioAnalytical Methods
2 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 651

MARKET PLACE

API

FDF

5INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

177

FDF Dossiers

118

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

81,438,539

Annual Reports (USD Million)

110

Finished Drug Prices

215 RELATED EXCIPIENT COMPANIES

357EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 129-06-6, Sodium warfarin, Jantoven, Aldocumar, Athrombin, Marevan

Molecular Formula

C₁₉H₁₅NaO₄

Molecular Weight

330.3 g/mol

InChI Key

KYITYFHKDODNCQ-UHFFFAOYSA-M

FDA UNII

6153CWM0CL

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

1 2D Structure

Warfarin Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate

2.1.2 InChI

InChI=1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1

2.1.3 InChI Key

KYITYFHKDODNCQ-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

6153CWM0CL

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2h-1-benzopyran-2-one

2. Aldocumar

3. Apo-warfarin

4. Coumadin

5. Coumadine

6. Gen-warfarin

7. Marevan

8. Potassium, Warfarin

9. Sodium, Warfarin

10. Tedicumar

11. Warfant

12. Warfarin

13. Warfarin Potassium

2.3.2 Depositor-Supplied Synonyms

1. 129-06-6

2. Sodium Warfarin

3. Jantoven

4. Aldocumar

5. Athrombin

6. Marevan

7. Zoocoumarin Sodium Salt

8. Warfarin Sodium Salt

9. Apo-warfarin

10. Warfarin (sodium)

11. Sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-2h-chromen-4-olate

12. Warfarin Sodium [usp]

13. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin Sodium Salt

14. 6153cwm0cl

15. Warfarin Sodium Clathrate

16. 2h-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, Sodium Salt

17. 67430-45-9

18. Coumadine

19. Dicusat

20. Marevam

21. Orfarin

22. Tintorane

23. Varfine

24. Warcoumin

25. Warfarin Sodium (usp)

26. Warfilone

27. Simarc

28. Coumadin Sodium

29. Sodium Coumadin

30. Uniwarfin

31. Ratsul Soluble

32. Coumadan Sodico

33. Coumafene Sodium

34. Warfarinsodium

35. Sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate

36. Warfarin, Sodium Salt

37. Caswell No. 903a

38. Warfarin-sodium

39. (+-)-warfarin Sodium

40. Warfarin, Sodium Deriv.

41. Einecs 204-929-4

42. 3-(3-oxo-1-phenylbutyl)-4-sodiooxy-2h-1-benzopyran-2-one

43. Epa Pesticide Chemical Code 086003

44. Unii-6153cwm0cl

45. Warfarinum Natricum

46. Coumadin (tn)

47. Jantoven (tn)

48. Einecs 226-909-4

49. Sodium, ((3-(alpha-acetonylbenzyl)-2-oxo-2h-1-benzopyran-4-yl)oxy)-

50. Warfarin Sodium Clatharate

51. Schembl7826

52. Dsstox_cid_15010

53. Dsstox_rid_79236

54. Dsstox_gsid_35010

55. Mls001074341

56. Warfarin Sodium [vandf]

57. Chembl1200879

58. Dtxsid7035010

59. Warfarin Sodium [mart.]

60. Hy-b0687a

61. Warfarin Sodium [who-dd]

62. Warfarin Sodium [who-ip]

63. Warfarin Sodium Salt [mi]

64. Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-, Sodium Salt

65. Hms2233p10

66. Hms3259g13

67. Hms3369m10

68. Bcp20702

69. Tox21_301545

70. Bdbm50248297

71. Warfarin Sodium [orange Book]

72. Akos015951251

73. Akos015955387

74. Warfarin Sodium [ep Monograph]

75. Ac-8078

76. Cs-w019743

77. Nc00490

78. Warfarin Sodium [usp Monograph]

79. Ncgc00255556-01

80. Ac-19972

81. Cas-129-06-6

82. Smr000058849

83. Warfarinum Natricum [who-ip Latin]

84. W0005

85. Warfarin Sodium (contains Isopropyl Alcohol)

86. D00564

87. O12075

88. A805899

89. J-005647

90. Sodium Warfarin;warf42 Sodium; Athrombine-k Sodium

91. Q27263296

92. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin Sodiuim Salt

93. 4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin Sodium Salt

94. Sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-1-benzopyran-4-olate

95. 3-(.alpha.-acetonylbenzyl)-4-hydroxycoumarin Sodium Salt

96. Sodium 2-oxidanylidene-3-(3-oxidanylidene-1-phenyl-butyl)chromen-4-olate

97. 2h-1-benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, Sodium Salt (1:1)

2.4 Create Date

2007-07-11

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₅NaO₄
Molecular Weight	330.3 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	330.08680324 g/mol
Monoisotopic Mass	330.08680324 g/mol
Topological Polar Surface Area	66.4 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	508
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Jantoven
PubMed Health	Warfarin
Drug Classes	Anticoagulant
Drug Label	JantovenTablets (crystalline warfarin sodium) is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an isopropan...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Usl Pharma

2 of 4
Drug Name	Warfarin sodium
Drug Label	Warfarin sodium tablet (crystalline warfarin sodium) is an anticoagulant, which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an i...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Amneal Pharms; Taro; Invagen Pharms; Ipca Labs; Zydus Pharms Usa; Pliva; Mylan; Barr

3 of 4
Drug Name	Jantoven
PubMed Health	Warfarin
Drug Classes	Anticoagulant
Drug Label	JantovenTablets (crystalline warfarin sodium) is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an isopropan...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Usl Pharma

4 of 4
Drug Name	Warfarin sodium
Drug Label	Warfarin sodium tablet (crystalline warfarin sodium) is an anticoagulant, which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(and is a racemic mixture of the R- and S-enantiomers. Crystalline warfarin sodium is an i...
Active Ingredient	Warfarin sodium
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 7.5mg; 1mg; 5mg; 4mg; 6mg; 2mg; 10mg; 3mg
Market Status	Prescription
Company	Amneal Pharms; Taro; Invagen Pharms; Ipca Labs; Zydus Pharms Usa; Pliva; Mylan; Barr

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anticoagulants

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)

Rodenticides

Substances used to destroy or inhibit the action of rats, mice, or other rodents. (See all compounds classified as Rodenticides.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Vitamin K Inhibitors [MoA]; Vitamin K Antagonist [EPC]

API SUPPLIERS

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USDMF

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CEP/COS

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - 10MG